Pathogenic Mechanisms of Thrombosis in Antiphospholipid Syndrome (APS)

Sikara, Marina; Grika, E.; Vlachoyiannopoulos, Panayiotis G.

doi:10.5772/25522

Cited by 2 publications

(1 citation statement)

References 124 publications

(109 reference statements)

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“…Herein, we report a case of a patient with ITP and concomitant APS and MGUS. The literature on this subject explains different overlapping mechanisms such as aPL-mediated activation of platelets, of endothelial cells or even impaired fibrinolysis [9]. Among aPL, lupus anticoagulant, detected in above-mentioned patient, is the strongest risk factor for developing thrombosis [10].…”

Section: Introductionmentioning

confidence: 99%

Management of patient with immune thrombocytopenia with antiphospholipid syndrome and monoclonal gammopathy of undetermined significance

et al. 2021

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Immune thrombocytopenia with antiphospholipid syndrome and monoclonal gammopathy of undetermined significance poses therapeutic dilemmas – whether we should modify the immune thrombocytopenia treatment in antiphospholipid syndrome, what is the influence of monoclonal gammopathy of undetermined significance on the course of immune thrombocytopenia and whether we should and how to prevent the progression of monoclonal gammopathy of undetermined significance to multiple myeloma.

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Section: Introductionmentioning

confidence: 99%

Management of patient with immune thrombocytopenia with antiphospholipid syndrome and monoclonal gammopathy of undetermined significance

et al. 2021

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Immunological parameters of recurrent miscarriages among women in Thi-Qar province

Hamadi

Lafta

2022

JMedLife

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Recurrent miscarriage (RM) is defined as the loss of pregnancy three or more consecutive times in the first and second trimester, which in some cases occurs due to immune abnormalities. This study aimed to assess some immunological parameters in women with recurrent miscarriages, including the level of antiphospholipid antibody (APA), anticardiolipin (ACA), antinuclear antibody (ANA), complement C3 and C4, and interleukine-3 (IL-3). We included 100 patients together with 100 healthy women as a control. ELIZA was used to measure some types of autoantibodies. APA and ACA significantly increased (P≤0.05) in patients compared to control. In addition, 29% of the patients were positive for antinuclear antibodies (ANA), while the control subjects had negative results for these autoantibodies. Regarding the complement, the serum levels of C3 and C4 were significantly elevated in the serum level of patients when compared to the control group, but in treated patients (heparin and low-dose aspirin), the levels of the complement (C3 and C4) showed a significant decrease in patients compared to total controls. Cytokine level (IL-3) significantly decreased in untreated patients 302.78 pg/ml compared to treated patients (741.57 pg/ml). Antiphospholipid antibodies are more prevalent among women with recurrent miscarriages and are also believed to be the result of abnormal autoimmune activation.

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Pathogenic Mechanisms of Thrombosis in Antiphospholipid Syndrome (APS)

Cited by 2 publications

References 124 publications

Management of patient with immune thrombocytopenia with antiphospholipid syndrome and monoclonal gammopathy of undetermined significance

Management of patient with immune thrombocytopenia with antiphospholipid syndrome and monoclonal gammopathy of undetermined significance

Immunological parameters of recurrent miscarriages among women in Thi-Qar province

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