Patterns and Emerging Mechanisms of the Angiogenic Switch during Tumorigenesis

Abstract

avascular site, the cornea of a rabbit eye (Gimbrone et al., 1972). The implants attracted new capillaries that Boston, Massachusetts 02115 ‡ Depts. of Surgery and Cell Biology grew in from the limbus to vascularize the expanding tumor mass. If the capillaries were physically prevented Harvard Medical School Boston, Massachusetts 02115 from reaching the implant or were inhibited from undergoing angiogenesis, tumor growth was dramatically impaired, restricting the tumor nodule to a diameter of approximately 0.4 mm. Subsequent experiments have

The Angiogenic Switch Molecule, Secreted FGF-Binding Protein, an Indicator of Early Stages of Pancreatic and Colorectal Adenocarcinoma

“…In a more complex picture, angiogenesis is the mechanism mediating the growth and remodeling of a capillary network (48,49). In the adult organism, angiogenesis is commonly restricted to conditions of tissue repair and remodeling (eg, during menstruation and mammary gland involution), and pathologic circumstances, such as wound repair, inflammation, and neoplastic growth where it plays a pivotal role (48,50).…”

“…Thus, activation of the angiogenic switch during early stages of tumor development suggests that regulation of the angiogenic process is likely to be a rate-limiting step in the progression from small lesion to extensive disease (49,63,64). Numerous pro-angiogenic factors involved in tumor-dependent angiogenesis have been described, including, among others, members of the vascular endothelial growth factor (VEGF) family, platelet-derived growth factor (PDGF), transforming growth factor-alpha and -beta (TGF-a and TGF-b), and members of fibroblast growth factor (FGF) family.…”

Dipalmitoylphosphatidic acid inhibits breast cancer growth by suppressing angiogenesis via inhibition of the CUX1/FGF1/HGF signalling pathway

“…Angiogenesis refers to the process by which cells sprout to form capillaries and neovasculature from pre‐existing mature endothelial cells of the blood vessels wall 1. An efficient supply of nutrients and oxygen via angiogenesis is necessary for tumour cell proliferation and helps tumour cells enter into the circulation and further metastasize to distant organs 2.…”

Fibroblast growth factor 2 regulates endothelial cell sensitivity to sunitinib

“…Tumour angiogenesis (the growth of new blood vessels into tumours) is a key driver of tumour progression and has received considerable attention as a therapeutic target (Hanahan and Folkman, 1996;Kerbel and Folkman, 2002;Ferrara and Kerbel, 2005). One of the most highly studied pro-angiogenic growth factors is vascular endothelial growth factor (VEGF), particularly the VEGF-A isoform, which is highly expressed in a variety of human tumours (Ellis and Hicklin, 2008).…”