Partial gastrectomy and mineral metabolism: effects on gastrin-calcitonin release

Filipponi, P; Gregorio, F. Di; Cristallini, S.; Mannarelli, C.; Blass, Andrea; Scarponi, Anna Maria; Vespasiani, G

doi:10.1016/0169-6009(90)90059-o

Cited by 39 publications

(21 citation statements)

References 24 publications

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“…In addition, there was no difference in BMD and osteoporosis rate among patients undergoing Billroth Ⅰ, Billroth Ⅱ and Rouxen-Y reconstr uction. Although some studies have shown that Billroth Ⅱ reconstruction patients have lower BMD compared to those undergoing Billroth Ⅰ reconstruction [15,16] , our results showed no difference in osteoporosis rate in relation to surgical reconstruction type, as in previous studies [12,17] . These results indicate that gastrectomy itself affects BMD rather than the reconstr uction method.…”

Section: Discussionsupporting

confidence: 63%

“…Following gastric resection, reduced cortical and trabecular bone mass have been reported, however, the mechanism remains unclear [5,6] . The american Gastroenterological Association (AGA) has recommended dual-energy X-ray absorptiometry (DXA) in patients who are alive at least 10 years after gastrectomy [6] , based on many reports of post-gastrectomy bone disease [7][8][9][10][11][12][13][14][15][16][17][18][19][20] . Most studies have dealt with patients with peptic ulcer disease, and those focusing on gastric cancer patients are rare.…”

Section: Introductionmentioning

confidence: 99%

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High prevalence of osteoporosis in patients with gastric adenocarcinoma following gastrectomy

Lim¹,

Kim²,

Bang³

et al. 2007

WJG

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AIM:To evaluate the prevalence and predictive factors of osteoporosis in patients with gastric adenocarcinoma after gastrectomy. METHODS:The study included 133 patients diagnosed with gastric adenocarcinoma but who did not undergo prior diagnostic work-up for osteoporosis. Bone mineral density (BMD) was measured by dual-energy X-ray absorptiometry (DXA) and vertebral deformity was assessed by plain X-rays. We evaluated the effects of age, sex, body mass index (BMI), anemia, back pain, vertebral deformity, tumor staging, reconstruction type, and past medical history to determine predictive factors of osteoporosis in these patients. RESULTS:The prevalence of osteoporosis in the lumbar spine was 38.3% (male, 28.9%; female, 54.0%), and 15.0% in the femoral neck (male, 10.8%; female, 22.0%). The vertebral deformity rate was 46.6% (male, 43.4%; female, 52.0%). Age, BMI and hemoglobin correlated with BMD (P < 0.01). In males, anemia and age > 64 years were independent predictive factors of osteoporosis in multivariate analysis. In females, back pain was an independent factor for osteoporosis. CONCLUSION:The results of this study revealed that prevalence of osteoporosis and vertebral bone deformity rate were high in gastric cancer patients, regardless of post-gastrectomy duration and operation type. Early diagnosis and a proper management plan must be established in these patients.

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Section: Discussionsupporting

confidence: 63%

Section: Introductionmentioning

confidence: 99%

High prevalence of osteoporosis in patients with gastric adenocarcinoma following gastrectomy

Lim¹,

Kim²,

Bang³

et al. 2007

WJG

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“…It is well known that gastrectomy, including the removal of the antrum, where gastrinproducing G-cells are located, leads to a significant reduction in bone density and alterations in calcium metabolism (24,25). In fact, it has been shown in gastrectomized patients that in response to a meal, increases in calcitonin levels were significantly smaller than in control groups, most likely based on impaired gastrin secretion (23). Animal models have confirmed the importance of gastrin for calcium and bone homeostasis; in rats, antrectomy and total gastrectomy, both resulting in hypogastrinemia, lead to osteopenia and reduction in bone mineral content (26,27).…”

Section: Immunohistochemistrymentioning

confidence: 99%

“…Thirty years ago, it was shown for the first time that both hormones induce calcitonin secretion (20,21). The physiological and pathophysiological relevance of these early findings has been discussed controversially (22,23). It is well known that gastrectomy, including the removal of the antrum, where gastrinproducing G-cells are located, leads to a significant reduction in bone density and alterations in calcium metabolism (24,25).…”

Section: Immunohistochemistrymentioning

confidence: 99%

Expression of the cholecystokinin 2-receptor in normal human thyroid gland and medullary thyroid carcinoma

Bläker

Weerth

Tometten

et al. 2002

European Journal of Endocrinology

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Objective: The cholecystokinin 2 -receptor (CCK 2 R) promotes secretion and cell growth induced by its ligands cholecystokinin (CCK) and gastrin. The receptor has recently been shown to be expressed in human medullary thyroid carcinomas (MTCs). The objective of this study was to analyze CCK 2 R expression in MTC samples of different tumor stages as well as in non-malignant thyroid tissues. Design and Methods: Using RT-PCR we investigated 19 MTC samples and TT-cells (a human MTC cell line), as well as samples of normal thyroid. In addition, we performed immunohistochemistry using calcitonin-and CCK 2 R-specific antibodies on MTCs and samples of C-cell hyperplasia. Results: We demonstrate for the first time that CCK 2 R is expressed not only in MTCs but in all samples of normal thyroid tissue. Using immunohistochemistry the receptor could be localized on calcitoninsecreting C-cells. The highest incidence of CCK 2 R expression in MTCs was observed in early-tumor stages, whereas CCK 2 R could not be detected in advanced or metastasized tumors. Conclusions: The expression of CCK 2 R in C-cells suggests a physiological function for gastrin and/or CCK in the regulation of calcitonin release, presumably related to bone and calcium metabolism. Moreover, these ligands might act as growth factors in MTCs. Efforts in the development of CCK 2 R scintigraphy for the detection of MTC lesions might have to consider a lower incidence of the receptor in advanced tumor stages.

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“…Calcium malnutrition and calcium malabsorption are considered to be a risk of osteoporosis in both gender, apart from hormonal imbalances (Peterlik et al, 2013). Lower serum levels of vitamin D and calcium result in higher PTH levels, increasing the rate of bone loss (Filipponi et al, 1990). Previous studies indicated that a nutritional calcium deficit was popular in different population groups, however, level of calcium intake in male population was not so lower than female population (Peterlik et al, 2009).…”

mentioning

confidence: 99%

Prevalence of and Factors Associated with Osteoporosis among Korean Cancer Survivors: A Cross-Sectional Analysis of the Fourth and Fifth Korea National Health and Nutrition Examination Surveys

Choi

Park

et al. 2013

Asian Pacific Journal of Cancer Prevention

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Background: Identifying and managing osteoporosis among cancer survivors is an important issue, yet little is known about the bone health of cancer survivors in Korea. This study was designed to measure the prevalence of osteoporosis and to assess related factors among Korean cancer survivors. Materials and Methods: This study was designed as a cross-sectional analysis. Data were obtained from dual energy X-ray absorptiometry measurement of the lumbar vertebrae and femoral neck, and from standardized questionnaires among 556 cancer survivors and 17,623 non-cancer controls who participated in the Fourth and Fifth Korea National Health and Nutrition Examination Surveys (2008-2011). We calculated adjusted proportions of osteoporosis in non-cancer controls vs. cancer survivors, and we performed multivariate logistic regression analysis. Results: The prevalence of osteoporosis among cancer survivors was significant higher than that of the non-cancer controls after adjusting for related factors. Furthermore, osteoporosis among cancer survivors was higher in elderly subjects (60-69 years : adjusted odds ratio (aOR) 3.04, 95% CI : 1.16-8.00, ≥70 years : aOR 6.60, 95% CI 2.20-19.79), in female cancer survivors (aOR: 7.03, 95% CI: 1.88-26.28), and in a group with lower monthly income (aOR: 3.38, 95% CI: 1.31-8.71). In male cancer survivors, underweight and lower calcium intake were risk factors. Conclusions: These data suggest that the osteoporosis among cancer survivors varies according to non-oncologic and oncologic factors. Effective screening should be applied, and a sufficient and comprehensive management should be matched to individual cancer survivors early after cancer treatment.

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Partial gastrectomy and mineral metabolism: effects on gastrin-calcitonin release

Cited by 39 publications

References 24 publications

High prevalence of osteoporosis in patients with gastric adenocarcinoma following gastrectomy

High prevalence of osteoporosis in patients with gastric adenocarcinoma following gastrectomy

Expression of the cholecystokinin 2-receptor in normal human thyroid gland and medullary thyroid carcinoma

Prevalence of and Factors Associated with Osteoporosis among Korean Cancer Survivors: A Cross-Sectional Analysis of the Fourth and Fifth Korea National Health and Nutrition Examination Surveys

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