Pathogen Surveillance in Animals

Kuiken, Thijs; Leighton, F. A.; Fouchier, Ron A. M.; LeDuc, James W.; Peiris, J S Malik; Schudel, Alejandro A.; Stöhr, Klaus; Osterhaus, Albert D. M. E.

doi:10.1126/science.1113310

Cited by 204 publications

(163 citation statements)

References 9 publications

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“…e now live in an era where two-thirds of human infectious diseases and three-quarters of emerging or reemerging infectious diseases are zoonotic in origin, i.e., diseases caused by animal-associated pathogens that can be shared with humans (1)(2)(3)(4). Coupled with the globalization of air travel and commerce and the megamobilization of the food and trade industries, the spread of zoonotic diseases poses a threat to global public health and biosecurity (2,(4)(5)(6)(7)(8)(9)(10).…”

mentioning

confidence: 99%

Pasteurella multocida: from Zoonosis to Cellular Microbiology

2013

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SUMMARY In a world where most emerging and reemerging infectious diseases are zoonotic in nature and our contacts with both domestic and wild animals abound, there is growing awareness of the potential for human acquisition of animal diseases. Like other Pasteurellaceae , Pasteurella species are highly prevalent among animal populations, where they are often found as part of the normal microbiota of the oral, nasopharyngeal, and upper respiratory tracts. Many Pasteurella species are opportunistic pathogens that can cause endemic disease and are associated increasingly with epizootic outbreaks. Zoonotic transmission to humans usually occurs through animal bites or contact with nasal secretions, with P. multocida being the most prevalent isolate observed in human infections. Here we review recent comparative genomics and molecular pathogenesis studies that have advanced our understanding of the multiple virulence mechanisms employed by Pasteurella species to establish acute and chronic infections. We also summarize efforts being explored to enhance our ability to rapidly and accurately identify and distinguish among clinical isolates and to control pasteurellosis by improved development of new vaccines and treatment regimens.

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mentioning

confidence: 99%

Pasteurella multocida: from Zoonosis to Cellular Microbiology

2013

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“…Em ambos os isolados obtidos das duas coletas de lavado traqueal, observou-se resistên-cia para quase todas as classes de antimicrobianos testados na primeira e na segunda coleta, com perfil de resistência antimicrobiana diferente entre as mesmas, sendo todas com resistência múltipla (Quadro 1 e 2). O aparecimento de micro-organismos resistentes aos antibióticos vem crescendo, e segundo Kuiken et al 2005, acredita-se que animais silvestres sejam a fonte de 70% das infecções emergentes. Em estudo realizado para identificar a susceptibilidade de bactérias aos antimicrobianos isoladas a partir de amostras de fezes, água e swab nasal provenientes de um zoológico no Japão observou-se a predominância de E. coli seguida de Klebsiella pneumoniae, e 21,1% dos isolados foram resistentes à ampicilina, cefalotina, estreptomicina, sulfametoxazol-trimetoprim, canamicina, tetraciclina, áci-do nalidíxico , e ciprofloxacina (Ahmed et al 2007).…”

Section: Discussionunclassified

Pneumonia bacteriana em jabuti-piranga (Chelonoidis carbonaria): aspectos clínicos, microbiológicos, radiológicos e terapêutica

et al. 2014

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Pesq. Vet. Bras. 34(9):891-895, setembro 2014 891 RESUMO.-A pneumonia é uma doença respiratória comum na clínica de répteis. Agentes infecciosos são capazes de causar pneumonia primária em répteis mantidos em cativeiro, porém na maioria dos casos, são secundárias a problemas de manejo, higiene e nutricionais. O objetivo desse trabalho foi relatar a ocorrência de pneumonia bacteriana em jabuti-piranga (Chelonoidis carbonaria), e descrever o diagnóstico clínico, microbiológico, radiográfico e a conduta terapêutica. O animal apresentava sinais de distúr- Pneumonia is a common respiratory disease in clinical of reptiles. Infectious agents are capable of causing primary pneumonia in reptiles maintained in captivity, but in most cases are secondary to problems of management, hygiene and nutrition. The aim of this study was to report the occurrence of bacterial pneumonia in red-footed tortoise (Chelonoidis carbonaria), and describe the clinical, microbiologic, radiographic and therapeutic management. The animal showed signs of respiratory disorders and has been described in the clinical history before diagnosis of pneumonia. The radiographic findings were suggestive of pneumonia/pulmonary edema. Based on the displayed radiographic examination and clinical signs began treatment with administration of chloramphenicol (40mg/ kg/SID/IM) for ten days. Were isolated Klebsiella spp. and Citrobacter spp. bacterial culture done collecting endotracheal lavage. Both with multiple antibiotic resistance profile tested. Treatment protocol was instituted using gentamicin (5mg/kg/IM) applications into seven intervals of 72h. There was improvement in clinical signs of the animal, but the presence of nasal secretion was still observed. New radiographic examination, demonstrating slight decrease in the opacity of the right lung field and no significant change in the left lung field in craniocaudal projection was performed. Because of the persistence of clinical signs presented new collection endotracheal material was performed, and there was isolation of Citrobacter spp. and Enterobacter spp. From the results obtained in the antibiogram, was instituted new protocol with the use of amikacin (2.5mg/kg/IM) applications into seven intervals of 72h. After antibiotic therapy, other radiological examination was performed, and showed satisfactory reduction in pulmonary function and clinical signs.

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“…Body condition and disease are intricately linked and neither can be well understood in isolation from the other. Secondly, the emergence of new diseases, re-emergence of old, and pathogen spill-over among wildlife, domestic animals, and people has highlighted the need for e ective and responsive wildlife disease monitoring and surveillance systems today (Kuiken et al, 2005).…”

Section: Carma Network Feedback and Protocol Evaluationmentioning

confidence: 99%

Standardized monitoring of Rangifer health during International Polar Year

Kutz¹,

Ducrocq²,

Cuyler³

et al. 2013

Ran

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Monitoring of individual animal health indices in wildlife populations can be a powerful tool for evaluation of population health, detecting changes, and informing management decisions. Standardized monitoring allows robust comparisons within and across populations, and over time and vast geographic regions. As an International Polar Year Initiative, the CircumArctic Rangifer Monitoring and Assessment network established eld protocols for standardized monitoring of caribou and reindeer (Rangifer tarandus) health, which included body condition, contaminants, and pathogen exposure and abundance. To facilitate use of the protocols, training sessions were held, additional resources were developed, and language was translated where needed. From March 2007 to September 2010, at least 1206 animals from 16 circumpolar herds were sampled in the eld using the protocols. Four main levels of sampling were done and ranged from basic to comprehensive sampling. Possible sources of sampling error were noted by network members early in the process and protocols were modi ed or supplemented with additional visual resources to improve clarity when needed. is is the rst time that such broad and comprehensive circumpolar sampling of migratory caribou and wild reindeer, using standardized protocols covering both body condition and disease status, has been done.

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Pathogen Surveillance in Animals

Cited by 204 publications

References 9 publications

Pasteurella multocida: from Zoonosis to Cellular Microbiology

Pasteurella multocida: from Zoonosis to Cellular Microbiology

Pneumonia bacteriana em jabuti-piranga (Chelonoidis carbonaria): aspectos clínicos, microbiológicos, radiológicos e terapêutica

Standardized monitoring of Rangifer health during International Polar Year

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