Paramagnetic nanoparticles as potential MRI contrast agents: characterization, NMR relaxation, simulations and theory

Vuong, Quoc Lam; Doorslaer, Sabine Van; Bridot, Jean-Luc; Argante, Corradina; Alejandro, G.; Hermann, Raphaël P.; Disch, Sabrina; Mattea, Carlos; Stapf, Siegfried; Gossuin, Yves

doi:10.1007/s10334-012-0326-7

Cited by 43 publications

(24 citation statements)

References 57 publications

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“…In this case relaxation theory for a single centre is not adequate a priori. On the other hand, the observed PREs differ also from typical observations in superparamagnetic clusters and nanoparticles, 11,18,19 therefore the models for the description of PRE of these moieties cannot be applied directly to the data in Fig. 2.…”

Section: Resultsmentioning

confidence: 67%

Characterisation and application of ultra-high spin clusters as magnetic resonance relaxation agents

et al. 2015

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In Magnetic Resonance Tomography (MRT) image contrast can be improved by adding paramagnetic relaxation agents such as lanthanide ions. Here we report on the use of highly paramagnetic isostructural Fe(III)/4f coordination clusters with a [Fe10Ln10] core to enhance relaxation. Measurements were performed over the range of (1)H Larmor frequencies of 10 MHz to 1.4 GHz in order to determine the relevant parameters for longitudinal and transverse relaxivities. Variation of the lanthanide ion allows differentiation of relaxation contributions from electronic states and molecular dynamics. We find that the transverse relaxivities increase with field, whereas the longitudinal relaxivities depend on the nature of the lanthanide. In addition, the Gd(III) analogue was selected in particular to test the interaction with tissue observed using MRT. Studies on biofilms used in waste water treatment reveal that the behaviour of the high-spin clusters is different from what is observed for common relaxation agents with respect to the penetration into the biofilms. The Fe10Gd10 cluster adheres to the surface of the biofilm better than the commercial agent Gadovist.

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Section: Resultsmentioning

confidence: 67%

Characterisation and application of ultra-high spin clusters as magnetic resonance relaxation agents

et al. 2015

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“…The trend for the P22-Gd 3+ capsids from usual T 1 CA behavior at 0.49 T to T 2 CA values at 7 T suggests susceptibility effects from spatially confined Gd 3+ ions. However, the susceptibility effects were significantly weaker than for typical iron oxide superparamagnetic nanoparticles [24]. Nanoparticle susceptibility effects are attributed to T 2 outer sphere relaxation of superparamagnetic agents ( r 2 / r 1 >10).…”

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confidence: 99%

Gadolinium-Loaded Viral Capsids as Magnetic Resonance Imaging Contrast Agents

et al. 2015

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Polymeric nanohybrid P22 virus capsids were used as templates for high density Gd3+ loading to explore magnetic field-dependent (0.5–7.0 T) proton relaxivity. The field-dependence of relaxivity by the spatially constrained Gd3+ in the capsids was similar when either the loading of the capsids or the concentration of capsids was varied. The ionic longitudinal relaxivity, r1, decreased from 25–32 mM−1 s−1 at 0.5 T to 6–10 mM−1 s−1 at 7 T. The ionic transverse relaxivity, r2, increased from 28–37 mM−1 s−1 at 0.5 T to 39–50 mM−1 s−1 at 7 T. The r2/r1 ratio increased linearly with increasing magnetic field from about 1 at 0.5 T, which is typical of T1 contrast agents, to 5–8 at 7 T, which is approaching the ratios for T2 contrast agents. Increases in electron paramagnetic resonance line widths at 80 and 150 K and higher microwave powers required for signal saturation indicate enhanced Gd3+ electron spin relaxation rates for the Gd3+-loaded capsids than for low concentration Gd3+. The largest r2/r1 at 7 T was for the highest cage loading, which suggests that Gd3+–Gd3+ interactions within the capsid enhance r2 more than r1.

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“…The second major group consists of paramagnetic and super paramagnetic contrast agents based on iron oxide nanoparticles that have strong T2/T2*-negative effects. 33,34 The cardiac MRI detection of labeled stem cells is affected by MRI sequence, intracellular iron distribution, magnetic field intensity, spatial resolution, and surrounding tissue heterogeneity. 35 The use of paramagnetic/superparamagnetic iron oxide particles in stem cell tracing has been demonstrated to be associated with a high sensitivity and specificity.…”

Section: Stem Cell Tracking With Cmrimentioning

confidence: 99%

Magnetic Resonance Imaging of Myocardial Function Following Intracoronary and Intramyocardial Stem Cell Injection

Mester

Oltean-Péter

Rodean³

et al. 2017

Journal of Interdisciplinary Medicine

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Stem cell-based therapy is a new therapeutic option that can be used in patients with cardiac diseases caused by myocardial injury. Cardiac magnetic resonance imaging (MRI) is a new noninvasive imaging method with an increasingly widespread indication. The aim of this review was to evaluate the role of cardiac MRI in patients with myocardial infarction undergoing stem cell therapy. We studied the role of MRI in the assessment of myocardial viability, stem cell tracking, assessment of cell survival rate, and monitoring of the long-term effects of stem cell therapy. Based on the current knowledge in this field, this noninvasive, in vivo cardiac imaging technique has a large indication in this group of patients and plays an important role in all stages of stem cell therapy, from the indication to the long-term follow-up of patients.

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Paramagnetic nanoparticles as potential MRI contrast agents: characterization, NMR relaxation, simulations and theory

Cited by 43 publications

References 57 publications

Characterisation and application of ultra-high spin clusters as magnetic resonance relaxation agents

Characterisation and application of ultra-high spin clusters as magnetic resonance relaxation agents

Gadolinium-Loaded Viral Capsids as Magnetic Resonance Imaging Contrast Agents

Magnetic Resonance Imaging of Myocardial Function Following Intracoronary and Intramyocardial Stem Cell Injection

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