Pattern of Visual Field Loss in Primary Angle-Closure Glaucoma Across Different Severity Levels

Atalay, Eray; Nongpiur, Monisha E.; Yap, Sae Cheong; Wong, Tina; Goh, David; Husain, Rahat; Perera, Shamira A.; Aung, Tin

doi:10.1016/j.ophtha.2016.05.026

Cited by 33 publications

(31 citation statements)

References 39 publications

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“…Cross-sectional studies comparing the total deviation values of the superior hemifield with that of the inferior hemifield at various stages (mild, moderate, and severe) of PACG reported greater total deviation values in the superior than in the inferior hemifield. 25,50 Verma et al 51 have shown that in early PACG, greater number of locations progressed in superior temporal Garway-Heath (GH) VF sector compared to inferior temporal GH VF sector. The reason for this discrepancy between Verma et al 51 and our study results may be due to the difference in the criteria for progression used in these studies.…”

Section: Discussionmentioning

confidence: 99%

Comparison of Visual Field Progression Rates Among the High Tension Glaucoma, Primary Angle Closure Glaucoma, and Normal Tension Glaucoma

Ganeshrao

Senthil

Choudhari

et al. 2019

Invest. Ophthalmol. Vis. Sci.

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PURPOSE. To compare the visual field (VF) progression among high tension glaucoma (HTG), primary angle closure glaucoma (PACG), and normal tension glaucoma (NTG) subjects in routine clinical care. METHODS. All patients had ‡5 VF tests using HFA, 24-2, SITA-standard strategy. We compared the progression between glaucoma subtypes after matching the VFs for baseline severity (mean deviation [MD]) and the age at presentation. Global VF progression was evaluated by linear regression analysis (LRA) of MD. For local VF progression, scotoma expansion (SE) defined as appearance of new scotoma and scotoma deepening (SD) defined by pointwise LRA were calculated. SE and SD were analyzed in three VF zones: superior arcuate (SA), inferior arcuate (IA), and central (C). RESULTS. A total of 310 HTG, 304 PACG, and 165 NTG eyes were included. When VFs were matched by baseline MD, a greater number (n ¼ 20/76) of eyes with HTG showed significant progression compared to PACG (n ¼ 9/76; P ¼ 0.04). The number of progressing eyes were not significantly different between HTG and NTG (n ¼ 11/76; P ¼ 0.10) and between NTG and PACG (P ¼ 0.65). When the baseline VFs were matched by age, the number of eyes showing significant progression were similar in all the subtypes. SA zone in HTG and NTG showed greater SE and SD compared to other zones (P < 0.05), whereas IA zone in PACG showed greater SE and SD compared to other zones (P < 0.05). CONCLUSIONS. In our cohort of treated primary glaucoma with matched baseline severity, a greater proportion of HTG eyes progressed faster compared to PACG. SA zone in HTG and NTG and IA zone in PACG showed greater VF progression.

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Section: Discussionmentioning

confidence: 99%

Comparison of Visual Field Progression Rates Among the High Tension Glaucoma, Primary Angle Closure Glaucoma, and Normal Tension Glaucoma

Ganeshrao

Senthil

Choudhari

et al. 2019

Invest. Ophthalmol. Vis. Sci.

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“…Patients were divided into three groups with different severity based on MD, i.e. mild (MD ≤ 6.00 dB), moderate (12 dB ≥ MD >6 dB) and severe (MD > 12 dB) [49, 50]. …”

Section: Methodsmentioning

confidence: 99%

The association between serum uric acid and glaucoma severity in primary angle closure glaucoma: a retrospective case-control study

Shao

Tang

et al. 2016

Oncotarget

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Uric acid (UA) is a major antioxidant molecule and has been hypothesized to have a protective effect on the central nervous system against oxidative damage. We prospectively investigated the serum concentration of UA in primary angle closure glaucoma (PACG), and explored the association between serum concentration of UA and the severity of PACG. Using a retrospective case-control study design, 886 PACG subjects and 994 control subjects who attended the Eye & ENT Hospital of Fudan University, were eligible for this study. Glaucoma severity was classified as mild (MD ≤ 6.00 dB), moderate (12 dB ≥ MD > 6 dB) and severe (MD > 12 dB) based on the MD (mean deviation). The levels of UA were significantly lower (p = 0.025) in PACG (0.286 ± 0.082 mmol/l) compared with control (0.295 ± 0.085 mmol/l). The mean serum UA levels were lowest in the severe group (0.281 ± 0.074 mmol/l) followed by moderate (0.282 ± 0.080 mmol/l) and mild (0.297 ± 0.090 mmol/l) with significant differences among the three groups (p = 0.032). In multivariate regression analysis, there was a significant negative correlation between UA level and vertical cup-disc ratio (B = −0.165, p = 0.035). Significantly lower serum UA concentration in PACG and its negative association with disease severity presented it as an important candidate in reaction to oxidative stress in glaucoma pathogenesis.

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“…For both POAG and PACG groups, longitudinal VFs were stratified into groups of six (first six VFs) to 10 visits (first 10 VFs). The entire VF was divided into 10 spatial regions by allocating five regions both in the superior and inferior hemifields following the Glaucoma Hemifield Test (GHT) 28,39 : central, paracentral, nasal, arcuate 1, and arcuate 2 regions (Fig. 1).…”

Section: Visual Fieldsmentioning

confidence: 99%

Rates of Visual Field Loss in Primary Open-Angle Glaucoma and Primary Angle-Closure Glaucoma: Asymmetric Patterns

Yousefi

Murata

Fujino

et al. 2018

Invest. Ophthalmol. Vis. Sci.

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The purpose of this study was to evaluate the rate of visual field (VF) loss in primary open-angle glaucoma (POAG) and primary angle-closure glaucoma (PACG). METHODS. Four hundred forty eyes of 282 patients with POAG (aged 53.4 6 12.0: mean 6 standard deviation, years) and 79 eyes of 49 patients with PACG (aged 62.7 6 9.0 years) with at least six or more reliable VF tests were studied. Point-wise, region-wise, and global rates of VF change were assessed for POAG and PACG eyes. Only the VF records prior to laser iridotomy or cataract surgery were included in PACG eyes. The global and superior-inferior asymmetric rates of VF loss were compared between POAG and PACG eyes. RESULTS. The mean total deviation (mTD) values at baseline were À6.4 6 5.7 dB in POAG patients and À6.4 6 7.3 dB in PACG patients. There was not a significant difference in the progression rates of mTD between POAG eyes (À0.23 6 0.38 dB/y) and PACG eyes (À0.29 6 0.45 dB/y). In POAG eyes, the VF progression rate was significantly asymmetric across the horizontal line; the central, paracentral, and peripheral arcuate 2 regions in the superior hemifield had a significantly faster rate of VF loss than their inferior counterparts. In contrast, this asymmetry was not observed in the rate of VF loss in PACG eyes. CONCLUSIONS. POAG eyes showed a faster rate of VF loss in the superior hemifield compared to in the inferior hemifield, particularly in central and paracentral regions. This difference was not observed in PACG eyes.

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Pattern of Visual Field Loss in Primary Angle-Closure Glaucoma Across Different Severity Levels

Cited by 33 publications

References 39 publications

Comparison of Visual Field Progression Rates Among the High Tension Glaucoma, Primary Angle Closure Glaucoma, and Normal Tension Glaucoma

Comparison of Visual Field Progression Rates Among the High Tension Glaucoma, Primary Angle Closure Glaucoma, and Normal Tension Glaucoma

The association between serum uric acid and glaucoma severity in primary angle closure glaucoma: a retrospective case-control study

Rates of Visual Field Loss in Primary Open-Angle Glaucoma and Primary Angle-Closure Glaucoma: Asymmetric Patterns

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