In this paper, was presented the numerical simulation of air pollution by particles with different sizes from the Ekibastuz State district power plant-1 (Ekibastuz SDPP-1), which is located on the northern side of Zhyngyldy Lakeshore, the Republic of Kazakhstan in real scales using the three-dimensional mathematical model. It was found that the deterioration of the environment is due to the release of a large amount of SOx, NOx and the volatile particles of Suspended Particulate Matter and Respirable Suspended Particles matter (SPM and RSPM), which cause human and animal diseases. For the adequacy of the mathematical model, the test problem was solved. The experimental data were used to evaluate the applicability of the mathematical model and the numerical algorithm for the test problem. The obtained numerical simulation results are in good agreement with the numerical results of other authors and the experimental data. In addition, to select the optimal turbulent model, the obtained simulation results for different turbulent models were compared with experimental data. Moreover also the boundary conditions for turbulent models (k − ε, k − ω), boundary conditions for turbulent kinetic energy were chosen to match the experimental data.