Pathophysiology and Management of Cerebral Edema

Husna, Ully; Dalhar, Mochamad

doi:10.21776/ub.mnj.2017.003.02.7

Cited by 3 publications

(3 citation statements)

References 5 publications

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“…This indicates a shift in ion and water content between the extracellular and intracellular spaces, which is a characteristic feature of cytotoxic edema. However, the tissue does not swell or become heavier, and will not show ionic edema, vasogenic edema, or hemorrhagic conversion because there is no new source of water, ions, and blood (Husna et al, 2017).…”

Section: Discussionmentioning

confidence: 99%

Cerebral Histopathology in Acute Toxicity Test of Curcuma Zedoria

Lubis,

Wardhani,

Lubis

et al. 2023

jppipa, pendidikan ipa, fisika, biologi, kimia

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This research aims to determine the effect of the acute toxicity test of white turmeric extract (Curcuma zedoaria) on the brain organ. This research is experimental research with a Post Test Only Control Group Design. This research was conducted at the Pharmacy and Histology Laboratory. Faculty of Medicine. University of North Sumatra. The research was carried out from January to March 2023. The population in this research involved male white rats (Rattus norvegicus). The results of the acute toxicity test of white turmeric extract for 14 days showed no signs of toxicity or death in rats given the smallest to largest doses, resulting in an apparent LD50 value of white turmeric extract is >2 g/kgBW, and is classified in the practically non-toxic category. Rats that received white turmeric extract showed movement or activity, appearing more energetic by the end of the second week with increasing doses. Histopathological examination of the brain in the acute toxicity test revealed minimal changes, such as edema and congestion in line with increasing doses.

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Section: Discussionmentioning

confidence: 99%

Cerebral Histopathology in Acute Toxicity Test of Curcuma Zedoria

Lubis,

Wardhani,

Lubis

et al. 2023

jppipa, pendidikan ipa, fisika, biologi, kimia

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“…The recommended agent is dexamethasone [3]. Dexamethasone is preferred because of its very low mineralocorticoid activity, long half-life, and high potency [7]. Dexamethasone treats edema in tumors by decreasing the expression of Vascular Endothelial Growth Factor (VEGF) thereby improving blood brain barrier dysfunction [8].…”

Section: Introductionmentioning

confidence: 99%

The Effects of Administrated Dexamethasone on Neurologic Assessment in Neuro-oncology Scale in Patients with Intracranial Tumors

Sina

Arina

Nasution

2021

Open Access Maced J Med Sci

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BACKGROUND: In intracranial tumors, glucocorticoids are the main therapy to treat peritumoral edema. Neurologic Assessment in Neuro-Oncology (NANO) score is an instrument that can assess neurological function objectively and practically in patients with intracranial tumors. AIM: This study aims to determine the effect of dexamethasone administration on the NANO score of intracranial tumor patients. METHODS: This study was a pre-experimental study with a pre and post-test design at the H. Adam Malik General Hospital in Medan from March to September 2020. The study population was intracranial tumor patients. The research subject were 37 subjects taken consecutively. Treated with dexamethasone injection, then examined the NANO score before and after receiving dexamethasone injection on days 1, 2, and 3. Statistical analysis with Friedman test. RESULTS: Based on the demographic characteristics of the research subjects, the mean age was 53.29 ± 8.5 years. Most of the research subjects were male (54.1%) while female (45.9%). Most types of intracranial tumors were secondary tumors (59.5%) while primary tumors (40.5%). The significant effect of dexamethasone on NANO score in patients with intracranial tumors (p < 0.001). CONCLUSION: There is an effect of dexamethasone on the NANO score of patients with intracranial tumors.

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“…Pengirisan jaringan otak dan pembuatan slide dengan paraffin block dilakukan di Laboratorium Patologi Anatomi RSUD Dr. Soetomo. Tunel) dilakukan seperti yang telah dilaporkan sebelumnya olehChandra et al, Husna et al, dan Annis et al,(17,19). Slide diamati dibawah mikroskop cahaya dengan pembesaran 400x dan dilakukan penghitungan sel yang positif pada 10 lapang pandang dan dicari reratanya.…”

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Pengaruh Pemberian Ekstrak Propolis terhadap Ekspresi TLR4 dan Apoptosis pada Jaringan Otak Tikus Model Traumatic Brain Injury (TBI)

Prasetyo

Handono

Dalhar

2017

JKB

Self Cite

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Traumatic brain injury (TBI) merupakan cedera kepala yang sering terjadi pada populasi di seluruh dunia. Selama cedera kepala terjadi reaksi kaskade inflamasi yang dihubungkan dengan aktivasi TLR4. Propolis adalah produk lebah dengan kandungan flavonoid tinggi yang mempunyai efek antioksidan, anti inflamasi, proteksi DNA, neuroprotektan, dan immunomodulator. Kandungan propolis berupa Caffeic Acid Phenethyl Ester (CAPE) dapat menekan reperfusi iskemia, mencegah aktifasi TLR4, menghambat produksi sitokin proinflamasi dan menghambat produksi ROS pada level transkripsi melalui supresi aktivasi NFkB sehingga akan menghambat apoptosis. Penelitian ini bertujuan untuk menguji pengaruh pemberian ekstrak propolis dalam berbagai dosis pada ekspresi TLR4 dan apoptosis di jaringan otak tikus Rattus norvegicus model trauma kapitis. Metode yang digunakan dalam penelitian ini adalah imunohistokimia dan DNA terfragmentasi (TUNEL). Sampel dibagi menjadi 5 kelompok, yaitu: kelompok model trauma dan perlakuan propolis masing-masing dosis 50mg, 100mg, dan 200mg, kontrol positif dan kontrol negatif. Pada akhir penelitian, tikus dikorbankan dan dibuat preparat otak untuk menilai ekspresi TLR4 dan apoptosis. Berdasarkan hasil analisis statistik, didapatkan hubungan yang signifikan antara ekspresi TLR4 dan apoptosis sel otak tikus model traumatik dengan berbagai dosis propolis (p=0,000, r=-0,903, p=0,000, r=-0,907, Korelasi Pearson). Penelitian ini membuktikan bahwa propolis berpengaruh dalam penurunan ekspresi TLR4 dan apoptosis di sel otak tikus model trauma kapitis.

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Pathophysiology and Management of Cerebral Edema

Cited by 3 publications

References 5 publications

Cerebral Histopathology in Acute Toxicity Test of Curcuma Zedoria

Cerebral Histopathology in Acute Toxicity Test of Curcuma Zedoria

The Effects of Administrated Dexamethasone on Neurologic Assessment in Neuro-oncology Scale in Patients with Intracranial Tumors

Pengaruh Pemberian Ekstrak Propolis terhadap Ekspresi TLR4 dan Apoptosis pada Jaringan Otak Tikus Model Traumatic Brain Injury (TBI)

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