Parkinson’s disease and the risk of osteoporotic vertebral compression fracture: a nationwide population-based study

Lee, C. K.; Choi, Seok Keun; Shin, Dong Ah; Yi, Seong‐Tae; Kim, K. N.; Kim, I.; Ha, Yoon

doi:10.1007/s00198-018-4409-9

Cited by 17 publications

(15 citation statements)

References 33 publications

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“…There is accumulating evidence that the PD patients have an increased prevalence of osteoporosis and osteopenia [82][83][84], and PD is recognized as a cause of secondary osteoporosis [85]. In a study conducted in Korea, researchers found that 6542 (18.3%) of 35,663 PD patients experienced osteoporosis, and that fractures occurred most commonly within 6 months after PD onset and decreased after 3 years from PD diagnosis [86].…”

Section: The Relationship Between Vitamin D Level and Clinical Manifementioning

confidence: 99%

The relationships of vitamin D, vitamin D receptor gene polymorphisms, and vitamin D supplementation with Parkinson’s disease

Tan

et al. 2020

Transl Neurodegener

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In recent years, many studies have investigated the correlations between Parkinson's disease (PD) and vitamin D status, but the conclusion remains elusive. The present review focuses on the associations between PD and serum vitamin D levels by reviewing studies on the associations of PD with serum vitamin D levels and vitamin D receptor (VDR) gene polymorphisms from PubMed, Web of Science, Cochrane Library, and Embase databases. We found that PD patients have lower vitamin D levels than healthy controls and that the vitamin D concentrations are negatively correlated with PD risk and severity. Furthermore, higher vitamin D concentrations are linked to better cognitive function and mood in PD patients. Findings on the relationship between VDR gene polymorphisms and the risk of PD are inconsistent, but the FokI (C/T) polymorphism is significantly linked with PD. The occurrence of FokI (C/T) gene polymorphism may influence the risk, severity, and cognitive ability of PD patients, while also possibly influencing the effect of Vitamin D 3 supplementation in PD patients. In view of the neuroprotective effects of vitamin D and the close association between vitamin D and dopaminergic neurotransmission, interventional prospective studies on vitamin D supplementation in PD patients should be conducted in the future.

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Section: The Relationship Between Vitamin D Level and Clinical Manifementioning

confidence: 99%

The relationships of vitamin D, vitamin D receptor gene polymorphisms, and vitamin D supplementation with Parkinson’s disease

Tan

et al. 2020

Transl Neurodegener

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“…Although in a young healthy individual, a fall from standing height would not likely result in a fracture, in PD, reduced bone mineral density (150)(151)(152) and a higher frequency of falls increase fracture risk (43,(153)(154)(155)(156)(157)(158)(159) . Studies suggest that in PD, osteoporosis and fracture are twice as likely (150,160,161) , and in women, PD is the strongest single contributor to fracture risk (162) .…”

Section: Malnutrition Muscle and Bonementioning

confidence: 99%

Parkinson's disease: the nutrition perspective

et al. 2021

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Parkinson's disease (PD) is the second most common neurodegenerative disease after Alzheimer's disease and affects about 1% of the population over the age of 60 years in industrialised countries. The aim of this review is to examine nutrition in PD across three domains: dietary intake and the development of PD; whole body metabolism in PD and the effects of PD symptoms and treatment on nutritional status. In most cases, PD is believed to be caused by a combination of genetic and environmental factors and although there has been much research in the area, evidence suggests that poor dietary intake is not a risk factor for the development of PD. The evidence about body weight changes in both the prodromal and symptomatic phases of PD is inconclusive and is confounded by many factors. Malnutrition in PD has been documented as has sarcopaenia, although the prevalence of the latter remains uncertain due to a lack of consensus in the definition of sarcopaenia. PD symptoms, including those which are gastrointestinal and non-gastrointestinal, are known to adversely affect nutritional status. Similarly, PD treatments can cause nausea, vomiting and constipation, all of which can adversely affect nutritional status. Given that the prevalence of PD will increase as the population ages, it is important to understand the interplay between PD, comorbidities and nutritional status. Further research may contribute to the development of interventional strategies to improve symptoms, augment care and importantly, enhance the quality of life for patients living with this complex neurodegenerative disease.

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“…A meta-analysis showed an increased risk of fracture of 2 to 3 times in PD patients compared to controls 9 . A nationwide population-based study found a significantly increased risk of osteoporosis (hazard ratio 1.32) and surgery for OVC (hazard ratio 2.69) in PD patients compared to non-PD subjects 10 . Weight loss and sarcopenia are common in PD patients and correlate with greater motor changes, a higher rate of fall, and disease progression 11 .…”

Section: Discussionmentioning

confidence: 98%

Clinical and imaging features of surgically treated low lumbar osteoporotic vertebral collapse in patients with Parkinson’s disease

Nakajima

Kubota

Watanabe

et al. 2021

Sci Rep

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Osteoporosis and Parkinson’s disease (PD) are age-related diseases, and surgery for osteoporotic vertebral collapse (OVC) in PD patients become more common. OVC commonly affects the thoracolumbar spine, but low lumbar OVC is frequent in patients with lower bone mineral density (BMD). The aim of this study was to identify differences in clinical and imaging features of low lumbar OVC with or without PD and to discuss the appropriate treatment. The subjects were 43 patients with low lumbar OVC below L3 who were treated surgically, including 11 patients with PD. The main clinical symptoms were radicular pain in non-PD cases and a cauda equina sign in PD cases. Rapid progression and destructive changes of OVC were seen in patients with PD. The morphological features of OVC were flat-type in non-PD cases with old compression fracture, and destruction-type in PD cases without old compression fracture. Progression of PD was associated with decreased lumbar lordosis, lower lumbar BMD, and severe sarcopenia. High postoperative complication rates were associated with vertebral fragility and longer fusion surgery. Progression of postural instability as a natural course of PD may lead to mechanical stress and instrumentation failure. Invasive long-fusion surgery should be avoided for single low lumbar OVC.

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Parkinson’s disease and the risk of osteoporotic vertebral compression fracture: a nationwide population-based study

Abstract: Patients with PD had significantly increased risk of osteoporosis and OVCF. Surgical treatment for OVCF in PD patients was associated with a better prognosis than conservative treatment.

Cited by 17 publications

References 33 publications

The relationships of vitamin D, vitamin D receptor gene polymorphisms, and vitamin D supplementation with Parkinson’s disease

The relationships of vitamin D, vitamin D receptor gene polymorphisms, and vitamin D supplementation with Parkinson’s disease

Parkinson's disease: the nutrition perspective

Clinical and imaging features of surgically treated low lumbar osteoporotic vertebral collapse in patients with Parkinson’s disease

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