Patterns of colonic dismotility and visceral hypersensitivity at various clinical variants of irritable bowel syndrome

Bubnova, Ye.A.; Fomenko, O. Yu.; Халиф, И. Л.; Pavlenko, V. V.

doi:10.22416/1382-4376-2016-6-32-39

Cited by 6 publications

(4 citation statements)

References 0 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…Показанием к обязательному проведению эрадикационной терапии инфекции H. pylori служит язвенная болезнь (ЯБ) желудка и двенадцатиперстной кишки в стадии обострения и ремиссии (УДД 1, УУР А) [1,13,14]. При осложненных формах ЯБ, в первую очередь при кровотечении, эрадикационная терапия должна быть проведена обязательно и начата при переводе больного на пероральный прием лекарственных средств (УДД 1, УУР А) [1,13].…”

Section: Discussionunclassified

“…Референсными методами диагностики инфекции H. pylori служат дыхательный тест с мочевиной, меченной 13 С, и определение антигена H. pylori в кале лабораторным способом (УДД 2, УУР В) [1,3,36]. В качестве метода первичной диагностики у лиц, у которых имеются показания к проведению эзофагогастродуоденоскопии, может быть использован быстрый уреазный тест с получением биоптата из антрального отдела и тела желудка (УДД 4, УУР С) [3,13,37,38].…”

Section: первичная диагностикаunclassified

“…Оценку необходимо осуществлять с помощью дыхательного теста с мочевиной, меченной 13 С, или определения антигена H. pylori в кале лабораторным способом не ранее чем через 4 нед дациях уверенно занимает место терапии первой линии, особенно в регионах с высокой резистентностью к кларитромицину [3,58]. По сути сочетанная терапия является стандартной тройной схемой, усиленной метронидазолом.…”

Section: оценка эффективности эрадикационной терапии инфекции H Pyloriunclassified

See 2 more Smart Citations

Diagnostics and treatment of Helicobacter pylori infection in adults: Clinical guidelines of the Russian gastroenterological association

Ивашкин¹,

Mayev²,

Лапина³

et al. 2018

Ross z gastroènterol gepatol koloproktol

View full text Add to dashboard Cite

Aim of publication. To present indications for antihelicobacter therapy, methods and sequence of diagnostics and eradication treatment of Helicobacter pylori (H. pylori) infection to general practitioners. Key points. Chronic gastritis caused by H. pylori infection, including that in «asymptomatic» patients can be considered to be an indication for H. pylori eradication therapy both as etiological treatment and opportunistic screening diagnostics for gastric cancer prevention. Indications for obligatory antihelicobacter therapy include stomach and a duodenum peptic ulcer (PU), stomach MALT-lymphoma, early gastric cancer with endoscopic resection. Breath test with 13 С-labeled urea, laboratory test for assessment of anti-H. pylori antibodies in feces, rapid urease test and serological method can be recommended for primary diagnostics of infection. Serological test is not applicable after antihelicobacter therapy. According to the bulk of regional studies clarithromycin resistance level of H. pylori strains in Russia does not exceed 15%. Obtained data indicate the absence of high metronidazole-resistance of H. pylori as well as double resistance to clarithromycin and metronidazole. Standard triple therapy including proton pump inhibitor (PPI), clarithromycin and amoxicillin is recommended Цель публикации. Ознакомить практикующих врачей с показаниями к проведению антигеликобактерной терапии, методами и порядком проведения диагностики и эрадикационной терапии инфекции Helicobacter pylori (H. pylori). Основные положения. Хронический гастрит, вызванный инфекцией Н. pylori, в том числе у «бессимптомных» лиц, можно рассматривать как показание к проведению эрадикационной терапии инфекции Н. pylori в качестве этиотропного лечения и оппортунистического скрининга для профилактики рака желудка. Показаниями к обязательному проведению антигеликобактерной терапии служат язвенная болезнь желудка и двенадцатиперстной кишки, MALT-лимфома желудка, ранний рак желудка с эндоскопической резекцией. В качестве методов первичной диагностики инфекции H. pylori используют дыхательный тест с мочевиной, меченной 13 С, определение антигена H. pylori в кале лабораторным способом, быстрый уреазный тест и серологический метод. После проведения антигеликобактерной терапии серологический метод не применяют. Согласно результатам большинства региональных исследований, показатели устойчивости штаммов H. pylori к кларитромицину в России не выше

show abstract

Section: Discussionunclassified

Section: первичная диагностикаunclassified

Section: оценка эффективности эрадикационной терапии инфекции H Pyloriunclassified

See 1 more Smart Citation

Diagnostics and treatment of Helicobacter pylori infection in adults: Clinical guidelines of the Russian gastroenterological association

Ивашкин¹,

Mayev²,

Лапина³

et al. 2018

Ross z gastroènterol gepatol koloproktol

View full text Add to dashboard Cite

show abstract

“…В проспективное когортное исследование были включены 32 пациента без клинических проявлений ишемической болезни сердца (ИБС) c установленным диагнозом ВДСУ и часто рецидивирующей пароксизмальной формой ФП. Из них основную группу составили 17 пациентов, которые в течение 6 нед от момента первичного аритмологического приема принимали пантопразол в дозе 20 мг 2 р/сут по поводу диагностированных эрозий двенадцатиперстной кишки [12]. Остальным 15 пациентам (группа контроля) не были назначены ИПП ввиду отсутствия эрозивно-язвенного поражения желудочно-кишечного тракта.…”

Section: материал и методыunclassified

Study of the Effect of Proton Pump Inhibitors on the Development of Hypomagnesemia in Patients with Paroxysmal Atrial Fibrillation on the Background of Autonomic Sinus Node Dysfunction

Bozhko

Архипов

Belokonova

2020

Racionalʹnaâ farmakoterapiâ v kardiologii

View full text Add to dashboard Cite

Aim. To study the effect of proton pump inhibitors (PPIs) on the development of hypomagnesemia in patients with paroxysmal atrial fibrillation (AF) on the background of autonomic sinus node dysfunction (ASND).Material and methods. A prospective cohort study included 32 patients with an established diagnosis of ASND and often recurrent paroxysmal AF. The main group consisted of 17 patients who took pantoprazole at a dose of 20 mg 2 times a day as treatment of diagnosed duodenal erosions within 6 weeks from the time of the initial visit to an arrhythmologist. The remaining 15 patients did not take PPIs and were included in the control group. The determination of magnesium in whole blood, plasma and formed elements was carried out twice in all patients – at the initial visit and after 6 weeks. In addition, in the experiment, complex-forming activity of solutions of various PPIs (esomeprazole, pantoprazole, rabeprazole and omeprazole) with respect to magnesium ions was studied. The author’s method was used, based on turbidimitric determination of the light transmission during the heterogeneous reaction of the formation of magnesium phosphates in the presence of the analyzed drug or without it.Results. There were no significant differences in the magnesium content in the blood of patients of the main and control groups before taking PPIs. After taking of pantoprazole by the patients of the main group there were significant differences between main and control groups in magnesium in whole blood (0.48 [0.44-0.51] mmol/l vs 0.55 [0.5-0.61] mmol/l, p=0.01) and its values in formed elements (0.52 [0.45-0.67] mmol/l vs 0.75 [0.65-1.2] mmol/l, p=0.009). Analysis of magnesium content in patients of the main group before and after taking of pantoprazole also showed a significant decrease in intracellular concentrations of the element (0.6 [0.51-1.0] mmol/l vs 0.52 [0.45-0.67] mmol/l, p=0.002), as well as decrease in its total content in whole blood (0.51 [0.45-0.59] mmol/l vs 0.48 [0.44-0.51] mmol/l, p=0.04). To substantiate the observed effects it was experimentally proved the possibility of formation of strong complex compounds between the ions of magnesium and PPIs: the highest activity was demonstrated by rabeprazole and pantoprazole (coefficients of complex formation per unit of total organic carbon – 1.5 and 0.72, respectively) and the lowest – omeprazole and esomeprazole (0.04 and 0.09, respectively).Conclusion. A decrease of magnesium content in whole blood and formed elements in patients with paroxysmal AF on the background of ADSN was mediated by a six-week intake of pantoprazole in a dose of 20 mg 2 times a day for the treatment of concomitant erosion of the duodenum. When choosing PPIs for arrhythmological patients with concomitant gastro-duodenal pathology, it is advisable to be guided by the complexing activity of drugs with respect to magnesium ions: the most pronounced metal-ligand interaction with magnesium was shown by rabeprazole and pantoprazole, and the least – omeprazole and esomeprazole.

show abstract

The modern ideas about the etiology of irritable bowel syndrome

2019

View full text Add to dashboard Cite

This article is devoted to the theme of the etiology of irritable bowel syndrome. This topic is highlighted in comparison with the Roman diagnostic criteria of III and IV revision. The following is considered: the theory of disturbed interaction within the «brain-gut» axis and visceral hypersensitivity induced in this way, as well as a possible mechanism for its implementation; also, the relationship of symptoms of IBS with patients’ mental state: anxiety, depression, sleep disorders. The relationship of IBS with microbiota of the intestine, the genetic mediation of IBS, the examples of candidate genes in biomarkers; the mechanisms of work of these genes are also described; the issue of intolerance to certain foods (FODMAPs, IgE-mediated hypersensitivity) in patients with IBS is highlighted as well; immunological aspects, including the theory of subclinical inflammation (low-grade inflammation) or post-infection IBS.

show abstract

Patterns of colonic dismotility and visceral hypersensitivity at various clinical variants of irritable bowel syndrome

Cited by 6 publications

References 0 publications

Diagnostics and treatment of Helicobacter pylori infection in adults: Clinical guidelines of the Russian gastroenterological association

Diagnostics and treatment of Helicobacter pylori infection in adults: Clinical guidelines of the Russian gastroenterological association

Study of the Effect of Proton Pump Inhibitors on the Development of Hypomagnesemia in Patients with Paroxysmal Atrial Fibrillation on the Background of Autonomic Sinus Node Dysfunction

The modern ideas about the etiology of irritable bowel syndrome

Contact Info

Product

Resources

About