Parental perception of educational, behavioural and general health problems in school‐age survivors of bacterial meningitis

Koomen, I.; Grobbee, Diederick E.; Jennekens‐Schinkel, A.; Roord, John J.; Furth, A. Marceline van

doi:10.1111/j.1651-2227.2003.tb00523.x

Cited by 35 publications

(28 citation statements)

References 25 publications

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“…Segundo Roine et al (2008) 6,8,26 , o que foi compatível com o presente estudo, já que pacientes com sequelas neurológicas apresentaram com maior frequência complicações neurológicas agudas. Sendo assim, destaca-se a importância dos fatores apontados por este estudo associados à maior ocorrência de complicações neurológicas agudas, uma vez que estes estão intimamente correlacionados à ocorrência de sequelas neurológicas.…”

Section: Discussionunclassified

“…Meningite bacteriana causada por S. pneumoniae foi selecionada como fator de risco para o desenvolvimento de complicações neurológicas agudas [razão de chances (odds ratio, OR) = 6,4; intervalo de confiança (IC) 1,[7][8][9][10][11][12][13][14][15][16][17][18][19][20][21][22][23][24]7], assim como neutropenia < 60% (p < 0,01). …”

Section: Métodosunclassified

“…Além disso, poucos estudos internacionais e nacionais avaliaram a associação entre as complicações neurológicas agudas e a apresentação clínica inicial, manejo e evolução dos pacientes, dando enfoque principalmente às sequelas neurológicas, considerando as complicações neurológicas agudas como sintomas ou sequelas neurológicas [6][7][8][9][10] .…”

Section: Introductionunclassified

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Childhood acute bacterial meningitis: risk factors for acute neurological complications and neurological sequelae

Antoniuk¹,

Hamdar²,

Ducci³

et al. 2011

J Pediatr (Rio J)

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Objective: To assess acute neurological complications and neurological sequelae of childhood acute bacterial meningitis in order to determine possible warning signs. Methods:This retrospective study evaluated children with acute bacterial meningitis (between 1 month and 14 years of age) admitted between 2003 and 2006. Results:Of the 44 patients studied, 17 (38.6%) had acute neurological complications. Seizure was the most frequent (31.8%) complication. Patients with acute neurological complications showed a higher frequency of lower neutrophil count (p = 0.03), seizure at admission (p < 0.01), and S. pneumoniae as the etiologic agent (p = 0.01). Risk factors for the development of acute neurological complications were S. pneumoniae (odds ratio [OR] = 6.4, confidence interval [CI] 1.7-24.7) and neutrophil count < 60% (p < 0.01). Of the 35 patients who were followed up, 14 had neurological sequelae (40%). Behavioral change (22.9%) was the most frequent sequela. Seizures at admission (OR = 5.6, CI 1.2-25.9), cerebrospinal fluid protein concentration > 200 mg/dL (p < 0.01), and cerebrospinal fluid glucose concentration/glycemia ratio (p < 0.01) were identified as risk variables for sequelae. Conclusion:Neutrophil count < 60%, seizure at admission, and S. pneumoniae as the etiologic agent were identified as warning signs for acute neurological complications, while protein levels, cerebrospinal fluid glucose concentration/glycemia ratio, and seizure at admission were seen as risk factors for neurological sequelae.J Pediatr (Rio J). 2011;87(6):535-40: Bacterial meningitis, neurological complications, neurological follow-up, pediatrics. ResumoObjetivo: Estudo retrospectivo que visa avaliar as complicações neurológicas agudas e sequelas neurológicas das meningites bacterianas agudas na infância, a fim de determinar possíveis sinais de alerta. Conclusão: Contagem de neutrófilos < 60%, crise convulsiva na admissão e S. pneumoniae como agente etiológico foram identificados como sinais de alerta para a ocorrência de complicação neurológica aguda, enquanto que proteinorraquia, menor relação glicorraquia/glicemia e crise convulsiva na internação foram observados como fatores de risco para a ocorrência de sequelas neurológicas.J Pediatr (Rio J). 2011;87(6):535-40

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Section: Discussionunclassified

Section: Métodosunclassified

Section: Introductionunclassified

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Childhood acute bacterial meningitis: risk factors for acute neurological complications and neurological sequelae

Antoniuk¹,

Hamdar²,

Ducci³

et al. 2011

J Pediatr (Rio J)

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“…The inclusion process of these children has been described in our report on parental perception of educational and behavioural problems (17). Briefly, the inclusion criteria were: birth date between January 1986 and December 1994, and recovery from meningitis caused by Neisseria meningitidis, Streptococcus pneumoniae, Streptococcus agalactiae, Escherichia coli or Listeria monocytogenes between January 1990 and December 1995.…”

Section: Study Populationmentioning

confidence: 99%

Prediction of academic and behavioural limitations in school‐age survivors of bacterial meningitis

Koomen

Grobbee²,

Roord

et al. 2004

Acta Paediatrica

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Aim: To develop a prediction rule to identify postmeningitic children at high risk of academic and behavioural limitations. Methods: 182 children (mean age 10 y; range 5-14) were selected from a cohort of 674 school-age survivors of bacterial meningitis. These children had neither meningitis with "complex onset", nor prior cognitive or behavioural problems, nor severe disease sequelae. On average, 7 y after the meningitis, they were evaluated using an "Academic Achievement Test", and their parents filled in the "Child Behaviour Checklist". By reviewing the medical records, potential risk factors for academic and/or behavioural limitations were collected. Independent predictors were identified using multivariate logistic regression analysis, leading to the formulation of a prediction rule. Results: The cumulative incidence of academic and/or behavioural limitations among children who survived bacterial meningitis without severe disease sequelae was 32%. The prediction rule was based on nine independent risk factors: gender, birthweight, educational level of the father, S. pneumoniae, cerebrospinal fluid leukocyte count, delay between admission and start of antibiotics, dexamethasone use, seizures treated with anticonvulsive therapy, and prolonged fever. When 10 was taken as a cut-off point for the risk score computed using this rule, 76% of the children with limitations could be identified, while 38% of the children in the cohort were selected as at risk for these limitations. Conclusion:With a prediction rule based on nine risk factors, postmeningitic children at high risk of developing academic and/or behavioural limitations could be identified. Additional research is required to further validate this prediction rule. In the future, a careful follow-up of high risk children may enhance early detection and treatment of these limitations.

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“…As many as 50% of survivors encounter neurological sequelae, such as hearing impairment, seizure disorders, and learning and behavioral problems (22,32,65).…”

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confidence: 99%

Chemotactic Factors in Cerebrospinal Fluid during Bacterial Meningitis

et al. 2006

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Parental perception of educational, behavioural and general health problems in school‐age survivors of bacterial meningitis

Cited by 35 publications

References 25 publications

Childhood acute bacterial meningitis: risk factors for acute neurological complications and neurological sequelae

Childhood acute bacterial meningitis: risk factors for acute neurological complications and neurological sequelae

Prediction of academic and behavioural limitations in school‐age survivors of bacterial meningitis

Chemotactic Factors in Cerebrospinal Fluid during Bacterial Meningitis

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