2019
DOI: 10.1177/0300985818823666
|View full text |Cite
|
Sign up to set email alerts
|

Pathogenesis of Bohle Iridovirus (Genus Ranavirus) in Experimentally Infected Juvenile Eastern Water Dragons (Intellagama lesueurii lesueurii)

Abstract: Juvenile eastern water dragons (Intellagama lesueurii lesueurii) are highly susceptible to infection with Bohle iridovirus (BIV), a species of ranavirus first isolated from ornate burrowing frogs in Townsville, Australia. To investigate the progression of BIV infection in eastern water dragons, 11 captive-bred juveniles were orally inoculated with a dose of 10 4.33 TCID 50 and euthanized at 3, 6, 8, 10, 12, and 14 days postinfection (dpi). Viral DNA was detected via polymerase chain reaction (PCR) in the liver… Show more

Help me understand this report

Search citation statements

Order By: Relevance

Paper Sections

Select...
3
1

Citation Types

0
8
0

Year Published

2020
2020
2024
2024

Publication Types

Select...
4
2
1

Relationship

2
5

Authors

Journals

citations
Cited by 14 publications
(9 citation statements)
references
References 35 publications
0
8
0
Order By: Relevance
“…This was similar to the progression of disease in orally infected Eastern water dragons in which splenic necrosis precedes hepatic necrosis. 26 Immunolabeling and qPCR results also suggested that the spleen is a primary site of replication in Krefft’s river turtles. Immunolabeling was consistently observed in the spleen from 16 dpi.…”
Section: Discussionmentioning
confidence: 97%
See 3 more Smart Citations
“…This was similar to the progression of disease in orally infected Eastern water dragons in which splenic necrosis precedes hepatic necrosis. 26 Immunolabeling and qPCR results also suggested that the spleen is a primary site of replication in Krefft’s river turtles. Immunolabeling was consistently observed in the spleen from 16 dpi.…”
Section: Discussionmentioning
confidence: 97%
“…In comparison, wood frogs ( Rana sylvatica , Lithobates sylvaticus ) infected with frog virus 3 and Eastern water dragons ( Intellagama lesueurii lesueurii ) infected with BIV developed mild lesions at 2 and 3 dpi, respectively, and were euthanized (or had died) by dpi 14. 11,26 The long incubation period in Krefft’s turtles means that infected yet asymptotic animals may go unnoticed, especially in areas where populations are not routinely monitored. The lack of specificity of clinical signs further complicates detection of ranaviral infection outside of experimental settings.…”
Section: Discussionmentioning
confidence: 99%
See 2 more Smart Citations
“…Histological examination revealed that the condition was largely confined to the epidermis, while all other organs in the animals investigated appeared normal. Skin lesions associated with ranaviral infection have been reported in lizards and turtles, but in most cases internal organs were also infected (29)(30)(31)(32). While there was no detectable bias toward sex or species of turtles, the odds ratio indicates that the larger the turtle, the higher the risk of a lesion, and juveniles were rarely affected.…”
Section: Characteristics Of the Lesionsmentioning
confidence: 90%