Particulate matter and hospital admission due to arterial hypertension in a medium-sized Brazilian city

Nascimento, Luiz Fernando Costa; Francisco, Juliana Batrov

doi:10.1590/0102-311x00127612

Cited by 10 publications

(9 citation statements)

References 20 publications

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“…A recent study by (Liu et al 2013) found that PM mediates insulin resistance by regulating visceral adipose tissue inflammation, hepatic lipid metabolism, and glucose utilization in skeletal muscle. An epidemiological study by (Nascimento and Francisco 2013) found that in a city in Brazil as PM exposure increased so did hospitalization due to hypertension. A 10µg/m 3 increase in concentration of particulate matter was associated with a 13% increase in risk of hospitalization.…”

Section: Discussionmentioning

confidence: 99%

Particulate Matter From Saudi Arabia Induces Genes Involved in Inflammation, Metabolic Syndrome and Atherosclerosis

Brocato

Sun

Shamy

et al. 2014

Journal of Toxicology and Environmental Health, Part A

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Airborne particulate matter (PM) exposure is a major environmental health concern and is linked to metabolic disorders, such as cardiovascular diseases (CVD) and diabetes, which are on the rise in the Kingdom of Saudi Arabia. This study investigated changes in mouse lung gene expression produced by administration of PM10 collected from Jeddah, Saudi Arabia. FVB/N mice were exposed to 100 µg PM10 or water by aspiration and euthanized 24 hr later. The bronchoalveolar lavage fluid (BALF) was collected and analyzed for neutrophil concentration and TNF-α and IL-6 levels. RNA was extracted from the lungs and whole transcript was analyzed using Affymetrix Mouse Gene 1.0 ST Array. Mice exposed to PM10 displayed an increase in neutrophil concentration and elevated TNF-α and IL-6 levels. Gene expression analysis revealed that mice exposed to PM10 displayed 202 genes that were significantly up-regulated and 40 genes that were significantly down-regulated. PM10 induced genes involved in inflammation, cholesterol and lipid metabolism, as well as atherosclerosis. This is the first study to demonstrate that Saudi Arabia PM10 increases in vivo expression of genes located in pathways associated with diseases involving metabolic syndrome and atherosclerosis.

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Section: Discussionmentioning

confidence: 99%

Particulate Matter From Saudi Arabia Induces Genes Involved in Inflammation, Metabolic Syndrome and Atherosclerosis

Brocato

Sun

Shamy

et al. 2014

Journal of Toxicology and Environmental Health, Part A

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“…A study in Canada found that per increase in 3-day lag PM 2.5 concentration by 6.2 μg/m 3 the estimated OR for hospital admissions for hypertension was 1.07 (95% CI: 1.01, 1.11) [36]. Similarly, a study in Brazil reported a positive association of ambient PM 2.5 with hospital admissions for hypertension: per 10 μg/m 3 increase in PM 2.5 lags 0-4, the estimated relative risks (RR) were 1.018-1.021 (p < 0.05) [41]. A study in China also reported a very comparable estimate: p OR 1.084 (95% CI: 1.028, 1.139) per 10 μg/m 3 increase in short-term PM 2.5 [27] Some studies report different results by subgroup or by exposure measurement.…”

Section: Fine and Ultrafine Pmmentioning

confidence: 80%

“…Sixteen studies were conducted in North America [14, 16-19, 21, 22, 24, 25, 32, 34, 36-39, 43], four studies were conducted in South America [13,23,35,41], four studies took place in Europe [28][29][30][31], and six studies were performed in Asia [15,20,26,27,40,42]. While the vast majority of the publications have focused on acute changes in BP [14-25, 28, 31-35, 37-39, 42, 44], five studies have investigated hypertension as outcome [13,26,27,36,41], and one study has included both BP and hypertension [29]. Consistent with the previous reviews [7,12], we found that in most of the investigated studies a transient increase in BP following short-term exposure to air pollution or some of its components was observed.…”

Section: Short-term Effects Of Air Pollutionmentioning

confidence: 99%

“…The associations of short-term exposure to PM 2.5 with hospital admissions for hypertension were investigated in three studies, all reporting positive findings [27,36,41]. A study in Canada found that per increase in 3-day lag PM 2.5 concentration by 6.2 μg/m 3 the estimated OR for hospital admissions for hypertension was 1.07 (95% CI: 1.01, 1.11) [36].…”

Section: Fine and Ultrafine Pmmentioning

confidence: 99%

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Outdoor Air Pollution and Arterial Hypertension

Li¹,

Yang²,

Fan³

et al. 2018

Blood Pressure - From Bench to Bed

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Air pollution is a major environmental risk factor. There is accumulating evidence that air pollution could induce elevated blood pressure and potentiate hypertension. Acute elevations in the outdoor air pollution levels can trigger immediate or shortly delayed increases in arterial blood pressure. Moreover, few studies suggest that short-term increases in the levels of particulate and gaseous pollutants could lead to an acute onset of hypertension. Prolonged exposure to outdoor air pollution is associated with elevated blood pressure. Furthermore, some longitudinal studies have linked long-term exposure to air pollution with the incidence of hypertension. Various components of air pollution, such as inhalable particulate matter (PM 2.5 ,PM 10), nitrogen oxides, sulfur dioxide, and ozone, have shown associations with blood pressure in some studies. The hypothesized underlying mechanisms include inflammatory reactions and oxidative stress in lungs and in systemic circulation, imbalance of autonomous nervous system, and pathologic changes in vascular endothelium. In addition to "traditional" susceptible groups such as elderly individuals or patients with chronic diseases, children and pregnant women could be especially susceptible to the adverse effects of air pollution. The interplay of air pollution with the related environmental exposures, such as traffic noise and climate change, should be investigated further.

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“…21 In studies conducted in Brazil, the effects of exposure to air pollutants have been shown to be associated with hospitalizations due to cardiovascular diseases such as hypertension, acute myocardial infarction and stroke. 6,[18][19][20] Specifically in relation to the association between exposure to particulate matter and hospitalizations due to ischemic heart disease, a study carried out in São José dos Campos, a city near Taubaté, showed that an increase in PM 10 concentration of 16 µg/m 3 led to a 10% increase in the relative risk of hospitalization. However, in that study, the subjects were not stratified according to sex.…”

Section: Discussionmentioning

confidence: 99%

Fine particulate matter and ischemic heart diseases inrelation to sex. An ecological time series study

et al. 2019

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BACKGROUND: Exposure to some air pollutants is associated with cardiovascular diseases. The objective of this study was to quantify the effect of exposure to fine particulate matter in hospitalizations due to ischemic heart disease and the costs to the healthcare system. DESIGN AND SETTING: Time-series ecological study conducted in Taubaté, Brazil. METHODS: Data on hospitalizations due to ischemic heart diseases (ICD I-20 to I-24) in the municipality of Taubaté (SP), Brazil, among adults of both sexes aged 40 years and over, from August 2011 to July 2012, were obtained from DATASUS. Fine particulate matter (PM 2.5) concentrations were estimated from a mathematical model. Poisson regression was used in statistical analyses to estimate the relative risks of exposure to PM 2.5 for both sexes and after stratification according to sex. The excess of hospitalizations and consequent excess expenditure for the healthcare system were calculated. RESULTS: There were 1040 admissions, among which 382 had ischemic heart diseases (257 males). The mean PM 2.5 concentration was 13.2 µg/m 3 (SD = 5.6). Significant effects from exposure were noted 4 and 5 days after exposure (lag 4 and lag 5) for both sexes and for male sex; for female sex, the effect was 2 days after exposure (lag 2). There were 59 excess hospitalizations for an increase in PM 2.5 concentration of 5 µg/m 3 and excess expenditure of US$ 150,000 for the National Health System. CONCLUSIONS: An excess of hospital admissions due to ischemic heart disease, with excess expenditure, was identified consequent to PM 2.5 exposure.

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Particulate matter and hospital admission due to arterial hypertension in a medium-sized Brazilian city

Cited by 10 publications

References 20 publications

Particulate Matter From Saudi Arabia Induces Genes Involved in Inflammation, Metabolic Syndrome and Atherosclerosis

Particulate Matter From Saudi Arabia Induces Genes Involved in Inflammation, Metabolic Syndrome and Atherosclerosis

Outdoor Air Pollution and Arterial Hypertension

Fine particulate matter and ischemic heart diseases inrelation to sex. An ecological time series study

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