Particle Coating in Fluidized Beds

Foroughi-Dahr, Mohammad; Mostoufi, Navid; Sotudeh‐Gharebagh, Rahmat; Chaouki, Jamal

doi:10.1016/b978-0-12-409547-2.12206-1

Cited by 18 publications

(9 citation statements)

References 83 publications

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“…However, the size and shape of the glass microspheres were markedly different from those of two-dimensional substrates, thus the traditional making techniques for planar membranes were inapplicable to control the grafting uniformity and film thickness. The bottom-spray fluidized bed technology has been widely used to obtain homogeneous and dense films on particle surfaces [ 26 , 27 , 28 ]. Therefore, a self-made bottom-spray fluidized bed reactor [ 29 ] (see Figure 1 C,D) was introduced in this study, by taking advantage of distribution uniformity and easy control to achieve a uniform coating and thickness accumulation on the glass microspheres.…”

Section: Resultsmentioning

confidence: 99%

Controlled Release of Insulin Based on Temperature and Glucose Dual Responsive Biomicrocapsules

Fan

Lei

et al. 2022

Molecules

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The treatment of diabetes lies in developing novel functional carriers, which are expected to have the unique capability of monitoring blood glucose levels continuously and dispensing insulin correctly and timely. Hence, this study is proposing to create a smart self-regulated insulin delivery system according to changes in glucose concentration. Temperature and glucose dual responsive copolymer microcapsules bearing N-isopropylacrylamide and 3-acrylamidophenylboronic acid as main components were developed by bottom-spray coating technology and template method. The insulinoma β-TC6 cells were trapped in the copolymer microcapsules by use of temperature sensitivity, and then growth, proliferation, and glucose-responsive insulin secretion of microencapsulated cells were successively monitored. The copolymer microcapsules showed favorable structural stability and good biocompatibility against β-TC6 cells. Compared with free cells, the biomicrocapsules presented a more effective and safer glucose-dependent insulin release behavior. The bioactivity of secreted and released insulin did not differ between free and encapsulated β-TC6 cells. The results demonstrated that the copolymer microcapsules had a positive effect on real-time sensing of glucose and precise controlled release of insulin. The intelligent drug delivery system is supposed to mimic insulin secretion in a physiological manner, and further provide new perspectives and technical support for the development of artificial pancreas.

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Section: Resultsmentioning

confidence: 99%

Controlled Release of Insulin Based on Temperature and Glucose Dual Responsive Biomicrocapsules

Fan

Lei

et al. 2022

Molecules

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“…These data suggested that polyethylene glycol 400, which was used as a plasticizer, was able to reduce the glass transition temperature of methylcellulose and promoted its plasticity and flexibility. This temperature is one of the most vital properties that determine chain mobility of polymer in which the polymer transforms from hard, glassy material to soft, rubbery material with accepted tensile strength and percentage elongation [ 67 ].…”

Section: Resultsmentioning

confidence: 99%

Application of Box-Behnken Design in the Preparation, Optimization, and In-Vivo Pharmacokinetic Evaluation of Oral Tadalafil-Loaded Niosomal Film

et al. 2023

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Benign prostatic hyperplasia (BPH) affects about 90% of men whose ages are over 65. Tadalafil, a selective PDE-5 inhibitor, was approved by FDA for BPH, however, its poor aqueous solubility and bioavailability are considered major drawbacks. This work intended to develop and evaluate oral fast dissolving film containing tadalafil-loaded niosomes for those who cannot receive the oral dosage form. Niosomes were statistically optimized by Box-Behnken experimental design and loaded into a polymeric oral film. Niosomes were assessed for their vesicular size, uniformity, and zeta potential. The thickness, content uniformity, folding endurance, tensile strength, disintegration time, and surface morphology were evaluated for the prepared polymeric film. The optimized niosomes revealed high entrapment efficiency (99.78 ± 2.132%) and the film was smooth with good flexibility and convenient thickness (110 ± 10 µm). A fast release of tadalafil was achieved within 5 min significantly faster than the niosomes-free drug film. The in-vivo bioavailability in rats established that the optimized niosomal film enhanced tadalafil systemic absorption, with higher peak concentration (Cmax = 0.63 ± 0.03 µg/mL), shorter Tmax value (0.66-fold), and relative bioavailability of 118.4% compared to the marketed tablet. These results propose that the oral film of tadalafil-loaded niosomes is a suitable therapeutic application that can be passed with ease to geriatric patients who suffer from BPH.

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“…Plasticizers are low-molecular-weight chemicals that contribute to the plasticity and flexibility of the polymeric material by lowering their glass transition temperature. 53 Plasticizers also facilitate the ionic mobility across the polymer electrolytes, which translates in higher ionic conductivity. 54 Multiple plasticizers have been employed to develop polymer electrolytes, including dimethyl carbonate, diocthyl adipate, dibutyl phthalate, propylene carbonate, and glycerol, among others.…”

Section: Approaches For a Better Performancementioning

confidence: 99%

Section: Approaches For a Better Performancementioning

confidence: 99%

Bacterial-Polymer-Based Electrolytes: Recent Progress and Applications

Torres

De-la-Torre

Gonzales

et al. 2020

ACS Appl. Energy Mater.

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Bacteria can naturally synthesize a wide range of biopolymers that have appealing material properties for numerous applications. In the past decade, the development of green electronics based on bacterial polymers has gained major attention. Polymer electrolytes are key components in electrochemical devices owing to their mechanical properties, thermal stability, and ionic conductivity. The present review focuses on the recent progress of bacterial-polymer-based electrolytes and their applications in electrochemical energy conversion and storage. First, we described the ion transfer mechanism of polymer electrolytes and the multiple approaches for improving ionic conductivity and mechanical properties. Then, we summarized the composition, performance, and approaches applied for the development of multiple bacterial polymer electrolytes, namely, polysaccharides, polyanhydrides, and polyesters. Lastly, the practical applications of bacterial-polymer-based electrolytes in electrochemical energy storage and conversion, namely, fuel cells, batteries, supercapacitors, and other electrochemicals, are reviewed. Bacterial polymer electrolytes are presented as a fruitful, eco-friendly, and high-performance alternative for traditional solid polymer electrolytes.

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Particle Coating in Fluidized Beds

Cited by 18 publications

References 83 publications

Controlled Release of Insulin Based on Temperature and Glucose Dual Responsive Biomicrocapsules

Controlled Release of Insulin Based on Temperature and Glucose Dual Responsive Biomicrocapsules

Application of Box-Behnken Design in the Preparation, Optimization, and In-Vivo Pharmacokinetic Evaluation of Oral Tadalafil-Loaded Niosomal Film

Bacterial-Polymer-Based Electrolytes: Recent Progress and Applications

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