Parental occupational exposure to organic solvents and anencephaly in Mexico

Aguilar-Garduño, Clemente; Lacasaña, Marina; Blanco-Muñoz, Julia; Borja-Aburto, Víctor Hugo; García, Ana M. García

doi:10.1136/oem.2008.044743

Cited by 20 publications

(18 citation statements)

References 40 publications

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“…However, this study assessed the association between congenital janitors, woodworkers, firemen, electrical workers, printers, and painters were reported to be at increased risk of having a child with a birth defect [20][21]. Exposures related to these occupations include solvents, wood and wood products, metals, and pesticides [22]. Using logistic regression, it was shown that the fathers occupationally exposed to pesticides (OR: 3.4, 95% CI: 1.9-5.9), solvents (OR: 5.6, 95% CI: 2.7-11.4), and welding fumes (OR: 2.98, 95% CI: 0.99-8.54) were significantly more likely to have congenitally malformed children.…”

Section: Discussionmentioning

confidence: 99%

“…The fathers and mothers of the cases, as well as the controls, were interviewed at the hospital premises by a trained physician and completed a questionnaire including questions about their personal history, past history of diseases, family history of congenital malformations, socioeconomic features, smoking, residence, and three-month periconceptional [15] occupational exposures to pesticides, solvents (including: glues, adhesives, polishes, thinners or turpentine), large population-based studies place the incidence of major malformations at about 2-3% of all live births [2][3][4][5][6]. Occupational and environmental agents are the suspected causes responsible for about 60% of birth defects with unknown etiology [7].…”

Section: Assessment Of Occupational and Environmental Exposurementioning

confidence: 99%

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Paternal occupational exposures and the risk of congenital malformations — A case-control study

El-Helaly¹,

Abdel-Elah²,

Haussein³

et al. 2011

International Journal of Occupational Medicine and Environmental Health

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Objectives: This study examined the association between certain paternal occupational exposures during the periconceptional period and the risk of congenital malformations. Materials and Methods: A case-control study was carried out from December 2009 to April 2010; on 242 congenital malformation cases and 270 controls. Paternal occupational exposure to certain workplace hazards was assessed by a detailed questionnaire to evaluate the occupational exposure for both fathers and mothers including pesticides, solvents, welding fumes, lead, working with video display terminals (VDTs) and computer monitors. In addition, the questionnaire assessed the presence of other risk factors such as consanguinity, smoking and history of any maternal diseases during the pregnancy with the child. Results: The results revealed that the odds of having a child with congenital malformation was higher (P < 0.01) if the father was occupationally exposed to pesticides (OR: 3.42, 95% CI: 1.97-5.92), solvents (OR: 5.63, 95% CI: 2.77-11.42), or welding fumes (OR: 2.98, 0.99-8.54) during the periconceptional period. However, consanguinity (OR: 1.91, 95% CI: 1.25-2.92) was a risk factor of developing congenital malformations among offspring. Conclusion: Control of workplace exposures and adherence to threshold limit values of those hazards should be adopted to minimize the risk of developing congenital malformations among offspring.

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Section: Discussionmentioning

confidence: 99%

Section: Assessment Of Occupational and Environmental Exposurementioning

confidence: 99%

Paternal occupational exposures and the risk of congenital malformations — A case-control study

El-Helaly¹,

Abdel-Elah²,

Haussein³

et al. 2011

International Journal of Occupational Medicine and Environmental Health

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“…Case-control studies also can associate a specific adverse outcome with paternal exposure 96. Such studies are very important in hypothesis generating for genetic damage to sperm, however, genetic damage is difficult to detect in human sperm 97.…”

Section: Assessments Of Male Reproductive Healthmentioning

confidence: 99%

Assessing the reproductive health of men with occupational exposures

Schrader

Marlow

2014

Asian J Androl

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The earliest report linking environmental (occupational) exposure to adverse human male reproductive effects dates back to1775 when an English physician, Percival Pott, reported a high incidence of scrotal cancer in chimney sweeps. This observation led to safety regulations in the form of bathing requirements for these workers. The fact that male-mediated reproductive harm in humans may be a result of toxicant exposures did not become firmly established until relatively recently, when Lancranjan studied lead-exposed workers in Romania in 1975, and later in 1977, when Whorton examined the effects of dibromochloropropane (DBCP) on male workers in California. Since these discoveries, several additional human reproductive toxicants have been identified through the convergence of laboratory and observational findings. Many research gaps remain, as the pool of potential human exposures with undetermined effects on male reproduction is vast. This review provides an overview of methods used to study the effects of exposures on male reproduction and their reproductive health, with a primary emphasis on the implementation and interpretation of human studies. Emphasis will be on occupational exposures, although much of the information is also useful in assessing environmental studies, occupational exposures are usually much higher and better defined.

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“…4 Epidemiologic studies have reported both increased risks--and, less frequently, no excess risk--of congenital malformations (mainly oral clefts, neural tube defects, and cardiac defects) among children of women working in occupations that include exposure to solvents. [5][6][7][8][9][10][11][12][13][14][15][16] The evidence nonetheless remains inconclusive because most of these studies did not identify the specific chemicals used. Moreover, because most studies of congenital malformations have collected exposure information only after the pregnancy outcome was known, recall bias cannot be ruled out.…”

mentioning

confidence: 99%

Exposure During Pregnancy to Glycol Ethers and Chlorinated Solvents and the Risk of Congenital Malformations

et al. 2012

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Parental occupational exposure to organic solvents and anencephaly in Mexico

Abstract: The results support the hypothesis that both maternal and paternal occupational exposure to organic solvents can increase the probability of having a child with anencephaly.

Cited by 20 publications

References 40 publications

Paternal occupational exposures and the risk of congenital malformations — A case-control study

Paternal occupational exposures and the risk of congenital malformations — A case-control study

Assessing the reproductive health of men with occupational exposures

Exposure During Pregnancy to Glycol Ethers and Chlorinated Solvents and the Risk of Congenital Malformations

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