Parallel Processing of Microwave-Assisted Organic Transformations

Abstract

Microwave-assisted organic synthesis is an enabling technology that has been exploited for a variety of applications including medicinal chemistry/drug discovery projects where speed is often a critical factor. In this review, applications of microwave-assisted organic synthesis employing a parallel processing regime are summarized. Examples include parallel synthesis in domestic microwave ovens, the use of specialized multivessel rotors and microtiter plates in dedicated multimode microwave reactors, and applications of SPOT synthesis on cellulose matrices.

Comprehensive Survey of Chemical Libraries for Drug Discovery and Chemical Biology: 2007

“…Related publications and reviews appeared in 2007 on fluorous chemistry and separations, − multicomponent condensations, − fragment-based lead discovery, − high-throughput heterocyclic synthesis, , applications of click chemistry, dynamic combinatorial chemistry, DNA-encoded chemical libraries, chemical genomics, − high-throughput microwave synthesis, − library design, − combinatorial solid-phase natural product chemistry, heterocyclic synthesis with 1,5-difluoro-2,4-dinitrobenzene, synthesis of flavonoid, medium-sized lactam, and diketopiperazine scaffolds, DNA-binding library, PNA-encoded libraries, polyamine analog libraries, aziridines in parallel synthesis, colorimetric tests for the detection of hydroxyl groups and aromatic amines, catch-and-release techniques, continuous-flow microchemical synthesis, one-bead-one-reactor synthesis, discovery of chemical reactions through multidimensional screening, phase-switch synthesis with boronic acids, image-based screening, and label-free detection of solid-phase-bound compounds via Raman scattering microspectroscopy …”

“…Methodology selections include a new method for converting alcohols to primary amines, 380 mild hydrolysis of resin-bound ester with Me 3 SnOH, 252 new application of resin-bound selenyl bromide for heterocyclic synthesis, 147,148 post functionalization of multicomponent reactions (MCRs) yielding polycyclic ring systems, 317,368,369 an MCR leading to highly substituted γ-lactams, 422 and the use of fluorous technology in the synthesis of DOS and natural-product-like libraries. 78,212,243,451 Related publications and reviews appeared in 2007 on fluorous chemistry and separations, [482][483][484][485] multicomponent condensations, [486][487][488][489] fragment-based lead discovery, [490][491][492][493][494][495][496] high-throughput heterocyclic synthesis, 497,498 applications of click chemistry, 499 dynamic combinatorial chemistry, 500 DNAencoded chemical libraries, 501 chemical genomics, [502][503][504][505][506][507] highthroughput microwave synthesis, [508][509][510][511]…”