Paraneoplastic Raynaud phenomenon associated with metastatic ovarian cancer: A case report and review of the literature

Paraneoplastic Raynaud’s Phenomenon as an Initial Manifestation of Lung Cancer?

“…Secondary Raynaud's phenomenon in the absence of autoimmune or vascular aetiology should prompt investigations for an underlying malignancy. Raynaud's phenomenon can develop during any phase of cancer and also during treatment [2,3] . The mainstay of treatment remains calcium channel blockers (e.g., nifedipine), losartan, fluoxetine and captopril.…”

“…Prazosin has been tried successfully, and iloprost has been described as beneficial for paraneoplastic Raynaud's phenomenon. Cervicothoracic sympathectomy or localized digital sympathectomy have also been tried for paraneoplastic Raynaud's phenomenon [1,2] . Similar cases in the literature include a 54-year-old man with Raynaud's phenomenon and right lung adenocarcinoma, whose symptoms improved after chemotherapy [3] , and a 62-year-old man who sought attention for severe Raynaud's phenomenon and was found to have non-small cell lung cancer, whose symptoms also resolved after chemotherapy [4] .…”

Raynaud's Phenomenon: Beware of Cancers!

“…Paraneoplastic causes are rarely reported - 68 cases in Guigne's study and 33 cases in Schildmann's study - it is often a pulmonary, mammary, uterine, or ovarian site [ 1 - 2 ]. The dominant histological type is adenocarcinoma [ 3 ].…”

“…Protective measures, prostacyclin analogs, and calcium channel blockers are the treatment of choice for idiopathic forms; otherwise, the management is that of the cause. Regarding paraneoplastic Raynauds, the regression of the phenomenon after treatment of the tumor was noted in 48% of cases [ 1 , 6 ].…”

Diagnostic Dilemma of Paraneoplastic Rheumatic Disorders: Case Series and Narrative Review

“…Some of the paraneoplastic RP characteristics are similar to the characteristic presentation of secondary RP: unusual episodes, asymmetrical distribution, pain in nature, ischemic complications, and occur in those more than 50 years of age [ 38 ]. It can present in any stage of cancer and may be associated with disease activity, given the improvement of symptoms that may be seen after successfully treating underlying cancer [ 39 ]. In our case #3 of vascular and undifferentiated paraneoplastic RD, the patient had a history of stable RP with subsequent development of a necrotic erythematous rash, lobular panniculitis, vasculitic neuropathy, and positive anti-dsDNA antibodies without ANA antibodies.…”