Pattern of Sinonasal Tumors in Eastern Nepal

Nepal, Ajit; Joshi, RR; Chettri, Shyam Thapa; Karki, Smriti

doi:10.3126/njenthns.v1i2.4755

Cited by 4 publications

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“…The predominance of female seen in this study is in contrast with the previous study conducted in our center that reported equal gender affectation 8 and other reports; 3 9 10 however, it is in agreement with a recent study conducted by Fasunla and Ogunkeyede 11 in Ibadan. In our environment, cooking is still being considered as women's job, and more than 55% of the patients in this study were exposed to wood dust most likely in the form of firewood for cooking, and unconfirmed report also showed that women present early to the hospital than male counterpart.…”

Section: Discussionsupporting

confidence: 88%

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Clinical presentation and outcome of sinonasal tumors in a Nigerian Tertiary Hospital – 6-year review

et al. 2017

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Background:Sinonasal tumor is an uncommon tumor in Nigeria, but the burden of the disease in terms of morbidity and mortality is on the increase. The aim of this study is to evaluate the pattern of presentation and outcome of sinonasal tumor in our center.Methodology:This was a retrospective review of all the patients with sinonasal cancer seen in Ear, Nose, and Throat Department of the hospital between January 2008 and December 2013. The patients' biodata, clinical presentation, stage of the disease at presentation, identifiable risk factors, histopathological findings, and outcome were presented.Results:A total of 22 patients were diagnosed with sinonasal cancer out of 71 patients (31%) with head/neck cancers during the period of study. There were 12 males (54.5%) and 10 females (45.5%) with a mean age of 51 ± 2.1 years. Epistaxis, nasal blockage, and discharge were seen in all patients though 41% of patients presented first to the ophthalmologist due to proptosis. Identifiable risk factors were exposure to wood dust (29%) and petrochemical products in (11%). Most patients presented first at advanced stages of the disease (82%). Histologically, well-differentiated squamous cell carcinoma was the most common (54.6%) followed by nonintestinal well-differentiated adenocarcinoma in 18.2% and plasmacytoma (9.1%). Chemoradiation was the mainstay of management in (38%) though 13.6% had total maxillectomy with postsurgical chemoradiation and 50.4% defaulted due to cost of management.Conclusion:Health education on early presentation and efforts at early detection of the disease are needed to achieve cure. Exposure to the identifiable risk factors should be reduced by protective measures. Easy access to radiotherapy at affordable price will surely improve the outcome of this disease.

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Section: Discussionsupporting

confidence: 88%

“…Furthermore, the involvement of females in similar occupation with their male counterparts for socioeconomic gain which exposed them to the risk factors of sinonasal tumors such as woodwork, leatherwork, and exposure to petrochemicals might also be a contributory factor to the increased female affectation. 9 10…”

Section: Discussionmentioning

confidence: 99%

Clinical presentation and outcome of sinonasal tumors in a Nigerian Tertiary Hospital – 6-year review

et al. 2017

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“…However; other studies have noted predominance of benign tumors over the malignant ones. [9][10][11] Since our study was based at cancer hospital where diagnosed malignant cases are referred for further management; it may have led to predominance of malignant ones.…”

Section: Discussionmentioning

confidence: 99%

Histopathological Pattern of Salivary Gland Tumors

et al. 2014

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Background: The tumors of the salivary glands are uncommon head and neck neoplasms. The aim of this study was to evaluate the relative frequencies, types, site distribution and the histopathological features of salivary gland tumors. Materials and Methods: This was a retrospective study of 176 cases of salivary gland tumors collected from medical record section and department of pathology at B.P.Koirala Memorial Cancer Hospital from Jan. 2005 to Dec. 2010. Tumors were analyzed based on demographics, anatomic location and histopathological type. Results: Out of 176 cases, 66 (37.5 %) were benign and 110 (62.5 %) were malignant with M:F ratio of 1.7:1. The mean age observed was 44.76 years with age range of 12 to 75 years. Pleomorphic adenoma was found to be the commonest benign tumor (72.7 %), followed by Warthin tumor (15.1%), monomorphic adenoma (3.0 %) and basal cell adenoma (3.0 %). The mucoepidermoid carcinoma was the most common malignant tumor (38.1 %), followed by adenoid cystic carcinoma (25.4%), acinic cell carcinoma (10.9%), adenocarcinoma NOS (6.3%), carcinoma ex pleomorphic adenoma (5.4%) and unclassified malignant tumor (4.5 %). Parotid was the most common site for the location of tumors (70.4%) followed by submandibular (19.3%) and minor salivary glands (10.2 %). Conclusion: Pleomorphic adenoma was the commonest salivary gland tumor observed in both sexes. Mucoepidermoid carcinoma was the most common malignant salivary gland tumor. The parotid gland was the most common site of origin in both benign and malignant tumors. DOI: http://dx.doi.org/10.3126/jpn.v4i7.10291 Journal of Pathology of Nepal (2014) Vol. 4, 520-524

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“…9 No data on incidence of melanoma in Nepal were available except for only a few reported cases of melanoma in vagina, eyes and nasal cavity. 7,10,11 In the study conducted by Nagore E et al in Spain, the total number of cases enrolled in the study was 1571 over a period of 18 years. 8 But in the study conducted by Hui S K et al in Hong Kong Chinese patients over a period of 12 years, the total number of cases was only 32.…”

Section: Discussionmentioning

confidence: 99%

Clinico-pathological Study of Malignant Melanoma in A Tertiary Care Centre

et al. 2017

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Introduction: Malignant melanoma, which causes three fourth of all deaths related to skin cancer, is more common in Caucasian population compared to Asian population. There is no reliable information about malignant melanoma in Nepal hence an effort has been made to assess the clinical and pathological features of melanoma patients. Methods: This was a retrospective hospital based study done in the department of Pathology. All cases of malignant melanoma diagnosed on biopsy during a period of 13 years were retrieved, reviewed and collated. Results: We had 35 cases with age range from 15 to 84 years with the mean of 51.4 years and M: F of 1.3:1. The predominant site was lower extremities. Most cases were less than 3 cm. Majority of histologic subtypes were nodular melanoma 29 (82.8%) followed by mucosal lentiginous melanoma 3 (8.6%), superficial spreading melanoma 2 (5.7%) and acral lentiginous melanoma 1 (2.9%). Half (50%) of the excisional biopsies were at Clark’s level IV and 75% were at high Breslow thickness. Conclusions: The most frequent site in males and females were lower extremities and trunk respectively in contrast to Western studies where it is opposite. Nodular melanoma was the commonest histologic subtype while in other Asian studies and in Western studies majority were acral lentiginous melanoma and superficial spreading melanoma respectively. Keywords: Breslow thickness; Clark’s level; malignant melanoma; nodular melanoma.

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Pattern of Sinonasal Tumors in Eastern Nepal

Abstract: Keywords: Carcinoma; maxillectomy, papilloma; sinonasal tumorDOI: 10.3126/njenthns.v1i2.4755 Nepalese J ENT Head Neck Surg Vol.1 No.2 (2010) p.9-11

Cited by 4 publications

References 0 publications

Clinical presentation and outcome of sinonasal tumors in a Nigerian Tertiary Hospital – 6-year review

Clinical presentation and outcome of sinonasal tumors in a Nigerian Tertiary Hospital – 6-year review

Histopathological Pattern of Salivary Gland Tumors

Clinico-pathological Study of Malignant Melanoma in A Tertiary Care Centre

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