Pathophysiologic Responses of Sheep to Brief High-Level Nitrogen Dioxide Exposure

Januszkiewicz, Adolph J.; Snapper, James R.; Sturgis, Jonathan W.; Rayburn, Daniel B.; Dodd, Kenneth T.; Phillips, Yancy Y.; Ripple, Gary R.; Sharpnack, Douglas D.; Coulson, Nicholas M.; Bley, John A.

doi:10.3109/08958379209145314

Cited by 8 publications

(5 citation statements)

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“… 34 In another study, inhaled NO 2 increased lung resistance, respiratory rate, and minute ventilation. 35 Furthermore, NO 2 and SO 2 can cause wheezing and breathlessness 36 and enhance airway response to inhaled allergens. 37 Increased indoor PM concentrations were associated with asthma exacerbation in children.…”

Section: Discussionmentioning

confidence: 99%

Association of Mechanical Ventilation and Flue Use in Heaters With Asthma Symptoms in Japanese Schoolchildren: A Cross-Sectional Study in Sapporo, Japan

Shi

Araki

Ukawa

et al. 2014

Journal of Epidemiology

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BackgroundUse of fuel heaters is associated with childhood asthma. However, no studies have evaluated the associations of flue use and mechanical ventilation (ventilation) with asthma symptoms in schoolchildren.MethodsThis cross-sectional study investigated schoolchildren in grades 1 through 6 (age 6–12 years) in Sapporo, Japan. From November 2008 through January 2009, parents completed questionnaires regarding their home environment and their children’s asthma symptoms.ResultsIn total, 4445 (69.5%) parents of 6393 children returned the questionnaire. After excluding incomplete responses, data on 3874 children (60.6%) were analyzed. The prevalence of current asthma symptoms and ever asthma symptoms were 12.8% and 30.9%, respectively. As compared with electric heaters, current asthma symptoms was associated with use of flued heaters without ventilation (OR = 1.62; 95% CI, 1.03–2.64) and unflued heaters with ventilation (OR = 1.77; 95% CI, 1.09–2.95) or without ventilation (OR = 2.23; 95% CI, 1.31–3.85). Regardless of dampness, unflued heaters were significantly associated with current asthma symptoms in the presence and absence of ventilation.ConclusionsUse of unflued heaters was associated with current asthma symptoms, regardless of dampness. In particular, the prevalence of current asthma symptoms was higher in the absence of ventilation than in the presence of ventilation. Ever asthma symptoms was only associated with use of unflued heaters without ventilation. Consequently, use of fuel heaters, especially those that have no flue or ventilation, deserves attention, as their use might be associated with childhood asthma symptoms.

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Section: Discussionmentioning

confidence: 99%

Association of Mechanical Ventilation and Flue Use in Heaters With Asthma Symptoms in Japanese Schoolchildren: A Cross-Sectional Study in Sapporo, Japan

Shi

Araki

Ukawa

et al. 2014

Journal of Epidemiology

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“…The pathophysiological effect of NO 2 on the respiratory system may include early alterations in airway calibre and/or viscoelastic properties of the peripheral lung and delayed or impaired gas exchange and pulmonary function abnormalities [34]. Children are particularly vulnerable to the effects of air pollution as they breathe 50% more air per kg of body weight than adults [35].…”

Section: Discussionmentioning

confidence: 99%

The respiratory health effects of nitrogen dioxide in children with asthma

Gillespie-Bennett¹,

Pierse²,

Wickens³

et al. 2010

Eur Respir J

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There is growing evidence that asthma symptoms can be aggravated or events triggered by exposure to indoor nitrogen dioxide (NO 2 ) emitted from unflued gas heating.The impact of NO 2 on the respiratory health of children with asthma was explored as a secondary analysis of a randomised community trial, involving 409 households during the winter period in 2006 (June to September).Geometric mean indoor NO 2 levels were 11.4 mg?m -3, while outdoor NO 2 levels were 7.4 mg?m -3 . Higher indoor NO 2 levels (per logged unit increase) were associated with greater daily reports of lower (mean ratio 14, 95% CI 1.12-1.16) and upper respiratory tract symptoms (mean ratio 1.03, 95% CI 1.00-1.05), more frequent cough and wheeze, and more frequent reliever use during the day, but had no effect on preventer use. Higher indoor NO 2 levels (per logged unit increase) were associated with a decrease in morning (-17.25 mL, 95% CI -27.63--6.68) and evening (-13.21, 95% CI -26.03--0.38) forced expiratory volume in 1 s readings. Outdoor NO 2 was not associated with respiratory tract symptoms, asthma symptoms, medication use or lung function measurements.These findings indicate that reducing NO 2 exposure indoors is important in improving the respiratory health of children with asthma.

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“…In studies involving chronic and/or intermittent exposure to NO, the importance of such reporting would be tempered by other factors such as the influence of the natural protective and adaptive processes occurring over time. Animals used in NO 2 models include mice, rats, hamsters, rabbits, dogs, sheep, monkeys and humans (The National Research Council, 1977: Januszkiewicz et al, 1992Mobsenin and Gee, 1987). Knowledge of the physiological and anatomical nuances of each species is critical in the interpretation of research results.…”

Section: Experimental Models and Research Issuesmentioning

confidence: 99%

“…The diverse patterns of exposure studied include single, intermittent, continuous, and continuous with intermittent boluses (Guidotti, 1980;Frederick et al, 1987;Gelzleichter et al, 1992b). Most studies in the civilian literature have investigated the effects of relatively low level NO, exposure whereas the US Army studies have concentrated on acute high-level NO 2 exposure (Januszkiewicz et al, 1992). Some studies have investigated the differences in distribution of histological damage as well as biochemical alterations (Kubota et al, 1987;Cavanagh and Morris, 1987).…”

Section: Experimental Models and Research Issuesmentioning

confidence: 99%

“…Various animal studies, both early and more current, have described pathophysiologic changes that include increased airway resistance, decreased tidal volume, increased respiratory rate, hypoxemia, mild methemoglobinemia and decreased lung complidnce in response to "acute high-dose" NO, exposure (The National Research Council, 1977;Januszkiewicz et al. 1992;Januszkiewicz and Mayorga, 1993).…”

Section: Pathophysiologymentioning

confidence: 99%

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Overview of nitrogen dioxide effects on the lung with emphasis on military relevance

Mayorga¹

1994

Toxicology

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Pathophysiologic Responses of Sheep to Brief High-Level Nitrogen Dioxide Exposure

Cited by 8 publications

References 30 publications

Association of Mechanical Ventilation and Flue Use in Heaters With Asthma Symptoms in Japanese Schoolchildren: A Cross-Sectional Study in Sapporo, Japan

Association of Mechanical Ventilation and Flue Use in Heaters With Asthma Symptoms in Japanese Schoolchildren: A Cross-Sectional Study in Sapporo, Japan

The respiratory health effects of nitrogen dioxide in children with asthma

Overview of nitrogen dioxide effects on the lung with emphasis on military relevance

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