Parvovirus B19 infection in thoracic organ transplant recipients

Calvet, A.; Pujol, Marine; Bertocchi, M.; Bastien, O.; Boissonnat, P.; Mornex, Jf

doi:10.1016/s1386-6532(99)00012-8

Cited by 15 publications

(11 citation statements)

References 31 publications

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“…Patients who had seroconverted were 2.6 times more likely to develop anaemia (Table), which is similar to the value found by Calvet et al (1999) in organ transplant recipients. In the present study, the lack of a significant association between anaemia and predisposing factors other than B19V seroconversion reinforces the importance of the role of B19V infection as a cause of anaemia in HIV-infected patients, particularly during periods of high viral activity.…”

Section: Discussionsupporting

confidence: 81%

“…The prevalence of IgM-positive sera (10% -5/53 patients) in that previous study was similar to that observed in our study (10.7% -3/28 patients). However, Calvet et al (1999) detected anti-B19V IgM antibodies in 12/24 (50%) patients who tested positive for B19V in a group of 62 transplanted patients. Compared with the results of the current study, the high proportion of IgM detected in that study may be associated with the shorter interval of collection and testing of serum samples by those authors.…”

Section: Discussionmentioning

confidence: 89%

“…Calvet et al (1999) found a frequent dissociation between the molecular and serological markers of B19V infection in transplant patients; 60/109 PCR-positive specimens showed no evidence of recent infection and only two of the 24 patients with B19V infection had more than 40% of their samples test positive by either serology or PCR. In our study, viraemia was detected in a single serum sample in two/four patients who seroconverted (1 patient seroconverted in 2005 and the other in 2006).…”

Section: Discussionmentioning

confidence: 94%

“…The immune response may be altered by immunosuppression; consequently, genome detection has been largely applied in this clinical context (Kurtzman et al 1989, Calvet et al 1999. Calvet et al (1999) found a frequent dissociation between the molecular and serological markers of B19V infection in transplant patients; 60/109 PCR-positive specimens showed no evidence of recent infection and only two of the 24 patients with B19V infection had more than 40% of their samples test positive by either serology or PCR.…”

Section: Discussionmentioning

confidence: 99%

See 3 more Smart Citations

Parvovirus B19 seroconversion in a cohort of human immunodeficiency virus-infected patients

Azevedo

Setúbal

Camacho

et al. 2012

Mem. Inst. Oswaldo Cruz

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Section: Discussionsupporting

confidence: 81%

Section: Discussionmentioning

confidence: 89%

Section: Discussionmentioning

confidence: 94%

Section: Discussionmentioning

confidence: 99%

See 2 more Smart Citations

Parvovirus B19 seroconversion in a cohort of human immunodeficiency virus-infected patients

Azevedo

Setúbal

Camacho

et al. 2012

Mem. Inst. Oswaldo Cruz

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“…According to Kurtzman et al (1989a), the immune response may be quantitatively and qualitatively altered by immunosuppression or during persistent infections. Consequently, in this clinical context, diagnostic genome detection has been advocated by some authors (Calvet et al 1999). …”

Section: Discussionmentioning

confidence: 99%

Clinical features and laboratory findings of human parvovirus B19 in human immunodeficiency virus-infected patients

Pereira

Garcia

Azevedo

et al. 2014

Mem. Inst. Oswaldo Cruz

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Immunocompromised patients may develop severe chronic anaemia when infected by human parvovirus B19 (B19V). However, this is not the case in human immunodeficiency virus (HIV)-infected patients with good adherence to highly active antiretroviral treatment (HAART). In this study, we investigated the clinical evolution of five HIV-infected patients receiving HAART who had B19V infections confirmed by serum polymerase chain reaction. Four of the patients were infected with genotype 1a strains and the remaining patient was infected with a genotype 3b strain. Anaemia was detected in three of the patients, but all patients recovered without requiring immunoglobulin and/or blood transfusions. In all cases, the attending physicians did not suspect the B19V infections. There was no apparent relationship between the infecting genotype and the clinical course. In the HAART era, B19V infections in HIV-positive patients may be limited, subtle or unapparent.

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Frequent detection of parvovirus B19 genome in the myocardium of adult patients with idiopathic dilated cardiomyopathy

Lotze¹,

Egerer

Tresselt

et al. 2004

Medical Microbiology and Immunology

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Aside from enteroviruses and other viruses, e.g., adenoviruses, which are known to be associated with idiopathic dilated cardiomyopathy (IDC), a cardiac tropism is also attributed to parvovirus B19 (PVB19). The purpose of the present study was to determine the prevalence of enterovirus, adenovirus and PVB19 genomes in the myocardium of adult patients with IDC and to analyze the significance of PVB19 with regard to the course of the disease, as compared to the other cardiotropic viruses. In 52 adult patients with IDC and 10 control patients with normal left ventricular ejection fraction (> or =55%) undergoing coronary artery bypass surgery, myocardial tissue samples were investigated for enteroviral RNA using polymerase chain reaction (PCR) and Southern blot hybridization of the PCR product. Specific nested PCR was used to assess the prevalence of adenovirus and PVB19 DNA, in addition to sequencing of the latter. The clinical and echocardiographic course of the disease was followed for a mean (+/- SD) period of 21.1+/-9.5 months. Fourteen of the 52 patients (27%) were enterovirus-positive, 2/52 (4%) patients were adenovirus-positive, 14/52 (27%) patients were PVB19-positive, 8/52 (15%) patients were enterovirus plus PVB19-positive, and in 14/52 (27%) patients no viral genomes were found. Six patients died during the follow-up period, without any significant difference between the patient groups: 1/14 (7%) in the enterovirus-positive, 0/2 (0%) in the adenovirus-positive, 2/14 (14%) in the PVB19-positive, 1/8 (12.5%) in the enterovirus plus PVB19-positive, and 2/14 (14%) in the virus-negative group. PVB19 genome was found in 4 of the 10 (40%) control patients, but no enterovirus or adenovirus genomes were detected in these patients. In conclusion, in the myocardium of patients with IDC, PVB19 is detectable as frequently as enteroviral genome. PVB19-positive patients with IDC have a rather favorable prognosis and do not differ significantly from the other virus-positive or virus-negative patient groups with respect to survival. Finally, the pathogenetic and prognostic significance of PVB19 in IDC still remains unclear.

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Parvovirus B19 infection in thoracic organ transplant recipients

Cited by 15 publications

References 31 publications

Parvovirus B19 seroconversion in a cohort of human immunodeficiency virus-infected patients

Parvovirus B19 seroconversion in a cohort of human immunodeficiency virus-infected patients

Clinical features and laboratory findings of human parvovirus B19 in human immunodeficiency virus-infected patients

Frequent detection of parvovirus B19 genome in the myocardium of adult patients with idiopathic dilated cardiomyopathy

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