Pattern of colorectal cancer at two hospitals in the western region of Saudi Arabia

Abstract

Patients and Methods: Data of all patients with CRC treated at two hospitals in the Western region of the Kingdom of Saudi Arabia (KSA), between 1993 and 2002, were collected and analyzed. Results: Out of the 121 patients evaluated, ten were excluded because of incomplete data. Out of 111 patients, 59 (53.2%) were males, with a male to female ratio of 1.13: 1 and 49 (44.1 %) were Saudis. Thirty-three patients (29.7%) were 40 years or less and 78 (70.3%) were more than 40 years. Colon cancer was found in 69 patients (62.2%) and rectal cancer in 42 (37.8%). Stages at presentation were; stage 0 (2.7%), stage I (11.7%), stage 11 (23.4%), stage III (20.7%), stage IV (22.5%) and the staging was unknown in 18.9% of the patients. The most common tumor grade was moderately differentiated (38.7%), followed by poorly differentiated (20.7%) and well differentiated 19.8% of the patients. Forty-four patients (39.6%) were alive at the time of data collection, 43 (38.7%) expired and 24 (21.6%) were lost to follow up. Correlation between age groups revealed that young patients had more advanced stage and poorly differentiated tumors than > 40 years old (p= 0.005 and 0.024 respectively). Conclusion: Compared to data from Western countries, colorectal cancer in this population is more common in younger patients. It presents more commonly in a more advanced stage and poorly differentiated type than in older patients How to cite this article: Al-Ahwal MS, Al-Ghamdi AA. Pattern of colorectal cancer at two hospitals in the western region of Saudi Arabia. Saudi J Gastroenterol 2005;11:164-169

Pattern & presentation of colorectal cancer in central Sudan, a retrospective descriptive study, 2010-2012.

“…In this study males were more than females but the ratio was almost similar (1: 1.02) which can be compared to that shown by Verschueren RC et al 24 and other studies 10,25,26 . On the other hand Guraya S Y showed a different male to female ratio of (4: 1) Tumor grade pattern in our study was mainly well differentiated adenocarcinoma (45%) then poorly differentiated (26.67%), in a similar study in Saudi Arabia 25 moderately differentiated was the most common followed by poorly differentiated adenocarcinoma.…”

Does the Increasing Trend of Colorectal Cancer Incidence in Jeddah Reflect a Rise in the Kingdom of Saudi Arabia?

“…This finding concurs with a data analysis of 111 patients with CRC performed between 1993 and 2002 from two hospitals in the western region of KSA (Ministry of Health K, 2007) The authors reported that the mean age at diagnosis was 59 years in males and 56 years in females. In our study cohort, the incidence of CRC was higher in males than females, which is not only in line with reports from KSA but is also consistent with reports worldwide (Al-Ahwal, 2005).…”

“…The location of the disease in the colorectal area and its clinical features are also not very different from what has been described in the past (Isbister, 1992;2000;Mansoor, 2002;Al-Ahwal, 2005;Abdul, 2011).…”

“…Finally, the previous recommendations that have been suggested at a national level for initial screening to commence at age 50 years in individuals with an average risk and as early as the age of 10 years in those with familial adenomatous polyposis or in an individual's early twenties for hereditary non-polyposis CRC (Lynch syndrome) and colonoscopy annually after age of 35 years, would be of great benefit to the people of the western region (Mansoor, 2002;Al-Ahwal, 2005). The need of the hour is an organized national campaign that would target preventive measures such as CRC screening programs and public awareness and education while considering well described cultural barriers (Ravichandran, 2010;.…”

Colorectal Cancer in the Kingdom of Saudi Arabia: Need for Screening

“…Unfortunately, it is difficult to make relevant comparisons with most studies conducted in the Kingdom because the majority of the few studies that were conducted are hospital-based (AlRadi et al, 2000;Isbister et al, 2000;Ayyub et al, 2002;Al-Ahwal and Al-Ghamdi, 2005;Sibiani et al, 2011) and therefore do not reflect the trend of the disease among Saudis in the Kingdom. However, this striking trend does mirror similar recent reports from other countries Matsuda al., 2010;Matsuda et al, 2011).…”