Paraoxonase Activity in Prehypertension and its Relation to Oxidative Stress

Saxena, Tripti; Agarwal, B.K.; Sharma, Varsha; Naz, Sabiha; Lanke, Pooja

doi:10.13005/bpj/432

Cited by 2 publications

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“…This finding correlates with study done by Saxena T et al that showed the increased oxidative stress and decreased antioxidant activity in Pre HTN subjects. 13 Our study coincides with the study done by Bhavanani AB et al which showed immediate effect of Sukha Pranayam on cardiovascular variables in patients of hypertension. 14 Bhavanani AB et al studied immediate effects of performing pranava pranayama on cardiovascular parameters in hypertensive patients.…”

Section: Discussionsupporting

confidence: 92%

Pranayama-an alternative supportive therapy against oxidative stress in essential hypertension

2015

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Background: Essential hypertension is one of the most prevalent diseases of the world. The underlying pathophysiological abnormalities that lead to the development of the elevated arterial pressure in this disorder remain elusive. Pranayam (yogic breathing exercises) techniques are beneficial in treating a range of stress related disorders such as hypertension and reducing signs of oxidative stress. The present study was undertaken to check effect of Pranayam on oxidative stress in cases of essential hypertension before and after Pranayam. Methods: Total 100 hypertensive subjects and 100 sex matched controls were enrolled in this study. Inclusion criteria include patients with blood pressure ≥ 140/90 mm of Hg, while patients with secondary hypertension, stroke, CAD, MI and diabetes mellitus were excluded. Serum PON-1 was estimated spectrophotometrically by Charlton Menys.V method. Serum SOD estimated spectrophotometrically by Mishra H.P. & Fridovich I,1972 method and Plasma MDA by colorimetric method of Satoch K.et al. We estimated PON-1, SOD and MDA in hypertensive and controls, then we suggested hypertensive for 3 months Pranayam, again the same parameters were measured and compared by using Students T test and one way ANOVA to determine significant differences. Results: Before Pranayam, PON-1 activity was decreased significantly (<0.001) in hypertensive subjects compared to controls. SOD was also decreased significantly (p<0.001) in hypertensives compared to controls and MDA was increased significantly (p<0.001) in hypertensives compared to controls, But after 3 months Pranayam, there was significant (p<0.001) improvement in PON-1 and SOD activity in hypertensives and significant (p<0.001) decrease in MDA levels in hypertensives compared to hypertensives before Pranayam. Conclusions: It is concluded that Pranayam can significantly reduce oxidative stress i.e. generation of free radicals, lipid peroxidation products (MDA) and significant increase in the level of antioxidant enzymes i.e. SOD & PON-1.MDA is a marker of oxidative stress. Pranayam not only reduces oxidative stress but also improves antioxidant status of the individual.

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Section: Discussionsupporting

confidence: 92%

Pranayama-an alternative supportive therapy against oxidative stress in essential hypertension

2015

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“…These results were in accordance with Saxena T et al, who noted that MDA level was significantly (p<0.001) increased in prehypertensive obese than nonobese as compared with control group. 30 Laboratory tests of overweight subjects (BMI>25) indicate a higher oxidative stress than in subjects with BMI<25. 31 In the present study S. uric acid and S. MDA were significantly and positively correlated with BMI ( Figure 1, Figure 2), SBP, total cholesterol (TC) and triglycerides (p <0.001).…”

Section: Discussionmentioning

confidence: 99%

A correlative study of body mass index with oxidative stress parameters (serum uric acid and serum malondialdihyde) in essential hypertension

2019

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Background: Hypertension is most commonly documented modifiable risk factor for cardiovascular diseases. A growing body of data proposes an appreciated pathogenic role of an elevated serum uric acid in atherosclerosis and cardiovascular disease (CVD). Increased oxidative stress could be involved in the pathogenesis of hypertension. Oxidative stress marker, serum uric acid (SUA) and serum malondialdyhyde level (S. MDA) are affected by both genetic and environmental factors and related to biological factors as gender, age and body mass. So, the aim of the study is to access the association of body mass index (BMI) with oxidative stress parameters in essential hypertension (EHT).Methods: For the said purpose, this case control study was carried out on a total of 200, age and sex matched 75 hypertensives, 75 prehypertensive and 50 healthy subjects. After diagnosis of cases, SUA was estimated by standard kit method and S. MDA was estimated manually by Buege and Aust method.Results: This study represents that systolic and diastolic blood pressure were increased with increased BMI in all groups. Oxidative stress marker, SUA and S. MDA level increased significantly with increasing BMI in all groups and were positively correlated.Conclusions: Our study indicates that monitoring of the blood pressure, SUA and S. MDA at regular interval and maintaining of the oxidative balance would be helpful in preventing the development of hypertension and associated cardio-vascular morbidities.

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Paraoxonase Activity in Prehypertension and its Relation to Oxidative Stress

Cited by 2 publications

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Pranayama-an alternative supportive therapy against oxidative stress in essential hypertension

Pranayama-an alternative supportive therapy against oxidative stress in essential hypertension

A correlative study of body mass index with oxidative stress parameters (serum uric acid and serum malondialdihyde) in essential hypertension

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