Parasympathetic neurons in the human submandibular ganglion

Kawashima, Mutsuko; Yajima, Takahiro; Tachiya, Daisuke; Kokubun, Souichi; Ichikawa, Hiroyuki; Sato, Tadasu

doi:10.1016/j.tice.2021.101496

Cited by 10 publications

(7 citation statements)

References 39 publications

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“…The function of the lingual nerve is to provides tactile sensory innervation to the ipsilateral aspect of the tongue, the lower lingual gingivae, and therefore the floor of the mouth [9]. It is responsible on the taste sensation of the anterior twothirds of the tongue which is carried on the chorda tympani branch of the facial nerve [10] and secretomotor innervation to the submandibular ganglion via preganglionic parasympathetic fibers [11]. The lingual nerve is prone to compression because it travels between the pterygoids or between the medial pterygoid and the mandible [6].…”

Section: Discussionmentioning

confidence: 99%

Atypical Neuralgia of Lingual Nerve after General Anesthesia: A Case Report

Al-Ramzi

Adel

Kassem

2023

EJDENT

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Objectives: Injury of lingual nerve is a rare complication of general anesthesia. The causes of lingual nerve injury following general anesthesia are multifactorial; possible mechanisms may include difficult laryngoscopy, prolonged anterior mandibular displacement, improper placement of the oropharyngeal airway, macroglossia and tongue compression. Case Report: A case of atypical neuralgia of lingual nerve that was associated with orotracheal intubation for 54 years old female. Treatment: Carbamazepine was effectively aided the recovery of the injured lingual nerve. Conclusion: Lingual nerve injury following orotracheal intubation is rare but can cause irritation to patients.

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Section: Discussionmentioning

confidence: 99%

Atypical Neuralgia of Lingual Nerve after General Anesthesia: A Case Report

Al-Ramzi

Adel

Kassem

2023

EJDENT

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“…In the internal carotid ganglion, neuronal cells are not IR for DBH and TH (Suzuki & Hardebo, 1991). They contain choline acetyltransferase and, SP and CGRP, markers for parasympathetic and sensory neurons, respectively (Kawashima et al, 2021; Suzuki & Hardebo, 1991). The present immunohistochemical analysis demonstrated that neuronal cells in the human ICN contained DBH‐, TH‐, NPY‐ and VIP‐immunoreactivity.…”

Section: Discussionmentioning

confidence: 99%

“…Following nickel ammonium sulfate‐intensified diaminobenzidine reaction, they were dehydrated in a graded series of alcohols, cleared in lemosol and cover‐slipped with Softmount (Wako Pure Chemical Industries, Ltd., Japan) (Liu et al, 2020; Suzuki et al, 2012). The specificity of primary antibodies has been described elsewhere (Atsumi et al, 2020; Kawashima et al, 2021).…”

Section: Methodsmentioning

confidence: 99%

Distribution of neuronal cells which contain dopamine β‐hydroxylase, tyrosine hydroxylase, neuropeptide Y and vasoactive intestinal polypeptide in the human internal carotid nerve

Sato

Yajima

Kokubun

et al. 2021

The Anatomical Record

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The human internal carotid nerve (ICN) occasionally has a swelling beneath the external opening of the carotid canal. In this study, the presence and distribution of neuronal cells were investigated in the bilateral ICNs of nine human cadavers. Among 44.4% of the cadavers, swellings were detected in the ICN. Their diameters ranged from 1.7 to 3.6 mm (average ± SD = 2.6 ± 0.7 mm). Thirty‐eight percent of these swellings were large (diameter > 3 mm) and showed an oval shape. The large swelling contained many neuronal cells. However, the ICNs with or without a swelling <3 mm diameter were mostly free from neuronal cells (93.3%). Only in one human cadaver, the right ICN without a swelling had a small number of neuronal cells. By the present immunohistochemical method, ICN neurons contained catecholamine‐synthesizing enzymes and neuropeptides. Dopamine‐beta hydroxylase‐ and tyrosine hydroxylase‐immunoreactivity were mostly expressed by ICN neurons. More than half of them also contained neuropeptide Y‐immunoreactivity. However, vasoactive intestinal polypeptide‐immunoreactive ICN neurons were relatively infrequent. Substance P‐ and calcitonin gene‐related peptide‐immunoreactive ICN neurons could not be detected. By the cell size analysis, neuropeptide Y‐immunoreactive neurons were significantly smaller than neuropeptide Y‐immunonegative neurons in the ICN. The present study suggests that ICN neurons have a sympathetic function in the human.

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“…Sections were viewed with a conventional fluorescence microscope (ECLIPSE 80i, Nikon, Japan) or a confocal laser scanning microscope (A1+, Nikon). The specificity of antibodies against GAL, CGRP, CD11b, ED1, and PGP9.5 has been described elsewhere 22 , 46 – 50 . To check inappropriate reaction with the primary and secondary antibodies, TSA and double immunofluorescence methods were performed without either one or all of primary antibodies.…”

Section: Methodsmentioning

confidence: 99%

Distribution and possible function of galanin about headache and immune system in the rat dura mater

Shimazaki

Yajima

Ichikawa

et al. 2022

Sci Rep

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Galanin (GAL) is a nociceptive transmitter or modulator in the trigeminal sensory system. In this study, GAL expression was investigated in the rat dura mater to demonstrate its possible function in headache using immunohistochemical techniques. The cerebral falx and cerebellar dura mater received abundant blood and nerve supply, and were significantly thicker compared to other portions in the cerebral dura mater. GAL-immunoreactivity was expressed by cell and nerve fiber profiles. Presumed macrophages and dendritic cells contained GAL-immunoreactivity, and co-expressed with CD11b-immunoreactivity. Many isolated and perivascular nerve fibers also showed GAL-immunoreactivity. In addition, GAL-immunoreactive nerve fibers were present in the vicinity of macrophages and dendritic cells with either GAL- or ED1-immunoreactivity. GAL-immunoreactive cells and nerve fibers were common in the cerebral falx and cerebellar dura mater and infrequent in other portions. And, GAL-immunoreactive nerve fibers usually co-expressed calcitonin gene-related peptide (CGRP)-immunoreactivity. In the trigeminal ganglion, a substantial proportion of sensory neurons innervating the dura mater contained GAL-immunoreactivity (mean ± SD, 3.4 ± 2.2%), and co-expressed CGRP-immunoreactivity (2.7 ± 2.1%). The present study may suggest that GAL is associated with nociceptive transduction or modulation in the dura mater. GAL also possibly plays a role in the immune mechanism of the dura mater.

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Parasympathetic neurons in the human submandibular ganglion

Cited by 10 publications

References 39 publications

Atypical Neuralgia of Lingual Nerve after General Anesthesia: A Case Report

Atypical Neuralgia of Lingual Nerve after General Anesthesia: A Case Report

Distribution of neuronal cells which contain dopamine β‐hydroxylase, tyrosine hydroxylase, neuropeptide Y and vasoactive intestinal polypeptide in the human internal carotid nerve

Distribution and possible function of galanin about headache and immune system in the rat dura mater

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