Parasite and the Circulating Pool- Characterisation of Leukocyte Number and Morphology in Malaria

Kini, Reshma G; Chandrashekhar, Jayaprakash

doi:10.7860/jcdr/2016/16425.7887

Cited by 10 publications

(13 citation statements)

References 19 publications

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“…In the present study, total leukocyte count in study participants, nearly 23% of the patients had total leukocyte count < 4 × 10 3 /µL (leucopenia), 70.6% had 4-11 × 10 3 /µL and 6.7% had counts > 11 × 10 3 / µL (leukocytosis) similar to the study done in Iran and western India (8,57). Another congruent study was done in a tertiary care Hospital in Western Maharashtra.…”

Section: Comparisons Of Hematological Parameters Among Cases and Contsupporting

confidence: 83%

“…Eosinophil was statistically decreased in malarial patients than health controls in line with a study conducted in southern India (57) in contrast with previous study (58). This difference might be due to the method for eosinophil count because in this study eosinophil was counted by manually but in the previous study it was counted by hematology analyzer.…”

Section: Comparisons Of Hematological Parameters Among Cases and Contsupporting

confidence: 52%

“…These variations in the leukocyte numbers is might to be dependent on many factors including the acuteness of infection, the parasitaemia level, the severity of the disease, state of host immunity to malaria and concurrent infections (57).…”

Section: Comparisons Of Hematological Parameters Among Cases and Contmentioning

confidence: 99%

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Hematological parameters of malaria infected adult patients in Raya Alamata Hospital, Northeast Ethiopia.

Asmerom

Yalew

Getaneh

2019

Preprint

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Background: Hematological changes are the most common complications encountered in malaria and they play a major role in malaria pathology. Hematological changes like red blood cells, platelets and leukocytes have been observed in patients with malaria. Therefore, this study aimed to compare hematological parameters of malaria infected adult patients in Alamata Hospital, Northeast Ethiopia from February 01- April 30, 2019. Methods: Comparative cross sectional study was used to compare the hematological parameters on a total of 238 study participants, consisting of 119 malaria infected patients and 119 malaria negative controls at Raya Alamata Hospital. Malaria diagnosis was done based on thick and thin blood films microscopy. Hematological parameters were determined by using an automated, DiRUi BCC/3000B hematology analyzer. Malaria parasite density was determined by counting the asexual parasites against 200 WBCs, and then calculated by using the standard formula. Data for the different hematological parameters were expressed as mean (±SD). Independent t-test was used for comparison the hematological parameters between the two groups. Binary logistic regression model was constructed for categorical dependent variables to see associations between predictors and outcomes. Results: In current study parameters like red blood cells count, hemoglobin, mean corpuscular volume, platelets count, and eosinophil counts were significantly lowered in malaria-infected patients than the controls. The prevalence of anemia and thrombocytopenia in malaria patients was 39.5% and 56.3%, respectively. Being female and malaria parasitaemia were found significantly associated with thrombocytopenia. The odds of developing thrombocytopenia with high malaria parasitaemia were 8.4 times more likely develop thrombocytopenia.Conclusion: Anemia and thrombocytopenia were the two common hematological abnormalities seen in malaria patients. The platelet count during malaria infection was inversely correlated with the parasitaemia. Malaria patients should be checked for the presence of hematological abnormalities such as anemia and have to be managed for those abnormalities. Keywords: Malaria, Malaria parasitaemia, Hematological parameters, Ethiopia

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Section: Comparisons Of Hematological Parameters Among Cases and Contsupporting

confidence: 83%

Section: Comparisons Of Hematological Parameters Among Cases and Contsupporting

confidence: 52%

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Hematological parameters of malaria infected adult patients in Raya Alamata Hospital, Northeast Ethiopia.

Asmerom

Yalew

Getaneh

2019

Preprint

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“…That said, greater focus is given to CMML, as it is the most common neoplastic diagnosis made once other rare and/or genetically defined entities have been excluded. Chronic infections (eg, viral, tuberculosis, malaria, subacute bacterial endocarditis, and congenital syphilis) [21][22][23][24] Immune/inflammatory disorders (eg, collagen vascular diseases, inflammatory bowel disease, sarcoidosis, and immune thrombocytopenia) 21,25,26 Myocardial infarction 27 Sickle cell disease and other hemolytic anemias 28,29 Chronic stress 30…”

Section: Neoplastic Monocytosismentioning

confidence: 99%

How I investigate monocytosis

Lynch

Hall

Foucar

2018

Int J Lab Hematology

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Monocytosis is a common finding that is caused by a wide variety of neoplastic and non-neoplastic conditions. The adequate evaluation of monocytosis involves the integration of laboratory data, morphology, clinical findings, and the judicious use of ancillary studies. We review the literature on monocytosis, including the 2017 revised 4th edition of the World Health Organization classification of hematopoietic neoplasms.We present a review of monocytosis with practical guidelines on how to approach both routine and challenging cases. K E Y W O R D Sblood, bone marrow, leukemia, monocytes, morphology, myeloid | INTRODUCTIONCirculating peripheral blood monocytes are key players in the innate immune system. Although not distinct morphologically, dendritic cells and precursors also circulate. These monocytic/dendritic cells are derived primarily from bone marrow hematopoietic stem cells and are highly versatile with capacity to migrate to sites of inflammation, differentiate into tissue macrophages and specialized dendritic cell subtypes, secrete cytokines and chemokines to attract other inflammatory cells, and phagocytose tissue debris and microorganisms. They also participate in the initiation of adaptive immunity by presenting antigens to antigen-specific lymphocytes. The effector functions and roles played by these cells in mediating acute and chronic inflammation, antimicrobial defense, and tissue repair and wound healing are vital to the maintenance of a healthy steady state. When dysfunctional or dysregulated, however, monocytes can contribute to and cause significant disease. The purpose of this review was present a strategy to investigate monocytosis primarily in the adult patient. | BACKGROUNDIn the healthy adult and child, monocytes typically comprise between 1 and 9 percent of total peripheral blood leukocytes, with the absolute

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“…Leukocyte alterations are a common hematological alteration among malaria patients [7,[10][11][12][13][14][15][16][17][18]. Previous studies have described leukopenia during malarial infection [7,[11][12][13][14][15]18]. However, some studies observed leukocytosis during malarial infection [10,16,17].…”

Section: Introductionmentioning

confidence: 99%

Reduction in total leukocytes in malaria patients compared to febrile controls: A systematic review and meta-analysis

Kotepui

Milanez

et al. 2020

PLoS ONE

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Background Leukocyte alterations are a common hematological alteration among malaria patients. Objectives This systematic review and meta-analysis aimed to provide data and evidence comparing alterations in total leukocyte counts in malaria patients compared to febrile/healthy subjects at baseline before treatment. A systematic review was conducted by following the Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA) statement for reporting systematic reviews and meta-analyses. Data sources Web of Science (ISI), Scopus, and Medline. Study eligibility criteria, participants, and interventions All published articles reporting a total leukocyte count of patients infected with malaria, nonmalaria (febrile or healthy group) at baseline before treatment before August 27, 2019, were retrieved, and data were extracted by two main reviewers independently. Study appraisal and synthesis methods We used a forest plot, heterogeneity test (Cochran's Q), and the degree of heterogeneity (I 2) to test whether the included studies were heterogeneous. The quality of the included studies was determined by a quality assessment guide based on the quality assessment tool developed by the Newcastle-Ottawa Scale (NOS). Cochran's Q (Chi-square) and Moran's I 2 were used to evaluate heterogeneity. Meta-regression using STATA software was conducted to find the source of heterogeneity. A funnel plot with Egger's test was used to examine the significance of publication bias among the included studies. The mean differences were estimated using a random-effects model.

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Parasite and the Circulating Pool- Characterisation of Leukocyte Number and Morphology in Malaria

Cited by 10 publications

References 19 publications

Hematological parameters of malaria infected adult patients in Raya Alamata Hospital, Northeast Ethiopia.

Hematological parameters of malaria infected adult patients in Raya Alamata Hospital, Northeast Ethiopia.

How I investigate monocytosis

Reduction in total leukocytes in malaria patients compared to febrile controls: A systematic review and meta-analysis

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