PART 3. GENERAL ARTICLELong-Term Follow-Up Study of Bioactive Bone Cement for Repairing a Segmental Defect in a Canine Femur

Fujibayashi, Shunsuke; Senaha, Y.; Yoshihara, Satoshi; Tamura, Jiro; Nakamura, Takashi

doi:10.1615/jlongtermeffmedimplants.v11.i12.90

Cited by 3 publications

(2 citation statements)

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“…Correct initial diagnosis is key to optimal management of Brodie's abscess, and this involves rapid surgical treatment with aggressive debridement and defect repair in order to avoid septic complications (local and systemic) and traumatic complications, such as pathological fractures due to poor resistance of the remaining bone mass surrounding the abscess. Defect reconstruction can be achieved by using both bone graft [9] and bone inducing cement [10][11][12]. In this particular case, the second option was chosen because of the large dimensions of the abscess cavity.…”

Section: Discussionmentioning

confidence: 99%

Rare Intercondylar Distal Femoral Brodie’s Abscess in a 21-Year-Old Man Who Refused Medical Care for Three Years after Initial Symptoms

et al. 2021

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Brodie’s abscess is a rare form of sub-acute osteomyelitis that implies the collection of pus inside bone tissue. The present paper presents an extremely rare case of Brodie’s abscess located in the distal femur in a young male patient who refused medical care for three years and presented directly with spontaneous fistula and septic complications. Laboratory tests also suggested chronic septic alterations. Complex imaging investigations including X-ray (RX), computer tomography (CT) and Magnetic Resonance imaging (MRI) confirmed the diagnosis with characteristic aspects, such as the penumbra sign on the T1 weighted MRI image. Management included aggressive debridement, defect reconstruction, and long-term specific antibiotics according to culture harvested intra-operatively. Evolution was positive with inflammatory blood tests returning to physiological values within four weeks and patient full recovery within six months, without any physical deficits. The novelty aspect found in this case presentation is represented by the long-term natural evolution of this pathology, and the fact that even in these conditions, the Brodie’s abscess did not evolve into a ‘malignant’ septic condition, but remained rather benign until the spontaneous fistula prompted the patient to seek medical care.

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Section: Discussionmentioning

confidence: 99%

Rare Intercondylar Distal Femoral Brodie’s Abscess in a 21-Year-Old Man Who Refused Medical Care for Three Years after Initial Symptoms

et al. 2021

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“…108 Numerous attempts have been made to improve CPCs via such methods as (1) optimization of osteoconduction through the creation of pores 109 (Fig. 6), (2) improvement of the strength of the cement through the incorporation of various fillers, 110,111 and 3applications for delivery of therapeutic molecules such as antibiotics, anti-cancer drugs, and anti-inflammatories. 112,113 The few CPCs commercially available, Norian Skeletal Repair System Ò (Synthes, Inc., West Chester, PA), BoneSource Ò (Stryker Ò , Kalamazoo, MI), and a-Bone Substitute Material Ò (Etex Corporation, Cambridge, MA), are only recommended for nonweight-bearing applications.…”

Section: Calcium Phosphate Cementmentioning

confidence: 99%

Bone Cements and Their Potential Use in a Mandibular Endoprosthesis

Lye

Tideman

Merkx

et al. 2009

Tissue Engineering Part B: Reviews

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Bone cement was first used in the 1950s. Since then many modifications have been made and alternatives developed to the original polymethylmethacrylate (PMMA) cement. In view of the use of bone cement in a novel mandibular endoprosthetic system, we performed a review of the current literature on this material. Different cements are described and their potential use in a mandibular endoprosthetic system discussed. The PMMA-based cements are currently the most suitable choice. Plain PMMA has the longest track record and is the default choice for the initial development phase of this system. If there is a significant risk of infection, then an antibiotic-loaded PMMA cement can be selected. However, modified PMMA cements, composite resin cements, osteoinductive calcium phosphate compounds, and cementless fixation are options that offer advantages over PMMA cements, and further research should be conducted to study their suitability.

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Bone regeneration in long-bone defects: tissue compartmentalisation? In vivo study on bone defects in sheep

Klaue

Knothe

Anton³

et al. 2009

Injury

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PART 3. GENERAL ARTICLELong-Term Follow-Up Study of Bioactive Bone Cement for Repairing a Segmental Defect in a Canine Femur

Cited by 3 publications

References 0 publications

Rare Intercondylar Distal Femoral Brodie’s Abscess in a 21-Year-Old Man Who Refused Medical Care for Three Years after Initial Symptoms

Rare Intercondylar Distal Femoral Brodie’s Abscess in a 21-Year-Old Man Who Refused Medical Care for Three Years after Initial Symptoms

Bone Cements and Their Potential Use in a Mandibular Endoprosthesis

Bone regeneration in long-bone defects: tissue compartmentalisation? In vivo study on bone defects in sheep

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