Partitioning of some biomolecules at high pressures to aqueous/organic liquid–liquid phases of the carbon dioxide+water+1-propanol system

Hochdruck‐Flüssig/Flüssig‐Extraktion in Anwesenheit nahekritischen Kohlendioxids

“…Zum einen muss das ternäre phasenbildende Hochdruck-Dreiphasengleichgewicht L 1 L 2 V hochgenau beschrieben werden und zum anderen die Naturstoffverteilung auf die koexistierenden flüssigen Phasen des Dreiphasengleichgewichts. Es gibt vielversprechende Ansätze und einige bereits erfolgreich durchgeführte Modellierungen [5], die allerdings (teilweise) thermodynamisch noch inkonsistent sind.…”

“…3 und 4 gezeigten Ergebnisse zur Verteilung von Digitoxin bzw. Digoxin auf koexistierende Flüssigphasen des Systems CO 2 + H 2 O + 1-Propanol soll der zweite Ansatz erläutert werden [5,8]. Dieser kombinierte Ansatz verläuft in drei Einzelschritten.…”

“…Auch die von Paracoccus seriniphilus produzierte L-Serindehydratase (EC 4.2.1.13) ist die erste, die aus einem marinen Mikroorganismus isoliert wurde. Dieses Enzym katalysiert die irreversible, nichtoxidative Deaminierung von L-Serin zu Pyruvat [5] …”

Partitioning of Ethyl Acetate, Maltol, Glucose, and Fructose to Liquid Phases of the Carbon Dioxide + Water + 1-Propanol System

“…In addition to the basic phase equilibrium phenomenon, research on the partitioning of natural product model compounds on coexisting water-like liquid phases was started. First, experimental results for the partitioning of carbohydrates in ternary system carbon dioxide + water + hydrophilic organic solvent were reported by Pfohl et al 4,5 Recently, Adrian et al [6][7][8] reported a set of experimental data for the partitioning of vanillin and caffeine on coexisting liquid phases in the ternary system carbon dioxide + water + acetone and for the partitioning of eight natural product model compounds in the ternary system carbon dioxide + water + 1-propanol. A process for extraction and separation of cardiac glycosides was discussed by Adrian et al 8 Correlations of partitioning measurements were reported by Pfohl et al 4 and Adrian et al 7 This paper extends the studies on partitioning of natural product model compounds on coexisting liquid phases in the ternary system carbon dioxide + water + 1-propanol.…”

“…First, experimental results for the partitioning of carbohydrates in ternary system carbon dioxide + water + hydrophilic organic solvent were reported by Pfohl et al 4,5 Recently, Adrian et al [6][7][8] reported a set of experimental data for the partitioning of vanillin and caffeine on coexisting liquid phases in the ternary system carbon dioxide + water + acetone and for the partitioning of eight natural product model compounds in the ternary system carbon dioxide + water + 1-propanol. A process for extraction and separation of cardiac glycosides was discussed by Adrian et al 8 Correlations of partitioning measurements were reported by Pfohl et al 4 and Adrian et al 7 This paper extends the studies on partitioning of natural product model compounds on coexisting liquid phases in the ternary system carbon dioxide + water + 1-propanol. It reports experimental data on the partitioning of carbohydrates D-fructose and D-glucose, as well as model compounds ethyl acetate and maltol, on coexisting liquid phases in the ternary system carbon dioxide + water +1-propanol at 313 and 333 K. The experimental results presented here show that the phase equilibrium phenomenon discussed is applicable for isolation of natural products from aqueous solutions, in case of maltol and ethyl acetate, and for purification of aqueous solutions containing D-fructose and D-glucose.…”