Pathophysiological Changes in Liver Tissues of Hypercalorie Diet-Induced Obese Rats

Abstract

Objectives: Hypercalorie diet intake has been associated with many long-term complications including metabolic syndrome, cardiovascular diseases, and nonalcoholic fatty liver disease.Methods: A total of 12 Wistar rats either sex were used in this study. These animals were randomly divided into two groups as control and obese rats. Group 1 consists of six rats weighing 150-200 g and fed with normal pellet chow. Another six rats were fed hypercalorie/cafeteria diet to induce obesity and included in the study after 19 weeks of age. All animals were sacrificed; liver tissues were collected, weighed and sent for the histopathological examination.Results: Weight of liver tissues of was significantly more in obese rats than the control rats. Histopathological examination shows an excessive fat deposition and sinusoidal congestion in the liver tissues of obese rats. Conclusion:Increase in body weight is associated with the increase in fat deposition in the liver tissues which further develops into inflammation and necrosis of liver cells.

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“… The high‐fat diet‐induced congestion and dilation of central veins and sinuses with simultaneous initiation of chronic inflammation in the portobiliary fields in the liver. Similar results were reported by Ambadasu et al, but the authors used a both fat‐ and carbohydrate‐rich diet (Ambadasu et al., 2016). We assume that the increase in dietary fat alone may have detrimental effects, even if it is not accompanied by body weight gain.…”

Russelioside B: a Pregnane Glycoside with Pharmacological Potential

“…Commercial products containing C. fimbriata extract are available in the international markets. The use of C. fimbriata extract (100 mg/kg/day) showed significant weight loss and improved lipid profile as compared with hypercaloric diet control group in rats, resulting in suppressing appetite and preventing fat accumulation (Ambadasu and DSWRW, 2013). This effect is due to inhibition the formation of enzymes responsible for fat synthesis (Naingade et al 2013).…”