Pathophysiology of seroma in breast cancer

Kuroi, Katsumasa; Shimozuma, Kojiro; Taguchi, Tetsuya; Imai, Hirohisa; Yamashiro, Hiroyasu; Ohsumi, Shozo; Saito, Shinya

doi:10.2325/jbcs.12.288

Cited by 136 publications

(123 citation statements)

References 29 publications

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“…Another factor is the presence of metastatic lymph nodes (9,32,38,39). The number of metastatic lymph nodes remains controversial because some studies found significant seroma formation, and others showed an insignificant association, similar to our study (10, 11, 24-29).…”

Section: Discussionsupporting

confidence: 85%

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Factors that Affect Drain Indwelling Time after Breast Cancer Surgery

et al. 2016

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Objective:The most common procedure to prevent seroma formation, a common complication after breast and axillary surgery, is to use prophylactic surgical drains. Ongoing discussions continue regarding the ideal time for removing drains after surgical procedures. In this study, we aimed to investigate factors that affect drain indwelling time (DIT). Materials and Methods: From 2014 to 2015, a total of 91 consecutive patients with breast cancer were included in the study. The demographic characteristics of the patients, treatment methods, histopathologic features of the tumor, size of removed breast tissue (BS), tumor size (TS), number of totally removed lymph nodes (TLN), and metastatic lymph nodes (MLN), whether they had neoadjuvant chemotherapy, and the DIT were retrospectively recorded from the hospital database. Results: The mean age of the patients was 48.9 years, and the mean DIT was 4.8 days. The mean size of breast removed was 17.3 cm and tumor size was 4.7 cm, and the mean number of metastatic lymph nodes was 3.3, and mean total number of lymph nodes was 14.1. Patients who had neoadjuvant chemotherahpy had longer DIT. There was a positive correlation between the BS, TS, TLN, MLN, length of hospital stay, and DIT. Linear regresion analysis revealed that the BS, TLN, and history of neoadjuvant chemotherahpy were independent risk factors for DIT. Conclusion: DIT primarily depends on BS, TLN, and history of neoadjuvant chemotherahpy. A policy for the management of removing drains to prevent seroma formation should thus be individualized.

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Section: Discussionsupporting

confidence: 85%

“…Breast size is another important factor (9,32,38,39). Wide chest wall dissection influences seroma formation (14).…”

Section: Discussionmentioning

confidence: 99%

Factors that Affect Drain Indwelling Time after Breast Cancer Surgery

et al. 2016

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“…8 Age, tumor size, surgical technique, the use of electrocautery (EC), preoperative chemotherapy and many other factors may affect the seroma formation. [9][10][11] It is claimed that, the use of EC increases seroma formation due to the tissue ischemia. 12 PEAK PlasmaBlade (PB) (Peak surgical inc. CA,USA), is an electrosurgical device that uses radiofrequency energy in short pulses via an insulated cutting electrode, and creates an effective cutting edge while the blade stays near body temperature.…”

Section: Introductionmentioning

confidence: 99%

Comparison of Electrocautery and Plasmablade on Ischemia and Seroma Formation after Modified Radical Mastectomy for Locally Advanced Breast Cancer

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et al. 2017

Surgical Techniques Development

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The aim of this study was to compare postoperative drainage volumes and IMA levels in patients who underwent modified radical mastectomy (MRM) with using PlasmaBlade (PB) or electrocautery (EC). A total of 36 patients who underwent MRM with PB or EC in our clinic between August 2012 to February 2013 were enrolled. Number of removed and positive lymph nodes, duration of drainage and total drainage volume was recorded. Seroma formation after drain removal and number of aspirations were also recorded. Serum ischemia modified albümine (IMA) levels were analysed before surgery, 1 hour and 24 hour after surgery. In total, 36 patients were treated with MRM in the study period. Of the 36 patients, 16 underwent MRM with PB, and 20 underwent MRM with EC. The patients demographics were similar in both groups. The mean drainage volume and seroma formation were significantly higher in the PB group when compared with EC group (P<0.05). Number of aspirations due to the seroma were also high in PB group. The total aspiration volume of seroma was not different in both groups. IMA levels 24 hours after surgery in the PB group was significantly higher than EC group. There was no statistical significance between the groups for IMA levels at 1 st hour. PB is a monopolar energy device and is associated with increased levels of ischemia. This situation resulted with an increased volume of total axillary drainage and elevated risk of seroma formation.

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“…Латеральный кожный лоскут подшивают к бо-ковой поверхности передней грудной стенки (рис. 4,5). Рана послойно ушивается с оставлением активных дренажей (рис.…”

Section: материалы и методыunclassified

“…Лидирующая роль в развитии постмастэктомиче-ского синдрома принадлежит лимфорее [4,5], которая способствует формированию лимфоцеле, возникно-вению местных осложнений (краевой некроз, инфи-цирование), истощает больного и приводит к отсрочке адъювантной терапии, а также сопровождается более длительной госпитализацией и увеличением количе-ства амбулаторных посещений [6].…”

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