Pathological features of mucinous carcinoma of the breast are favourable for breast-conserving therapy

Anan, Keisei; Mitsuyama, Shoshu; Tamae, Keiyoshi; Nishihara, Kazuyoshi; Iwashita, Takuya; Abe, Yuzi; Ihara, Takaaki; Nakahara, Shosaku; Katsumoto, F; Toyoshima, Satoshi

doi:10.1053/ejso.2001.1142

Cited by 58 publications

(45 citation statements)

References 27 publications

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“…For example, mucinous carcinomas show higher ADC values than IDC, 7,20 but lymph node metastasis of mucinous carcinoma of the breast is rare. 21 DiŠerences in tumor size might also aŠect the results, but Kim's group did not detail tumor size. We excluded patients with DCIS or IDC with invasive foci smaller than one cm because we thought the signal intensity of small lesions was unreliable on the ADC maps with the low resolution.…”

Section: Discussionmentioning

confidence: 96%

Correlations between Apparent Diffusion Coefficient Values and Prognostic Factors of Breast Cancer

et al. 2013

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Purpose: We investigated possible correlations between apparent diŠusion coe‹cient (ADC) values and prognostic factors of breast cancer.Methods: We retrospectively evaluated 81 patients who underwent magnetic resonance (MR) imaging of the breast and were diagnosed pathologically with invasive ductal carcinoma (IDC) not otherwise speciˆed with invasive foci one cm or larger. We excluded ductal carcinoma in situ and IDC with invasive foci smaller than one cm because small lesions decrease the reliability of signal intensity of diŠusion-weighted imaging (DWI). We also excluded special type cancers. We used t-test to compare the mean ADC values of cancers of Stage pT1 (Ã2 cm) versus pT2 or 3 (À2 cm), cancers with versus without vascular invasion, axillary lymph node (N)-positive versus N-negative cancers, estrogen receptor (ER)-positive versus ER-negative cancers, and progesterone receptor (PgR)-positive versus PgRnegative cancers. We analyzed correlations between the ADC value with nuclear grade (NG) and human epidermal growth factor receptor 2 (HER2) score by rank test using Spearman's correlation coe‹cient.Results: The mean ADC value was signiˆcantly higher for N-positive (n＝28; 0.97±0.20 ×10 -3 mm 2 /s) than N-negative cancers (n＝53; 0.87±0.17×10 Conclusion: ADC values were higher for N-positive and ER-negative breast cancers than N-negative and ER-positive cancers.

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Section: Discussionmentioning

confidence: 96%

Correlations between Apparent Diffusion Coefficient Values and Prognostic Factors of Breast Cancer

et al. 2013

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“…Just as tumor size was not a significant prognostic factor [7], the extent of surgery also did not influence survival. Anan et al [11] suggested that patients with PMBC, except for those invading the local skin, are suitable candidates for breast-conserving therapy, probably even in the presence of large tumors up to 5 cm in diameter [11]. All patients underwent axillary node dissection in our review.…”

Section: Discussionmentioning

confidence: 99%

Pure Mucinous Breast Carcinoma: A Favorable Subtype

Yang

Chun-Hong

et al. 2013

Breast Care

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Background: Pure mucinous breast carcinoma is a relatively rare subtype of breast malignancy. This study is to investigate the clinical and pathologic features of pure mucinous breast carcinoma. Patients andMethods: A retrospective review of our database of patients who presented with breast cancer was performed. The medical records of 1,060 patients with invasive breast cancer who underwent surgery were reviewed. Results: 28 patients with pure mucinous breast cancer were identified. The mean age was 55.28 ± 15.73 years. 17 patients underwent modified radical mastectomy; 11 underwent breast-conserving therapy. The tumor size was T1 in 19 patients, T2 in 8 patients, and T3 in 1 patient. None of the patients had lymph node metastasis. There was no distant metastasis. 18 were stage I, and 10 were stage II. Estrogen receptor, progesterone receptor, HER-2, and P53 were positive in 96, 93, 0, and 28%, respectively. Median follow-up was 42 months (range 1-84 months). 1 patient had local recurrence. The overall survival rate was 100%. Conclusion: Pure mucinous breast carcinoma has a favorable prognosis. Less invasive treatment might be optional. Larger data samples with longer follow-up would be necessary to gain a better understanding of this disease.

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“…In our case both ER and PR were positive. Only 3-15% of pure variety shows axillary node metastasis compared to 33-46% of the mixed type 5,12 . In the present case, there was no lymph node metastasis.…”

Section: Case Report Discussionmentioning

confidence: 95%

Mucinous carcinoma of breast: FNAC as effective diagnostic modality

et al. 2013

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Mucinous carcinoma of the breast in pure form comprises only 2% of all breast cancers. Pure mucinous carcinoma of the breast have better prognosis. They are usually having higher incidence in peri-menopausal and post-menopausal age group. We report a 32-year-old female, clinically suspected to have benign breast disease, diagnosed as mucinous carcinoma of the breast on FNAC. In such cases, there is always a high probability of missing the diagnosis at imaging because of the absence of established radiological signs of malignancy such as calcification and spiculation. In this case imaging was not helpful and diagnosis was ascertained by FNAC. This case further strongly substantiates, Fine needle aspiration cytology as rapid , highly sensitive and highly specific diagnostic investigation of choice for management of breast lumps .

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Pathological features of mucinous carcinoma of the breast are favourable for breast-conserving therapy

Cited by 58 publications

References 27 publications

Correlations between Apparent Diffusion Coefficient Values and Prognostic Factors of Breast Cancer

Correlations between Apparent Diffusion Coefficient Values and Prognostic Factors of Breast Cancer

Pure Mucinous Breast Carcinoma: A Favorable Subtype

Mucinous carcinoma of breast: FNAC as effective diagnostic modality

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