Objective: to study the clinical and demographic characteristics of patients and risk factors, to analyze their influence on the frequency of infection of artificial vascular prostheses in the aortoiliac-femoral segment. Material and methods. We analyzed 609 medical records of inpatient patients who had undergone vascular reconstructive interventions on the aortoiliac-femoral segment using a synthetic vascular prosthesis. The article presents the clinical and demographic characteristics of patients with lesions of the aortoiliac-femoral segment. The frequency of conduit infection in various major diseases, surgical approaches, types of bypass surgery (prosthetics), types of artificial vascular prosthesis was analysed. Results. The patients who developed lesions of the aortoiliac-femoral segment were mostly males (94.6%), urban residents (78%), unemployed (68.6%), those with chronic obliterating diseases of the arteries of the lower extremities (72.7%) and coronary heart disease (59.4%). The incidence of vascular prostheses in patients with chronic obliterating diseases of the arteries of the lower extremities was 5.5%, and in those with an aneurysm of the infrarenal abdominal aorta – 1.2%. Conclusion. The pattern of developing artificial vascular prosthesis infection has been established. Infection of conduits occurs statistically significantly more often in patients with chronic obliterating diseases of the arteries of the lower extremities than in those with an aneurysm of the infrarenal abdominal aorta.