Pathway- and Cell-Specific Kappa-Opioid Receptor Modulation of Excitation-Inhibition Balance Differentially Gates D1 and D2 Accumbens Neuron Activity

Tejeda, Hugo A.; Wu, Jocelyn; Kornspun, Alana R.; Pignatelli, Marco; Kashtelyan, Vadim; Krashes, Michael J.; Lowell, Brad B.; Carlezon, William A.; Bonci, Antonello

doi:10.1016/j.neuron.2016.12.005

Cited by 137 publications

(172 citation statements)

References 65 publications

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“…Expression levels of opioid peptide genes prodynorphin ( Pdyn ) and preproenkephalin ( Penk ) are considered to reflect activity level of D1‐ and D2‐MSNs, respectively . We studied if Hdc KO mice have abnormal striatal mRNA levels of Pdyn and Penk following open field test.…”

Section: Resultsmentioning

confidence: 99%

“…Regulation of dynorphin and enkephalin gene expression by dopamine was shown in animals with lesioned nigrostriatal pathway and in pharmacological experiments with dopamine receptors antagonist/agonists . Dynorphin binds preferentially to kappa‐opioid receptors, which in turn regulates dopamine release, gates excitatory/inhibitory inputs to MSN and MSN activity itself …”

Section: Discussionmentioning

confidence: 99%

“…We found decreased dynorphin and enkephalin expression in the striatum of Hdc KO mice. Release of striatal opioids is activity dependent, therefore gene expression of these opioids may reflect activity level of D1‐ and D2‐MSNs . Decreased Pdyn and Penk expression may suggest decreased activity of MSN in Hdc KO mice due to overexpression of inhibitory Gi‐coupled GPCR Hrh3 .…”

Section: Discussionmentioning

confidence: 99%

“…We found significant negative correlation between striatal Pdyn level and dopamine turnover. It should be established if decreased striatal Pdyn expression indicates decreased dynorphin peptide release and if decreased dynorphin peptide release by D1‐MSN could result in increased release of dopamine due to lack of inhibitory effect of kappa‐opioid receptors, located on dopaminergic terminals …”

Section: Discussionmentioning

confidence: 99%

“…[42][43][44] Dynorphin binds preferentially to kappa-opioid receptors, which in turn regulates dopamine release, gates excitatory/inhibitory inputs to MSN and MSN activity itself. 25,45 There is a large body of evidence from in-vitro studies and in vivo studies on Hdc and Hrh3 KO mice that Hrh3 regulates striatal activity. 7,10,[46][47][48] In addition, Hrh1 and Hrh2 are also present on the soma of MSN and other striatal cells and could contribute to adjusting MSN level of activity.…”

Section: Histamine May Indirectly Modulate Dopamine Release Throughmentioning

confidence: 99%

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Abnormal behavior, striatal dopamine turnover and opioid peptide gene expression in histamine‐deficient mice

Abdurakhmanova

Semenova

Piepponen

et al. 2019

Genes Brain and Behavior

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Hypothalamic histaminergic neurons regulate a variety of homeostatic, metabolic and cognitive functions. Recent data have suggested a modulatory role of histamine and histamine receptors in shaping striatal activity and connected the histaminergic system to neuropsychiatric disorders. We characterized exploratory behavior and striatal neurotransmission in mice lacking the histamine producing enzyme histidine decarboxylase (Hdc). The mutant mice showed a distinct behavioral pattern during exploration of novel environment, specifically, increased frequency of rearing seated against the wall, jumping and head/body shakes. This behavioral phenotype was associated with decreased levels of striatal dopamine and serotonin and increased level of dopamine metabolite DOPAC. Gene expression levels of dynorphin and enkephalin, opioids released by medium spiny neurons of striatal direct and indirect pathways respectively, were lower in Hdc mutant mice than in control animals. A low dose of amphetamine led to similar behavioral and biochemical outcomes in both genotypes. Increased striatal dopamine turnover was observed in Hdc KO mice after treatment with dopamine precursor l‐Dopa. Overall, our study suggests a role for striatal dopamine and opioid peptides in formation of distinct behavioral phenotype of Hdc KO mice.

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Section: Resultsmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Section: Histamine May Indirectly Modulate Dopamine Release Throughmentioning

confidence: 99%

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Abnormal behavior, striatal dopamine turnover and opioid peptide gene expression in histamine‐deficient mice

Abdurakhmanova

Semenova

Piepponen

et al. 2019

Genes Brain and Behavior

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Developmental and Adult Striatal Patterning of Nociceptin Ligand Marks Striosomal Population With Direct Dopamine Projections

Hueske,

Stine,

Yoshida

et al. 2024

J of Comparative Neurology

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Circuit influences on the midbrain dopamine system are crucial to adaptive behavior and cognition. Recent developments in the study of neuropeptide systems have enabled high‐resolution investigations of the intersection of neuromodulatory signals with basal ganglia circuitry, identifying the nociceptin/orphanin FQ (N/OFQ) endogenous opioid peptide system as a prospective regulator of striatal dopamine signaling. Using a prepronociceptin‐Cre reporter mouse line, we characterized highly selective striosomal patterning of Pnoc mRNA expression in mouse dorsal striatum, reflecting the early developmental expression of Pnoc. In the ventral striatum, Pnoc expression in the nucleus accumbens core was grouped in clusters akin to the distribution found in striosomes. We found that PnoctdTomato reporter cells largely comprise a population of dopamine receptor D1 (Drd1) expressing medium spiny projection neurons localized in dorsal striosomes, known to be unique among striatal projection neurons for their direct innervation of midbrain dopamine neurons. These findings provide a new understanding of the intersection of the N/OFQ system among basal ganglia circuits with particular implications for developmental regulation or wiring of striato‐nigral circuits.

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Pain‐induced alterations in the dynorphinergic system within the mesocorticolimbic pathway: Implication for alcohol addiction

Lorente

Cuitavi

Hipólito

2020

J of Neuroscience Research

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The International Association for the Study of Pain (IASP) defines pain "as an unpleasant sensory and emotional experience associated with actual or potential tissue damage or described in terms of such damage" (IASP Task Force on Taxonomy, 1994). As an emotional experience, pain usually negatively impacts patients' daily lives, not only because of physical impairment but also because of the appearance of neuropsychiatric comorbidities such as depression, anxiety, or even addiction. Because of this complex situation, treating pain and its associated neuropsychiatric pathologies becomes a difficult task for the health-care personnel.Pain and reward are opposed responses processed by interconnected brain areas that keep an adequate cognitive and emotional function (i.e., anterior cingulate cortex, dorsal striatum, and amygdala). Furthermore, pain can modify reward processing by decreasing dopamine (DA) release in nucleus accumbens (NAc), which leads to anhedonia or a negative affect state (Elman, Borsook, & Volkow, 2013;Massaly et al., 2019). Thereby, pain can be an important factor affecting addiction, especially in people with a previous history of drug abuse. In fact, inflammatory pain produces mu opioid receptor (MOR) desensitization and/or a reduction in its levels in the mesocorticolimbic system (MCLS;Ozaki et al., 2002;Zubieta et al., 2001). Interestingly, rats presenting inflammatory pain needed higher doses of heroin to

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Pathway- and Cell-Specific Kappa-Opioid Receptor Modulation of Excitation-Inhibition Balance Differentially Gates D1 and D2 Accumbens Neuron Activity

Cited by 137 publications

References 65 publications

Abnormal behavior, striatal dopamine turnover and opioid peptide gene expression in histamine‐deficient mice

Abnormal behavior, striatal dopamine turnover and opioid peptide gene expression in histamine‐deficient mice

Developmental and Adult Striatal Patterning of Nociceptin Ligand Marks Striosomal Population With Direct Dopamine Projections

Pain‐induced alterations in the dynorphinergic system within the mesocorticolimbic pathway: Implication for alcohol addiction

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