Pathology of Lymphatic Filariasis

Goel, Trilok Chandra; Goel, Apul

doi:10.1007/978-981-10-2257-9_5

Cited by 9 publications

(20 citation statements)

References 12 publications

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“…In Tokyo, Yushitaro Matsuura found a female adult worm in an inguinal lymph node (1896). Later, a lot of work was done in defining various manifestations of filariasis and the aim of current researches is concentrated on prevalence, treatment, transmission cycles, and newly discovered species [6][7][8][9][10].…”

Section: Some Early Scientific Discoveries In Filariasis History Inclmentioning

confidence: 99%

“…After mating, the females produce numerous microfilariae, which migrate into the lymphatic system and spread through the bloodstream (Fig. 5) [7,8,14,18,[23][24][25].…”

Section: Review Articlementioning

confidence: 99%

“…• Blood tests: Blood counts are done, especially the eosinophils, in to the characteristics of the stage larva (L3) in human, such as the number and position of caudal nuclei, cephalic space, and the presence or absence of sheath (Fig. 9) [5,[7][8][9]15,24,35,36]. • Identification of microfilariae in a urine and hydrocele fluid: This is done by centrifuging the fluids samples, the resulting deposits are put on a slide, and examined under the microscope [7,9,30].…”

Section: Diagnosismentioning

confidence: 99%

“…9) [5,[7][8][9]15,24,35,36]. • Identification of microfilariae in a urine and hydrocele fluid: This is done by centrifuging the fluids samples, the resulting deposits are put on a slide, and examined under the microscope [7,9,30]. • Identification of adult worms in lymphatics: The motile adult worms can be seen within the lymphatics of scrotum, breast, thigh, and the spermatic cord in infected tissue using ultrasonography [5,7,9,15,36].…”

Section: Diagnosismentioning

confidence: 99%

“…[TropBio, Australia], immunochromatographic card test), antibody assays, and polymerase chain reaction [5,7,8,9,15,24,30,37,38].…”

Section: • Immunological Tests: Such As Antigen Assays (Tropbio Og4c3mentioning

confidence: 99%

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Lymphatic Filariasis: An Overview

Al-Tameemi

Kabakli

2019

Asian J Pharm Clin Res

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Lymphatic filariasis (LF) is a tropical disease caused by infection with the parasitic filarial worms: Wuchereria bancrofti, Brugia malayi, and Brugia timori. The symptoms of this chronic disease appear in adults (in men more than in women) and include damage to the lymphatic system, arms, legs, and genitals, which cause significant pain, reducing productivity, and social problems. LF is a cause of continued disability, pain, disfigurement, and sexual disability in the world, so the knowledge of the disease and the infection control is very important. In addition to the importance of prevention, that includes giving medicine and using controlling ways of mosquitoes. Moreover, the prevention of disease is important, that includes giving medicine and using controlling ways of mosquitoes. However, although the efforts of health organizations to reduce the LF infections, there are still many challenges including the early diagnosis and control of infection among people.

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Section: Some Early Scientific Discoveries In Filariasis History Inclmentioning

confidence: 99%

“…After mating, the females produce numerous microfilariae, which migrate into the lymphatic system and spread through the bloodstream (Fig. 5) [7,8,14,18,[23][24][25].…”

Section: Review Articlementioning

confidence: 99%

Section: Diagnosismentioning

confidence: 99%

Section: Diagnosismentioning

confidence: 99%

“…[TropBio, Australia], immunochromatographic card test), antibody assays, and polymerase chain reaction [5,7,8,9,15,24,30,37,38].…”

Section: • Immunological Tests: Such As Antigen Assays (Tropbio Og4c3mentioning

confidence: 99%

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Lymphatic Filariasis: An Overview

Al-Tameemi

Kabakli

2019

Asian J Pharm Clin Res

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Inherent biomechanical traits enable infective filariae to disseminate through collecting lymphatic vessels

et al. 2019

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Filariases are diseases caused by arthropod-borne filaria nematodes. The related pathologies depend on the location of the infective larvae when their migration, the asymptomatic and least studied phase of the disease, comes to an end. To determine factors assisting in filariae dissemination, we image Litomosoides sigmodontis infective larvae during their escape from the skin. Burrowing through the dermis filariae exclusively enter pre-collecting lymphatics by mechanical disruption of their wall. Once inside collectors, their rapid and unidirectional movement towards the lymph node is supported by the morphology of lymphatic valves. In a microfluidic maze mimicking lymphatic vessels, filariae follow the direction of the flow, the first biomechanical factor capable of helminth guidance within the host. Finally, non-infective nematodes that rely on universal morpho-physiological cues alone also migrate through the dermis, and break in lymphatics, indicating that the ability to spread by the lymphatic route is an ancestral trait rather than acquired parasitic adaptation.

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The efficacy of change in limb volume on functional mobility, health-related quality of life, social appearance anxiety, and depression in patients with lower extremity lymphedema

Şahinoğlu¹,

Ergin

Karadibak

2022

Phlebology

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Objectives This study aims to investigate the impact of change in limb volume on the levels of functional mobility, health-related quality of life, social appearance anxiety, and depression before and after complex decongestive physiotherapy in patients with lower extremity lymphedema. Method Twenty-seven patients with unilateral lower extremity lymphedema were included. The treatment period was 20 sessions. The outcome measures were the limb volume, the Timed Up and Go test, the Short Form-36, the Social Appearance Anxiety Scale, and the Beck Depression Inventory. Results A statistically significant decrease in the limb volume ( p < 0.001) and statistically significant improvements in the Timed Up and Go test performance ( p < 0.001), the Short Form-36 Physical Component Summary score ( p < 0.01), the Social Appearance Anxiety Scale score ( p < 0.001), and the Beck Depression Inventory score ( p < 0.001) were found. No statistically significant difference was found on the Short Form-36 Mental Component Summary score ( p > 0.05). Conclusion The decrease in the limb volume improves the functional mobility, physical health-related quality of life, social appearance anxiety, and depression in patients with lower extremity lymphedema, but not the mental health-related quality of life.

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Pathology of Lymphatic Filariasis

Cited by 9 publications

References 12 publications

Lymphatic Filariasis: An Overview

Lymphatic Filariasis: An Overview

Inherent biomechanical traits enable infective filariae to disseminate through collecting lymphatic vessels

The efficacy of change in limb volume on functional mobility, health-related quality of life, social appearance anxiety, and depression in patients with lower extremity lymphedema

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