Parallel Tubular Structures in Lymphocytes

Halie,; Splettromascano, M; Molenaar, [No Value]; Nieweg, H. O.

doi:10.1159/000208046

Cited by 14 publications

(1 citation statement)

References 8 publications

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“…PTA are ultrastructurally distinctive or ganelles present in a small subgroup of normal lymphocytes [13][14][15][16][17] . On the other hand, PTA were found in neoplastic lymphocytes, in T-CLL [15] and Ty-CLL [2][3][4][5].…”

Section: Discussionmentioning

confidence: 99%

Ultrastructure of Normal Human T Cell Subpopulations

Kanayama¹,

Hiraoka²,

Konishi³

et al. 1983

Acta Haematol

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Ultrastructures of normal T-cell subpopulations, Tγ and Tμ cells, were studied. Tγ cells were isolated and identified by repeating the rosetting method; firstly, by E rosette formation with neuraminidase-treated sheep red blood cells (SRBC), and next by EAy-rosette formation with ox red blood cells coated with IgG antibody (EAox). Before EAox rosetting, SRBC on isolated T cells were lysed by autologous plasma instead of ammonium chloride solution. Normal Tγ cells were heterogeneous with regard to their granules; the majority of Tγ cells had parallel tubular arrays (PTA) and a few had electron-dense granules. When ammonium chloride solution was employed to lyse SRBC, PTA were never observed; PTA in normal Tγ cells and in chronic lympho-cytic leukemia cells with Tγ character both seemed to change into electron-dense granules after ammonium chloride treatment. In contrast to Tγ cells, Tμ cells were characterized by clustered dense bodies, i.e. focal aggregates of electron-dense granules.

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Section: Discussionmentioning

confidence: 99%

Ultrastructure of Normal Human T Cell Subpopulations

Kanayama¹,

Hiraoka²,

Konishi³

et al. 1983

Acta Haematol

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Adult T-cell leukemia in Japan: An ultrastructural study

Shamoto¹,

Murakami²,

Zenke³

1981

Cancer

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An electron microscopic study of adult T-cell leukemia, which might be a new distinct disease entity of T-cell malignancies, is presented. The most characteristic feature of adult T-cell leukemia was an extremely irregular nucleus with condensed heterochromatin in the nuclear periphery, the greater part of which was very similar to the small-cell variant form of Sézary syndrome, although some nuclei were similar to normal-appearing lymphocytes or atypical lymphoid cells with slightly indented nuclei or Sézary cells. Nuclear pockets containing tubuloreticular structures and filamentous structures etc., were also characteristic. Regarding the cytoplasmic features, the appearance of clustered dense bodies seemed to be a distinguishing feature of adult T-cell leukemia. Tubuloreticular structures were also observed in some cases. The nature of the test tube-shaped or ring-shaped forms in rough endoplasmic reticulum, which appeared in one case, is not clear.

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Lymphocytosis of large granular lymphocytes in patients with hodgkin's disease

Kingreen¹,

Dalal

Heyman

et al. 1995

American J Hematol

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Clonal disorders of large granular lymphocytes (LGL) of either CD3- (NK cell) or CD 3+ (T-cell) phenotype have been described. B-cell malignancies such as hairy cell leukemia and non-Hodgkin's lymphoma have been observed in association with the T-cell type of LGL leukemia. Here we report the occurrence of LGL lymphocytosis in four patients with Hodgkin's disease. Immunophenotyping studies showed that these LGL were CD 3- in three patients and CD3+ in the other. LGL were polyclonally expanded in both patients in whom clonality could be assessed.

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Parallel Tubular Structures in Lymphocytes

Cited by 14 publications

References 8 publications

Ultrastructure of Normal Human T Cell Subpopulations

Ultrastructure of Normal Human T Cell Subpopulations

Adult T-cell leukemia in Japan: An ultrastructural study

Lymphocytosis of large granular lymphocytes in patients with hodgkin's disease

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