Background. A comparative study of the dynamics of iodine desorption from drugs containing iodoform and used after tooth extraction to preserve blood clots and prevention, treatment of inflammatory complications. This took into account the type and form of drugs. The content and desorption of iodine determine the duration of local exposure to the drug on the tissues of the tooth well. Objectives. To study the physico-chemical properties of iodoform containing topical preparations for the prevention and treatment of alveolitis of the jaw. Methods. The objects of the study were complex multicomponent preparations of domestic production, presented in the dental market in the form of gauze bandage, collagen sponge, paste, powder containing iodoform. A standard titrimetric method was used to quantify the iodine content in aqueous systems. For the analysis of changes of iodine content in aqueous model systems applied to the spectrophotometric method in which the concentration of a substance was assessed according to the calibration chart from 0 minutes to 48 hours. In the model solution, the albumin and pH were changed, iodine concentration was determined in 1, 15 and 30 min. Results. Medications significantly differed in both the number of iodoform and desorption in the aquatic environment of the iodine. However, the content of iodoform in the preparations did not exceed the maximum permissible concentration. Desorption of iodine from the bandage after 15 minutes is significantly less than from the viscose flagellum. Desorption of iodine from the collagen sponge remains constant for 24 hours., but increases after 48 hours. Desorption of iodine from the powder is reduced after 45 minutes. Desorption of iodine from the paste gradually increases, reaches a maximum of 105 minutes and persists after 48 hours. In the albumin-bound state, iodine is more easily desorbed in an acidic medium, and at low concentrations of iodine, desorption in a neutral medium is significantly less. Conclusions. The duration of action of iodoform when applied topically affect the dosage form of the carrier (fiber, sponge, paste, powder), the concentration of the drug, the pH and albumin content in the aqueous medium.

Aim. To determine magnesium deficiency in patients with paroxysmal atrial fibrillation using a comprehensive clinical and laboratory approach. Methods. The prospective cohort study included 35 patients of the cardiology department of the Medical association «Novaya bolnitsa». The main group consisted of 22 patients with frequently recurrent paroxysmal atrial fibrillation, the control group - 13 patients without cardiac arrhythmias. The clinical status, Holter-monitoring of the electrocardiogram, the results of the clinical test for magnesium deficiency, laboratory parameters of calcium, magnesium in blood plasma and formed elements, magnesium in whole blood, free fatty acids and plasma osmolarity were evaluated. Results. The clinical score of magnesium deficiency was significantly higher in patients from the main group compared to the control [16.5 (11÷21) vs 13 (8÷15), p <0.001]. In the main group, there was a decrease of magnesium in the whole blood [0.55 (0.5÷0.59) vs 0.61 (0.58÷0.54), p=0.002] and inside the blood cells [0.68 (0.53÷1.29) vs 1.38 (1.29÷1.44), p <0.001]. In patients with atrial fibrillation there is a shift of the ratio of calcium to magnesium in blood plasma [2.5 (2.5÷3) vs 2.9 (2.8÷3.15), p=0.029] and intracellularly [4.85 (2.62÷9.3) vs 1.7 (1.4÷1.95), p=0.002]. The redistribution of calcium and magnesium is influenced not only by the initial concentration of cations, but also by free fatty acids. The best redistribution was obtained when the concentration of free fatty acids was 900 µmol/l, magnesium 1 mmol/l, and calcium 3 mmol/l, which is consistent with the optimal value of cations in the blood plasma. Conclusion. Patients with paroxysmal atrial fibrillation had a significantly lower magnesium content in whole blood and inside the blood cells; magnesium concentration in the cells and in whole blood closely correlated with the results of the clinical test for evaluating magnesium deficiency; intracellular magnesium content can be influenced by the complexing interaction with free fatty acids.

Senile xerosis is one of the most common pathology in elderly patients. The article presents an overview of current knowledge on the subject of skin barrier function and pathophysiological mechanisms and clinical features of senile xerosis. The corneotherapeutic approach to treatment of senile xerosis is substantiated and the effectiveness of emollients for baths was justified. The pH of water various sources (tap and artesian water) has alkaline values, which leads to an increase in dry skin and worsening clinical symptoms of xerosis. The effectiveness of bath emollients was investigated. The analysis of the adsorption properties of bath emollients was conducted which showed that these properties depend on pH of water. Hydrotherapy with using the citrate buffer system increases the efficiency of treatment. 60 women, aged 75-84 years, diagnosed with senile xerosis were treated with hydrotherapy containing citrate buffer system, bath emollient (shower oil). A clinical assessment was performed at the beginning and end of the study by a dermatologist using the Overall Dry Skin Scale (ODS) and Dermatological Life Quality Index (DLQI). Hydrotherapy with using a citrate buffer system provided a significant softening of the skin, elimination of scaling, remission of pruritus and more rapid clinical effect.

АннотацияЖители экологически неблагоприятных районов находятся под влиянием техногенных факторов. Вредные химические вещества поступают в организм из воздуха, питьевой воды, продуктов питания и обнаруживаются в ротовой жидкости, твердых тканях зуба, зубных отложениях, биоптатах тканевых структур и способствуют развитию кариеса и воспалительных заболеваний пародонта. Для профилактики основных стоматологических заболеваний применяются зубные пасты и ополаскиватели. В составе зубных паст содержатся различные абразивы: диоксид кремния, карбонат кальция, диоксид титана, гидрокарбонат кальция, гидроксиапатит, которые могут выступать в роли адсорбентов соединений тяжелых металлов. Биомониторинг с использованием метода масс-спектрометрии с индуктивно связанной плазмой (ИСП-МС) позволяет определять микроколичество металлов в ротовой жидкости. Исследование средств индивидуальной гигиены полости рта показали, что зубные пасты и ополаскиватели, применяемые пациентами для профилактики и лечения воспалительных заболеваний пародонта, имеют адсорбционную активность в отношении ионов металлов. В статье проведена оценка адсорбционной эффективности лечебно-профилактической зубной пасты относительно ионов металлов (хрома, марганца, кадмия, свинца и др.) в ротовой жидкости у жителей экологически неблагоприятных районов. Применение адсорбционно эффективной зубной пасты, содержащей оксиды кремния и титана, дважды в день на протяжении двух недель показало достоверное снижение концентрации ионов марганца, хрома, мышьяка, свинца и кадмия в смешанной слюне жителей, которые находятся под влиянием неблагоприятных экологических факторов. Современный метод ИСП-МС целесообразно использовать для высокоточного мониторинга ионного состава ротовой жидкости пациентов, проживающих в экологически неблагоприятных районах.Ключевые слова: зубная паста, ополаскиватель для полости рта, адсорбционная эффективность, мониторинг, оксид кремния Авторы заявляют об отсутствии конфликта интересов. The authors declare no conflict of interest.