Partial molar volumbes of gases at infinite dilution in water at 298.15 K

Moore, Joseph Curtis; Battino, Rubin; Rettich, Timothy R.; Handa, Y. P.; Wilhelm, Emmerich

doi:10.1021/je00027a005

Cited by 147 publications

(100 citation statements)

References 9 publications

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“…An additional transport component identified in the fringe spacing dependence is likewise too fast to be due to translation diffusion of the protein. The fringe spacing dependence was used to determine a diffusion constant (28) of 1.8 Ϯ 0.2 ϫ 10 Ϫ5 cm 2 ͞s at 20°C, which is in reasonable agreement with that expected for CO and has a positive volume contribution also consistent with CO solvation (29). On the basis of the magnitude of the observed diffusion constant, this component can be definitely assigned to solvated CO and is measured to be Ϸ35% of the initial signal amplitude.…”

Section: Resultssupporting

confidence: 69%

Diffractive optics-based heterodyne-detected four-wave mixing signals of protein motion: From “protein quakes” to ligand escape for myoglobin

Dadusc

Ogilvie

Schulenberg

et al. 2001

Proc. Natl. Acad. Sci. U.S.A.

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Ligand transport through myoglobin (Mb) has been observed by using optically heterodyne-detected transient grating spectroscopy. Experimental implementation using diffractive optics has provided unprecedented sensitivity for the study of protein motions by enabling the passive phase locking of the four beams that constitute the experiment, and an unambiguous separation of the Real and Imaginary parts of the signal. Ligand photodissociation of carboxymyoglobin (MbCO) induces a sequence of events involving the relaxation of the protein structure to accommodate ligand escape. These motions show up in the Real part of the signal. The ligand (CO) transport process involves an initial, small amplitude, change in volume, reflecting the transit time of the ligand through the protein, followed by a significantly larger volume change with ligand escape to the surrounding water. The latter process is well described by a single exponential process of 725 ؎ 15 ns at room temperature. The overall dynamics provide a distinctive signature that can be understood in the context of segmental protein fluctuations that aid ligand escape via a few specific cavities, and they suggest the existence of discrete escape pathways.

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Section: Resultssupporting

confidence: 69%

Diffractive optics-based heterodyne-detected four-wave mixing signals of protein motion: From “protein quakes” to ligand escape for myoglobin

Dadusc

Ogilvie

Schulenberg

et al. 2001

Proc. Natl. Acad. Sci. U.S.A.

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show abstract

“…8 Barbero et al (28) 0.1 33. 9 Moore et al (27) maximum compressibility of water (T=667 K at p=28 MPa, and T=693 K at p=35 MPa); above these temperatures, the uncertainty decreased to about 2·10 −2 ·V f at T=705 K.…”

Section: Resultsmentioning

confidence: 96%

Volumes of aqueous solutions of CH4, CO2, H2S and NH3at temperatures from 298.15 K to 705 K and pressures to 35 MPa

1996

The Journal of Chemical Thermodynamics

143

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“…The slightly smaller volume observed for oxetane is probably attributable to its hydrogen-bonding capacity. [74] …”

Section: Analogy Of Oxetanes To Gem-dimethyl Groupsmentioning

confidence: 99%

Oxetanes as Versatile Elements in Drug Discovery and Synthesis

et al. 2010

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Sizable resources, both financial and human, are invested each year in the development of new pharmaceutical agents. However, despite improved techniques, the new compounds often encounter difficulties in satisfying and overcoming the numerous physicochemical and many pharmacological constraints and hurdles. Oxetanes have been shown to improve key properties when grafted onto molecular scaffolds. Of particular interest are oxetanes that are substituted only in the 3-position, since such units remain achiral and their introduction into a molecular scaffold does not create a new stereocenter. This Minireview gives an overview of the recent advances made in the preparation and use of 3-substituted oxetanes. It also includes a discussion of the site-dependent modifications of various physicochemical and biochemical properties that result from the incorporation of the oxetane unit in molecular architectures.

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Partial molar volumbes of gases at infinite dilution in water at 298.15 K

Cited by 147 publications

References 9 publications

Diffractive optics-based heterodyne-detected four-wave mixing signals of protein motion: From “protein quakes” to ligand escape for myoglobin

Diffractive optics-based heterodyne-detected four-wave mixing signals of protein motion: From “protein quakes” to ligand escape for myoglobin

Volumes of aqueous solutions of CH4, CO2, H2S and NH3at temperatures from 298.15 K to 705 K and pressures to 35 MPa

Oxetanes as Versatile Elements in Drug Discovery and Synthesis

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