Pathology of Whooper Swans (Cygnus cygnus) Infected with H5N1 Avian Influenza Virus in Akita, Japan, in 2008

Ogawa, Shuji; Yamamoto, Yu; Yamada, Manabu; Mase, Masaji; Nakamura, Kikuyasu

doi:10.1292/jvms.001377

Cited by 6 publications

(5 citation statements)

References 14 publications

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“…The findings are also in accordance with natural infection of tufted ducks with clade 2.2 virus (Bröjer et al, 2009) and clade 2.3.3 virus (Abdo et al, 2014). Lesions are also comparable to those seen in whooper swans (Ogawa et al, 2009;Okamatsu et al, 2010) and in ruddy shelducks and bar-headed geese experimentally infected with clade 2.3.2HPAI-H5N1 virus (A/bar-headed goose/ Mongolia/X53/2009) (Nemeth et al, 2013).…”

Section: Discussionsupporting

confidence: 83%

“…Studies in naturally infected whooper swans (Cygnus cygnus) (Ogawa et al, 2009;Okamatsu et al, 2010) in Japan as well as experimentally infected domestic ducks , ruddy shelducks (Tadorna ferruginea) and bar-headed geese (Nemeth et al, 2013) showed that the clade 2.3.2 viruses are highly pathogenic in wild birds. On the other hand, other data suggest that some of the clade 2.3.2 viruses are not as highly pathogenic since they were demonstrated in apparently healthy ducks (Kajihara et al, 2011;Kim et al, 2011).…”

Section: Introductionmentioning

confidence: 99%

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Pathogenicity and tissue tropism of currently circulating highly pathogenic avian influenza A virus (H5N1; clade 2.3.2) in tufted ducks ( Aythya fuligula )

Bröjer

Amerongen

Bildt

et al. 2015

Veterinary Microbiology

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Section: Discussionsupporting

confidence: 83%

Section: Introductionmentioning

confidence: 99%

Pathogenicity and tissue tropism of currently circulating highly pathogenic avian influenza A virus (H5N1; clade 2.3.2) in tufted ducks ( Aythya fuligula )

Bröjer

Amerongen

Bildt

et al. 2015

Veterinary Microbiology

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“…These lesions were found in all examined mute swans (15/15). Same results were obtained in mute swans naturally and experimentally infected with AIV H5N1 [6][7][8][9][10]. In contrast, there were no visible macroscopic lesions in the pancreas of infected hens.…”

Section: Resultssupporting

confidence: 75%

Morphological Differences of Pancreatic Lesions in Mute Swans and Hens Naturally Infected with Highly Pathogenic Avian Influenza Virus H5N8

et al. 2018

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During the epizootic of highly pathogenic avian influenza subtype H5N8 in Serbia in the winter of 2016-2017, the highest percent of mortality due to this infection was recorded in mute swans (Cygnus olor). Besides mute swans, avian influenza virus subtype H5N8 was also diagnosed in a small number of hens in rural households. Pancreatic tissues from avian influenza H5N8 positive mute swans and hens that died during this outbreak were collected to determine the character of morphological lesions and the distribution of the viral antigen in this organ. Macroscopic examination of the pancreas of mute swans revealed hemorrhages as well as necrosis, while there were no macroscopic visible lesions in the pancreas of infected hens. Despite the different macroscopic finding, microscopic examination of the pancreas of both infected bird species revealed lesions in the form of acute pancreatitis and multifocal acinar necrosis. The viral antigen was abundantly expressed in the cytoplasm and nucleus of necrotic cells, as well as in macrophages in both examined bird species. Immunohistochemical expression of the viral antigen in the pancreas was strongly consistent with histological lesions. According to the above described findings, it could be concluded that highly pathogenic avian influenza virus H5N8 has a high affinity to pancreatic tissue in both mute swans and hens and the distribution and the character of the lesions in the pancreas are similar in both bird species.

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“…showed high mortality by infection with HPAIV [10]. There are few reports on the pathology of swans naturally infected with H5N1 HPAIV [11,12].…”

Section: Introductionmentioning

confidence: 99%

Antigenic, genetic, and pathogenic characterization of H5N1 highly pathogenic avian influenza viruses isolated from dead whooper swans (Cygnus cygnus) found in northern Japan in 2008

et al. 2010

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In April and May 2008, whooper swans (Cygnus cygnus) were found dead in Hokkaido in Japan. In this study, an adult whooper swan found dead beside Lake Saroma was pathologically examined and the identified H5N1 influenza virus isolates were genetically and antigenically analyzed. Pathological findings indicate that the swan died of severe congestive edema in the lungs. Phylogenetic analysis of the HA genes of the isolates revealed that they are the progeny viruses of isolates from poultry and wild birds in China, Russia, Korea, and Hong Kong. Antigenic analyses indicated that the viruses are distinguished from the H5N1 viruses isolated from wild birds and poultry before 2007. The chickens vaccinated with A/duck/Hokkaido/Vac-1/2004 (H5N1) survived for 14 days after challenge with A/whooper swan/Hokkaido/1/2008 (H5N1), although a small amount of the challenge virus was recovered from the tissues of the birds. These findings indicate that H5N1 highly pathogenic avian influenza viruses are circulating in wild birds in addition to domestic poultry in Asia and exhibit antigenic variation that may be due to vaccination.

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Pathology of Whooper Swans (Cygnus cygnus) Infected with H5N1 Avian Influenza Virus in Akita, Japan, in 2008

Cited by 6 publications

References 14 publications

Pathogenicity and tissue tropism of currently circulating highly pathogenic avian influenza A virus (H5N1; clade 2.3.2) in tufted ducks ( Aythya fuligula )

Pathogenicity and tissue tropism of currently circulating highly pathogenic avian influenza A virus (H5N1; clade 2.3.2) in tufted ducks ( Aythya fuligula )

Morphological Differences of Pancreatic Lesions in Mute Swans and Hens Naturally Infected with Highly Pathogenic Avian Influenza Virus H5N8

Antigenic, genetic, and pathogenic characterization of H5N1 highly pathogenic avian influenza viruses isolated from dead whooper swans (Cygnus cygnus) found in northern Japan in 2008

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