Aim: The objective of this study was to compare the physical properties (retention, surface roughness, and wear) of conventionally constructed (pressed) bioHPP removable partial denture (RPD) frameworks versus computer aided designed-computer manufactured (CAD/CAM) RPD frameworks. Materials and Methods: Over standardized epoxy resin cast models, twenty frameworks were fabricated and divided equally into two groups, group A received ten conventionally fabricated (pressed) bioHPP frameworks and group B received ten CAD/CAM milled frameworks. Each framework was subjected to insertion/ removal cycles by using universal testing machine, (360, 720, 1080, 1440, 2116 cycles) representing time intervals baseline, three, six, nine-and twelvemonths respectively, where retention, wear and surface roughness were measured before and after each time interval. Results: Group B(CAD/CAM) milled RPD frameworks results showed statistically significant difference with higher mean values than group A (pressed) RPD frameworks results in all measured parameters throughout all time intervals. Conclusion: Within the limitations of this study, it could be concluded that either with milled or pressed way of construction BioHPP remains a reliable material that could be used to construct a highly accurate RPD framework with acceptable physical properties.