Pathogenicity Biofilm formation of Enterococcus faecalis

Asmah, Nur

doi:10.24815/jds.v5i1.20011

Cited by 2 publications

(1 citation statement)

References 20 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…E. faecalis induced an NF-B inflammatory response and impaired DNA damage response and cell cycle control gene expression (Strickertsson et al, 2013). This bacterium has cytolysin and hyaluronidase, which could facilitate migration and collagen fragmentation related to inflammation in host cells (Asmah, 2020). The previous study revealed that the infection of the macrophage precursors by E. faecalis could restrict the plasticity of macrophage change into M2 macrophages (Elashiry et al, 2021).…”

Section: Discussionmentioning

confidence: 99%

Antibacterial activity of Stachytarpheta jamaicensis (L.) Vahl roots extract on some bacteria proteins: An in silico and in vitro study

Utami¹,

Diana²,

Arifin³

et al. 2022

J Pharm Pharmacogn Res

View full text Add to dashboard Cite

Context: Stachytarpheta jamaicensis (L.) Vahl plant is used for traditional therapy because of its content, including flavonoids, alkaloids, tannins, saponins, terpenoids, and coumarins. Aims: To determine the antibacterial ability of S. jamaicensis roots extract (SJRE) on some selected mouth bacteria through in vitro and in silico studies. Methods: Phytochemical analysis and liquid chromatography-high resolution mass spectrometry (LC-HRMS) were done to explore the active compounds on SJRE. Absorption, distribution, metabolism, excretion and toxicity prediction, molecular docking simulation and visualization of luvangetin, and xanthyletin as anti-inflammatory and antibacterial were investigated in silico. The minimum inhibitory concentration (MIC) and minimum bactericidal concentration (MBC) of SJRE against Aggregatibacter actinomycetemcomitans, Enterococcus faecalis, and Actinomyces spp. were calculated. Results: Luvangetin and xanthyletin are good candidate drug molecules with low toxicity. Xanthyletin has higher binding activity than luvangetin to TNF-α, IL-6, IL-10, peptidoglycan, flagellin, and dectin protein. SJRE exhibited a high antibacterial ability, and MIC. This extract inhibits the growth of A. actinomycetemcomitans, E. faecalis and Actinomyces spp. at various concentrations 2000, 8000, and 8000 µg/mL, respectively, with statistically significant differences (p = 0.0001; p<0.05). Conclusions: SJRE has an antibacterial ability, and 2000 µg/mL SJRE may act as an antibacterial agent in vitro. In addition, xanthyletin in SJRE has a potential role as an antibacterial and anti-inflammatory in silico.

show abstract

Section: Discussionmentioning

confidence: 99%

Antibacterial activity of Stachytarpheta jamaicensis (L.) Vahl roots extract on some bacteria proteins: An in silico and in vitro study

Utami¹,

Diana²,

Arifin³

et al. 2022

J Pharm Pharmacogn Res

View full text Add to dashboard Cite

show abstract

Microbiological Evaluation of Water Used in Dental Units

Błaszczyk

Pajączkowska

Nowicka

et al. 2022

Water

View full text Add to dashboard Cite

In modern dentistry, dental units are used for the treatment of patients’ teeth, and they need water to operate. Water circulates in a closed vessel system and finally reaches the mucous membranes of the patient as well as the dentist themselves. Therefore, the microbiological safety of this water should be a priority for physicians. This study aims to identify and determine the microbial count, expressed in CFU/mL, in water samples from various parts of the dental unit that are in direct contact with the patient. Thirty-four dental units located in dentistry rooms were analysed. The dentistry rooms were divided into three categories: surgical, conservative, and periodontal. It was found that in surgical rooms, the bacterial count was 1464.76 CFU/mL, and the most common bacterium was Staphylococcus pasteuri—23.88% of the total bacteria identified. In dentistry rooms where conservative treatments were applied, the average bacterial concentration was 8208.35 CFU/mL, and the most common bacterium was Ralsonia pickettii (26.31%). The periodontal rooms were also dominated by R. pickettii (45.13%), and the average bacterial concentration was 8743.08 CFU/mL. Fungi were also detected. Rhodotorula spp., Alternaria spp., and Candida parapsilosis were found to be the most common bacteria which are potentially harmful. This study indicates the need for effective decontamination of the water that is used in dental units and for constant monitoring of the level of contaminants present in the closed vessel system.

show abstract

Pathogenicity Biofilm formation of Enterococcus faecalis

Cited by 2 publications

References 20 publications

Antibacterial activity of Stachytarpheta jamaicensis (L.) Vahl roots extract on some bacteria proteins: An in silico and in vitro study

Antibacterial activity of Stachytarpheta jamaicensis (L.) Vahl roots extract on some bacteria proteins: An in silico and in vitro study

Microbiological Evaluation of Water Used in Dental Units

Contact Info

Product

Resources

About