Pattern of prevalence, risk factors and treatment outcomes among Egyptian patients with multidrug resistant tuberculosis

Ibrahim, Emad; Baess, Ayman Ibrahim; Messery, Mahmoud Aly Al

doi:10.1016/j.ejcdt.2016.11.002

Cited by 23 publications

(20 citation statements)

References 26 publications

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“…This coincides with the epidemiological picture of tuberculosis where males spend more number of hours outdoor exposure and more challenging and hazardous working environments. Also this came in accordance with (6) who reported that the percentage of MDR-TB among males was 75.9% and that of females was 24.1% in three different governorates in Egypt.…”

Section: Discussionsupporting

confidence: 90%

Characteristics of Multidrug Resistant Tuberculosis in Minia, Egypt

2020

MLU

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BackgroundTuberculosis (TB) is a disease of great antiquity and has almost certainly caused more suffering and death than any other infection. A total of 40 patients were registered with a diagnosis of MDR-TB during 2010-2018 in Minia. The majority of patients were from rural areas (27; 67.5%) and male (27; 67.5%). Emergence of MDR-TB has the potential to be a serious public health problem in that necessitates strengthened TB control and improved continuous monitoring of therapy.

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Section: Discussionsupporting

confidence: 90%

Characteristics of Multidrug Resistant Tuberculosis in Minia, Egypt

2020

MLU

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“…Besides, drug malabsorption in HIV infected patients can also lead to drug resistance and has been shown to result in treatment failure. This condition may lead to the accumulation of drug-resistant strains [ 38 ]. In general, the HIV epidemic serves as an amplifier of TB outbreaks by providing a reservoir of susceptible hosts [ 39 ], the collective effect may result in the increase and transmission of MDR-TB strains in the general population.…”

Section: Discussionmentioning

confidence: 99%

Molecular detection of multidrug resistance pattern and associated gene mutations in M. tuberculosis isolates from newly diagnosed pulmonary tuberculosis patients in Addis Ababa, Ethiopia

et al. 2020

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Introduction Multi-drug resistance is a major challenge in the control of tuberculosis. Despite newer modalities for diagnosis and treatment, people are still suffering from this disease. Understanding the common gene mutations conferring rifampicin and isoniazid resistance is crucial for the implementation of effective molecular tools at local and national levels. Hence, this study aimed to evaluate the molecular detection of rifampicin and isoniazid-resistant gene mutations in M . tuberculosis isolates in Addis Ababa, Ethiopia. Method Health Center-based cross-sectional study was conducted between January and September 2017 in Addis Ababa, Ethiopia. The collected sputum samples were processed for mycobacterial isolation and Region of difference 9 based polymerase chain reaction for species identification. To characterize the rifampicin and isoniazid-resistant M . tuberculosis isolates, a molecular genetic assay (GenoType MTBDR plus ) was used; the assay is based on DNA-STRIP technology. Result Culture positivity was confirmed in 82.6% (190/230) of smear-positive newly diagnosed pulmonary tuberculosis cases enrolled in the study. From 190 isolates 93.2% were sensitive for both rifampicin and isoniazid, and 6.8% of the isolates were resistant to at least one of the tested anti-TB drugs. Gene mutations were observed in all studied multidrug resistance-associated gene loci ( rpoB , katG , and inhA ). Two isolates exhibited heteroresistance, a mutated, as well as wild type sequences, were detected in the respective strains. MDR-TB case was observed in 1.1% (2/190) of the cases. All the MDR-TB cases were positive for HIV and found to have a history of prior hospital admission. Conclusion In our finding a relatively high prevalence of any drug resistance was observed and the overall prevalence of multidrug-resistant tuberculosis was 1.1%.The majority of drug-resistant isolates demonstrated common mutations. Heteroresistant strains were detected, signaling the existence of an M . tuberculosis population with variable responses to anti-tuberculosis drugs or of mixed infections.

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“…14 Drug resistance develops due to the inappropriate choice of drugs, irregular drug supplies, and factors related to patients such as poor adherence to treatment, imprisonment, and poor compliance with treatment. [15][16][17] Drug-resistant MTB can be controlled by identifying and effectively treating sputum smear-positive cases. Furthermore, prophylaxis and health education have an essential role in controlling the spread of MDR-TB.…”

Section: Introductionmentioning

confidence: 99%

Prevalence of Mycobacterium tuberculosis infection and rifampicin resistance among presumptive tuberculosis cases visiting tuberculosis clinic of Adare General Hospital, Southern Ethiopia

et al. 2021

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Objective: Multidrug-resistant Mycobacterium tuberculosis is a public health threat in resource-limited countries where it is easily disseminated and difficult to control. The aim of this study was to determine the prevalence of tuberculosis, rifampicin-resistant/multidrug-resistant Mycobacterium tuberculosis, and associated factors among presumptive tuberculosis cases attending the tuberculosis clinic of Adare General Hospital located in Hawassa city. Methods: A hospital-based cross-sectional study was conducted among 321 tuberculosis suspected patients from April to July 2018. Socio-demographic, environmental, and behavioral data were collected using a structured questionnaire. Sputum specimens were analyzed using GeneXpert. Data entry was made using Epi info version 7 and analyzed by SPSS version 20. Logistic regression models were used to determine the risk factors. A p-value less than 0.05 was taken as a cut point. Results: In this study, the prevalence of Mycobacterium tuberculosis was 98 (30.5%) with 95% confidence interval (25.5–35.8), and the prevalence of rifampicin-resistant/multidrug-resistant Mycobacterium tuberculosis among the 98 Mycobacterium tuberculosis confirmed cases was 4 (4.1%). The prevalence of rifampicin-resistant/multidrug-resistant Mycobacterium tuberculosis among the tuberculosis suspected patients was 1.24%. Participants who had a history of treatment with anti-tuberculosis drugs were more likely to develop rifampicin-resistant/multidrug-resistant Mycobacterium tuberculosis. Conclusions: This study identified relatively high rifampicin-resistant/multidrug-resistant Mycobacterium tuberculosis among tuberculosis suspected patients in the study area. Early detection of drug-resistant Mycobacterium tuberculosis should be given enough attention to strengthen the management of tuberculosis cases and improve direct observation therapy short-course and eventually minimize the spread of rifampicin-resistant tuberculosis strain in the community.

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Pattern of prevalence, risk factors and treatment outcomes among Egyptian patients with multidrug resistant tuberculosis

Cited by 23 publications

References 26 publications

Characteristics of Multidrug Resistant Tuberculosis in Minia, Egypt

Characteristics of Multidrug Resistant Tuberculosis in Minia, Egypt

Molecular detection of multidrug resistance pattern and associated gene mutations in M. tuberculosis isolates from newly diagnosed pulmonary tuberculosis patients in Addis Ababa, Ethiopia

Prevalence of Mycobacterium tuberculosis infection and rifampicin resistance among presumptive tuberculosis cases visiting tuberculosis clinic of Adare General Hospital, Southern Ethiopia

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