Part XVI - Stereospecific ligands and their complexes. Synthesis, characterization and in vitro antiproliferative activity of new platinum(IV) complexes with some O,O'-dialkyl esters of (S,S)-ethylenediamine-N,N'-di-2-propanoic acid against breast cancer

Abstract

<p>Synthesis of four new platinum(IV) complexes <strong>C</strong><strong>1–C4</strong>, with bidentate <em>N,N'</em>-ligand precursors, <em>O,O'</em>-dialkyl esters <strong>L1-L4</strong> (alkyl = ethyl, propyl, butyl and pentyl), of (<em>S,S</em>)-ethylenediamine-<em>N,N'</em>-di-2-propanoic acid, H<sub>2</sub>-<em>S,S-</em>eddp were reported. The reported platinum(IV) complexes characterized by elemental analysis and their structures were discussed on the bases of their infrared, <sup>1</sup>H and <sup>13</sup>C NMR spectroscopy. The cytotoxic activity was determined on tumor cell lines: human breast carcinoma MDA-MB-231, human colon carcinoma HCT-116 and SW-480, using MTT test. It showed the greater the size of the investigated complex or ligand the greater the cytotoxicity.</p>

Novel seleno-hydantoin palladium(II) complex – antimigratory, cytotoxic and prooxidative potential on human colon HCT-116 and breast MDA-MB-231 cancer cells

“…Modern medicine is still largely focused on the application of platinum-containing (Kalinowska-Lis et al 2008;Jevtic et al 2014) and palladium-containing (Sabo et al 2004;Matovic et al 2013) chemotherapeutic cytotoxic agents. On the other hand, selenium has proven to be an important supplement for the suppression of the side effects of chemotherapy (Schroeder et al 2004;Markovic et al 2011;Brodin et al 2015;Mut-Salud et al 2016).…”

Effects of Teucrium spp.: Extracts on migratory potential and redox status of human colon SW-480 and breast MDA-MB-231 cancer cells

“…The processes of formation and spread of tumors in distant locations through the human body (metastases) are studied intensively. In many preclinical studies various chemically synthesized substances are used (JEVTIC et al, 2014;KALINOWSKA-LIS et al, 2008;PETROVIC et al, 2015;SABO et al, 2004), as well as extracts isolated from plant material (Ravelo et al, 2004). Many of these studies are based on toxicity testings, with a focus on in situ selectivity towards a certain type of tumor.…”