Patient characteristics and severity of human rhinovirus infections in children

Abstract

HRV-C was the most prevalent species and on its own was associated with severe disease in children<3 years. The association between infection with HRV species and clinical presentation is complex and affected by many confounding factors.

Children under five years of age in senegal: A group highly exposed to respiratory viruses infections

“…Interestingly, in the present pediatric study about 59.7% of picornaviruses infection cases are related to low respiratory tract infections (LRTIs) although these viruses are usually related to mild URTI. These results underline a need for picornaviruses investigation during viral diagnosis of respiratory tract diseases in light of recently published data regarding the association of rhinoviruses especially with severe respiratory tract infections in children [37][38][39], and in asthma exacerbations [16,[40][41][42].…”

Molecular epidemiology of severe respiratory disease by human rhinoviruses and enteroviruses at a tertiary paediatric hospital in Barcelona, Spain

“…Significant differences between HRV-A and HRV-C were not found to be related to any of the patients' epidemiologic and clinical characteristics (Table 1). However, some series have shown that HRV-C could cause more severe disease in children younger than 3 years [6]. Respiratory viral codetections were found in four patients (two respiratory syncytial virus, one adenovirus, one human parainfluenza 3), which were not associated with either HRV species or severity, as reported previously [6].…”

“…Median PICU admission was 4 days (interquartile range 3.0-12.0 days). The most common HRV specie was HRV-C (18/35), followed by HRV-A (16/35), as reported by others [6]. Significant differences between HRV-A and HRV-C were not found to be related to any of the patients' epidemiologic and clinical characteristics (Table 1).…”

“…However, some series have shown that HRV-C could cause more severe disease in children younger than 3 years [6]. Respiratory viral codetections were found in four patients (two respiratory syncytial virus, one adenovirus, one human parainfluenza 3), which were not associated with either HRV species or severity, as reported previously [6]. Cultures of bronchoalveolar lavage were performed within the first 72 hours of admission in 11 patients who underwent invasive mechanical ventilation.…”

Longitudinal Study on Respiratory Viral Co-Infections in the Presence or Absence of Clinical Manifestation in Infants Aged 0&ndash;2 Years

“…Only HRV was detected in P4-6, corresponding to moderate clinical symptoms (Table 1). It has recently been shown that asymptomatic individuals often harbor HRV (12), and Lauinger et al also reported that the HRV genotype per se was not linked to the severity of clinical symptoms (13). Data from the present study also support the notion that HRV infection is common among the human population.…”