Paralysis in hedgehogs (<i>Erinaceus europaeus</i>) associated with demyelination

Palmer, Alan M.; Blakemore, WF; Franklin, R. J. M.; Frost, Lorraine; Gough, R. E.; Lewis, John; MacDougall, Danielle; O'Leary, Marion T.; Stocker, L. R.

doi:10.1136/vr.143.20.550

Cited by 21 publications

(28 citation statements)

References 4 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…15 In this case there was no correlating clinicopathologic abnormality, so the histological findings were considered insignificant. The demyelination found in the central nervous system (CNS) was similar to that described in other cases of paralysis in hedgehogs 9 and provides a plausible explanation for the clinical signs. The de- Figure 2.…”

mentioning

confidence: 54%

Rib Osteoblastic Osteosarcoma in an African Hedgehog (Atelerix Albiventris)

et al. 2006

View full text Add to dashboard Cite

Abstract.A 3-year-old African hedgehog (Atelerix albiventris) was presented to the Exotic Animal Clinic of the University of Montreal for evaluation of a mass growing on the right thoracic wall. The diagnostic workup, which included helical computed tomography, confirmed the presence of a large mass, originating from the right 7th rib, infiltrating the thoracic wall and cavity. The animal was euthanized due to the poor prognosis. At necropsy, a well-demarcated mass penetrated the thoracic wall and incorporated the 6th to 8th ribs. Cut sections of the tumor were white, glistening, firm, and gritty. Microscopically, it was composed of polyhedral to elongated cells with interspersed trabeculae of osteoid and large areas of coagulative necrosis. On the basis of histopathologic findings, a diagnosis of osteoblastic osteosarcoma was made. To the authors' knowledge, this is the first report of an osteoblastic osteosarcoma on the thoracic wall of an African hedgehog, as well as the first report of the use of helical computed tomography in that species.

show abstract

mentioning

confidence: 54%

Rib Osteoblastic Osteosarcoma in an African Hedgehog (Atelerix Albiventris)

et al. 2006

View full text Add to dashboard Cite

show abstract

“…Postmortem examination of 14 hedgehogs (Erinaceus europaeus) affected by paraplegia revealed demyelination in the brain and spinal cord and an inflammatory response in the meninges, choroid plexus and CNS. In the spleen, lungs and liver there was an accumulation of megakaryocytes and other evidence of extramedullary haemopoiesis (Palmer et al 1998).…”

Section: Discussionmentioning

confidence: 99%

Morphology of Adrenal Gland and Lymph Organs is Impaired in Neurodeficient Lurcher Mutant Mice

Beranova¹,

Mandakova²,

Šíma³

et al. 2002

Acta Vet. Brno

View full text Add to dashboard Cite

Beranová M., P. Manìáková, P. ·íma, J. Slípka, F. VoÏeh, J. Koãová, M. âervinková, J. S˘kora: Morphology of Adrenal Gland and Lymph Organs is Impaired in Neurodeficient Lurcher Mutant Mice. Acta Vet. Brno 2002, 71: 23-28. There is a tight structural relation and functional co-operation between the nervous, endocrine and immune systems. A dense network of soluble neuro-endocrine and immune mediators exists to ensure close interactions. These hormones, cytokines and neurotransmitters all interact through positive and negative feed-forward and feedback loops. The mediators, once considered specific to the central nervous system (CNS), the endocrine system (ES) or the immune system (IS), do in fact act in all three systems, forming that way the united neuro-endocrine-immune system. The complex neuro-endocrine-immune networks operate under both physiological and pathological conditions.In the presented study microscopical analyses of selected immune organs (the thymus, spleen, inguinal and subscapular lymph nodes) and of the adrenal gland of the neurodeficient Lurcher mutant mice and control C3H mice were performed. In the neurodeficient mice the morphology of the immune organs was impaired. The changes followed in the spleen, especially the increased number of megakaryocytes, lead to the hypothesis of enhanced extramedullar hemopoiesis in the neurodeficient Lurcher mutant mice. Histopathological analysis of the adrenal gland showed the relative hypertrophy of the adrenal medulla. Regarding the adrenal cortex, the three cortical zones, zona glomerularis, fasciculata and reticularis, are difficult to be distinguished. It has been supposed that structural changes of adrenal medulla could document the increased secretion of catecholamines in the neurodeficient animals.Our observations confirm the idea of the tight cooperation of neuro-endocrine-immune structures and contribute to its better understanding, specifically in the conditions of postnatally progressing neurodeficiency. Lurcher mutant mice, homeostatic relatioships, neuro-endocrine-immune system, adrenal gland, megakaryocytesThe intrinsic condition for the individual survival is a balance of the internal enviromenthomeostasis. There are many proofs of the existence of a unified neuro-endocrine-immune regulatory system that is responsible for maintaining the homeostasis (Michael and Chapman 1990;Weigent and Blalock 1995;Besedovsky et al. 1983). The regulatory relations within that system are mutual and complex (Jankovic 1989;Csaba 1994; ·íma and Vûtviãka 1990;Provinciali and Fabris 1991;Pertseva 1991; Slípka 1961).To contribute to the explanation of these relations we used in our previous study "an experiment of the nature", gross-brain malformation -anencephaly -which eliminates the central nervous system and consequently the neuro-endocrine part of the homeostatic system (Slípka et al. 1997; B e ranová 1994). The spontaneously aborted human foetuses without any external malformation and human anencephalic foetuses were compared with

show abstract

“…This disease has been reported in African [4] and European hedgehogs [11]. Clinically, WHS begins with mild ataxia and progresses to more severe neurologic signs such as falling consistently to one side, tremors, scoliosis, seizures, muscle atrophy, dysphagia, emaciation, ascending paresis or tetraparesis, and, rarely, self-mutilation.…”

mentioning

confidence: 99%

“…This condition has been reported as wobbly hedgehog syndrome (WHS) in both the African and European hedgehog species recently [2,4,11]. The onset of WHS commonly occurs under 2 years of age, and the characteristic histopathology of WHS is vacuolization of white matter of the brain and spinal cord, and associated neurogenic muscle atrophy.…”

mentioning

confidence: 99%

See 1 more Smart Citation

Astrocytoma in an African Hedgehog (Atelerix albiventris) Suspected Wobbly Hedgehog Syndrome

et al. 2011

View full text Add to dashboard Cite

ABSTRACT. A 28-month-old African hedgehog was referred to our hospital with progressive tetraparesis. On the first presentation, the hedgehog was suspected as having wobbly hedgehog syndrome (WHS) and the animal was treated with medication and rehabilitation. The animal died 22 days after onset. Pathological examination revealed that the animal was involved in astrocytoma between the medulla oblongata and the spinal cord (C1). This report indicates that a primary central nervous system tumor should be considered as one of the differential diagnoses for hedgehogs presenting with progressive paresis, together with WHS.

show abstract

Paralysis in hedgehogs (Erinaceus europaeus) associated with demyelination

Cited by 21 publications

References 4 publications

Rib Osteoblastic Osteosarcoma in an African Hedgehog (Atelerix Albiventris)

Rib Osteoblastic Osteosarcoma in an African Hedgehog (Atelerix Albiventris)

Morphology of Adrenal Gland and Lymph Organs is Impaired in Neurodeficient Lurcher Mutant Mice

Astrocytoma in an African Hedgehog (Atelerix albiventris) Suspected Wobbly Hedgehog Syndrome

Contact Info

Product

Resources

About