Pathogen inactivation efficacy of Mirasol PRT System and Intercept Blood System for non‐leucoreduced platelet‐rich plasma‐derived platelets suspended in plasma

Abstract

Pathogen inactivation efficacy of Intercept for enveloped viruses was found to be satisfactory. Mirasol showed satisfactory inactivation efficacy for HIV-1 only. The two selected non-enveloped viruses were not inactivated by both systems. Inactivation efficacy of Intercept was more robust for all bacteria tested at high or low titres.

Microbiological Screening of Platelet Concentrates in Europe

“…Prior to the marketing authorization, numerous studies on the performance of these systems were conducted. Focusing on the efficacy of PR, all 3 systems demonstrated significant log reduction of bacteria in platelets [60, 61]. …”

Pathogen reduction through additive-free short-wave uv light irradiation retains the optimal efficacy of human platelet lysate for the expansion of human bone marrow mesenchymal stem cells

“…None of these technologies is reported to be effective on all types of viruses. For example, HIV-1 is only moderately reduced by THERAFLEX UV-Platelets, hepatitis A virus inactivation is not effective with Intercept [59] and Dengue viruses are slightly reduced following treatment with riboflavin and UV light [60]. In addition, the three technologies have been shown to perform inactivation of residual leukocytes [61][62][63], thus lowering the risk of transfusion-associated graft-versus-host disease.…”

Humanes Cytomegalievirus (HCMV)

“…Neue Studienergebnisse belegen, dass frisch serokonvertierte Spender die höchsten Viruskonzentrationen im Verlauf einer HCMV-Infektion haben. Diese Spender waren klinisch asymptomatisch und wurden ohne HCMV-Diagnostik nicht erkannt [9, [152][153][154][155][156][157][158].…”