Parotid Gland Function after Radiotherapy: The Combined Michigan and Utrecht Experience

Effect of Cisplatin on Parotid Gland Function in Concomitant Radiochemotherapy

“…Not only because of the high number of patients (n = 306), the recently published study of Dijkema et al (28) needs especially to be acknowledged. In that study, the parameter TD 50 was calculated as 39.8 Gy at 12 months post-treatment, close to the data of the XRT group 6 months post-treatment (TD 50 = 39.6 Gy).…”

Technique for comprehensive head and neck irradiation using 3-dimensional conformal proton therapy

“…Existing parotid gland normal tissue complication probability curves suggest that these reductions could further reduce the risk of late xerostomia. 20 Although predicted by available models, we regard these potential differences in toxicity as hypothetical. Further evaluation of proton therapy to assess for potential reductions in clinical toxicities is warranted.…”

“…Summary statistics for each OAR were recorded, including the mean dose and the volume of the OAR. Mean dose was selected as it is the dosimetric parameter that most consistently correlated with late head and neck toxicity outcomes including parotid dysfunction and dysphagia [18][19][20][21] as well as acute mucositis and dysphagia. 22 An approximation of the integral dose to OARs was calculated as the mean dose in Gy multiplied by the volume in cm 3 , assuming a uniform density of OARs.…”

Radiation-Induced Damage to Microstructure of Parotid Gland: Evaluation Using High-Resolution Magnetic Resonance Imaging

“…The present results showed that the morphologic changes of the parotid gland are already present during the RT course, even when an only relatively small dose has been delivered to the parotid gland. Data regarding the doses and irradiated volumes that permit preservation of salivary function have been estimated (25)(26)(27). The reported mean dose to the parotid gland to preserve 25-50% of salivary flow at 1 year after RT is 20-26 Gy (25,27,28), and the dose leading to complications in 50% of cases at 1 year after RT is 28.4-39.5 Gy (25,26,29).…”