Parathyroid hormone and enamel formation in rat maxillary incisors

Abstract

– Parathyroid hormone (PTH) plays an important role in regulating calcium in serum. It is also known to affect bone and dentin formation. The purpose of this investigation was to evaluate enamel formation in normal rats receiving added PTH. It is in two parts: a pilot study where a known method was tested, followed by the main study where the rats were given different doses of PTH. The enamel was examined in both studies and in the main study the ameloblasts were also investigated. Contradictory results were seen. In the pilot study, severe enamel aberrations occurred, while no divergence from normal amelogenesis was noted in the main study. A factor causing the disparate results was the use of a hard tissue marker (oxytetracycline) in the pilot study. It can be concluded that injections of PTH in doses that affect bone and dentin did not cause any changes in normal enamel formation.

Dentin formation in miniature pigs with special reference to indomethacin and orthodontic treatment

“…In combination, however, it was observed that the effect of one neutralized that of the other. The results of the present analysis support findings that general factors may influence dentin formation (15)(16).…”

“…The need to determine the effects of dental materials and drugs on the dentin mineralization rate is increasing with the increasing influx of new materials in dentistry. The impact of endocrinologic factors on dentin formation has previously been studied in the rat (15)(16)(17). But because ofthe rat's continuously growing incisors and high dentin mineralization rate (three times greater than the human dentin rate), the results cannot be directly compared with those obtained in the present study.…”

Parathyroid Hormone Secretion and Receptor Expression Determine the Age-Related Degree of Osteogenic Differentiation in Dental Pulp Stem Cells

“…In another similar study on mouse embryonic molars, it was again shown that PTH did not promote odontogenesis, but rather suppresses it [ 14 ]. Another study revealed that PTH does not affect the enamel formation of rat maxillary incisors [ 15 ]. Work on PTH and its effect on the embryonic tooth, molars, or maxillary incisors of rats did not consider the potential effect of PTH on mesenchymal stem cells.…”