Pathogenesis of gallstones: a genetic perspective

Grünhage, F; Lammert, Frank

doi:10.1016/j.bpg.2006.05.007

Cited by 37 publications

(13 citation statements)

References 75 publications

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“…The ESEM images ( Fig. 2a [8] According to Grunhage and Lammert, [5] polymerized calcium bilirubinate precipitates if the ion product of calcium and unconjugated bilirubin exceeds its solubility product and polymerizes slowly in biliary sludge. Finally, the XRD pattern (Figs.…”

Section: Resultsmentioning

confidence: 99%

“…[6] Such analytical studies, incorporating both nondestructive and destructive analytical methodologies, have been conducted worldwide, providing significant information on the formation and composition of gallbladder stones and helping physicians to take prophylactic measures for the patients. [2,3,5] Following the classification of gallbladder stones by Grunhage and Lammert, [5] there exist yellowcolored pure cholesterol stones, black pigment stones, and brown pigment stones, while Jayalakshmi et al [7] refer to three morphological classes: cholesterol, pigment, and mixed stones. Considering the above-mentioned categorization, this study focuses on characteristic bladder calculi with distinctive morphology and structure.…”

mentioning

confidence: 99%

“…[1][2][3][4] Gallbladder stones form when the concentration of cholesterol or bilirubin exceeds the solubility in the bile salt and phospholipid-rich bile and may develop a single, often large stone or many smaller ones, even several thousands. [2,3,5] Human gallstones occur in a variety of shapes, sizes, and crystalline to amorphous structures and range in color from creamy white and yellow to black and brown. There is also variation in the size of stones, ranging from a few millimeters to 5 cm.…”

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confidence: 99%

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Characterization of Gallbladder Stones From Cholelithiasis Patients of Northern Greece, Using Complementary Techniques

Iordanidis

García-Guinea

Giousef

et al. 2013

Spectroscopy Letters

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The present study aims to characterize gallbladder stones surgically removed from patients dwelling in northern Greece. Combined techniques were employed, such as environmental scanning electron microscopy coupled with an energy dispersive system, l Raman spectroscopy, X-ray diffraction, and cathodoluminescence for the determination of morphological, microstructural, and compositional (chemical and mineralogical) characteristics. Four characteristic gallstones were determined: a black pigment, consisting of aragonite and bilirubin; a mixed stone, composed of calcite, oxalates, and phosphates; a cholesterol-rich stone; and a large stone, consisting of uric acid. The importance of using such mineralogical complementary techniques is emphasized in this work. It should be noted that this is the first published analytical characterization of gallbladder stones from northern Greece.

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Section: Resultsmentioning

confidence: 99%

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confidence: 99%

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confidence: 99%

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Characterization of Gallbladder Stones From Cholelithiasis Patients of Northern Greece, Using Complementary Techniques

Iordanidis

García-Guinea

Giousef

et al. 2013

Spectroscopy Letters

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“…Cholelithiasis is increasing among women undergone sterilization or hysterectomy due to obesity and weight gain as a result of increased Thyroid stimulating Hormone concentration and hypo function of thyroid [24,25] . In addition altered dietary nutrient and changed life style predispose for the hyper billiary concentration with lithogenesis and present with encumbrance like eructation ,heaviness in the abdomen, nausea ,vomiting and pain in abdomen, compel the patient to seek urgent care to ensure relief of agonizing pain but cholecystectomy though relieve agonizing pain but make life agonizing permanently due to future altered protein and fat metabolism caused by absence of bile to activate protease and lipase secreted from pancreas.…”

Section: Discussionmentioning

confidence: 99%

Cholelithiasis and Ayurveda

Shankar¹,

Shankar²,

Shankar³

2017

IJCAM

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Cholelithiasis in female is increasing rampantly among obese [1,2], hyperlipidemic and hypo functioning thyroid women who undergone tube ligation or hysterectomy may be synergized by increasing toxic non nutrients in diet and changed life style, Common surgical preference Cholecystectomy and Choledochotomy though relieve the agonizing pain but alter digestion permanently which predisposes for the continuance of the presentation like heaviness in the abdomen, heart burn, eructation, lethargy, bowel irregularity in spite of dietary restriction.Placebo based control study to evaluate a herb mineral composit in 216 cases affirm its worth in relieving clinical presentation and USG confirmation in majority cases with grade I clinical response while control group shows only transient symptomatic relief. 3 years post therapy follow up and dietary restriction with maintenance dose of 1 pill daily, none had any bowel irregularity or any evident cholelithiasis or hyperlipidemia.

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“…This increasing frequency, related to different epidemiological factors and diseases, prompted us to carry out an analytical investigation on this kind of human stones. Such analytical studies, incorporating both non-destructive and destructive analytical methodologies, have been conducted worldwide, providing significant information on the formation and composition of human calculi and helping the physicians to take prophylactic measures for the patients (Grunhage and Lammert, 2006;Abboud 2008aAbboud , 2008b.…”

Section: Introductionmentioning

confidence: 99%

Analytical geochemistry in the service of medicine: An experimental study of urinary stones from Northern Greece

Iordanidis¹,

García-Guinea

2017

geosociety

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Knowledge of the precise human biomineral composition may allow physicians to recommend an appropriate prophylactic therapy for the patient and thus prevent or delay the stone recurrence. The present study focuses on the application of complementary analytical techniques to the characterization of human urinary stones. Several gallbladder and renal stone samples were obtained from patients dwelling in areas of northern Greece. A comprehensive analytical study took place, employing the following, common in analytical geochemistry, techniques: Environmental Scanning Electron Microscopy (ESEM) coupled to Energy Dispersive System (EDS), X-Ray Diffraction (XRD), thermogravimetry (TG), μRaman spectroscopy and Cathodoluminescence (CL). A detailed determination of morphological, micro-structural, molecular, chemical and mineralogical characteristics of the urinary stone samples was achieved. It was evident by our study the application of powerful analytical techniques could substantially help the medical advisors to ascribe a medical treatment of diseases related to stone formation.

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Pathogenesis of gallstones: a genetic perspective

Cited by 37 publications

References 75 publications

Characterization of Gallbladder Stones From Cholelithiasis Patients of Northern Greece, Using Complementary Techniques

Characterization of Gallbladder Stones From Cholelithiasis Patients of Northern Greece, Using Complementary Techniques

Cholelithiasis and Ayurveda

Analytical geochemistry in the service of medicine: An experimental study of urinary stones from Northern Greece

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