Comparative Characteristics of Physico-Chemical Properties of Drugs Topical Application for the Prevention of Complications of Tooth Extraction

Kostina, Irina; Молвинских, Вера; Belokonova, N. A.; Огнев, Михаил; Ognev, Mihail

doi:10.18481/2077-7566-2018-14-4-64-70

Cited by 4 publications

(2 citation statements)

References 14 publications

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“…Орофациальные инфекции составляют значительную часть заболеваний на амбулаторном хирургическом стоматологическом приеме, при этом лидирующую позицию занимает апикальный периодонтит. Данная болезнь -основная причина удаления зубов у детей и взрослых [4][5][6]8].…”

Section: Introductionunclassified

“…В течение 7-10 суток после операции лунка зуба эпителизируется. Использование лекарственных средств для стабилизации кровяного сгустка в лунке удаленного зуба создает наиболее благоприятные условия для заживления раны в полости рта и профилактики послеоперационных осложнений [4].…”

Section: Introductionunclassified

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Local application of collagen sponge Alvokon after tooth extraction surgery

Kostina

Огнев

2023

Medicinskij alfavit

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After tooth extraction, it is necessary to create favorable conditions for the healing of the hole of the removed tooth. Dynamic observation of the patient by the attending physician is generally accepted to assess the condition of the postoperative wound and the patient’s implementation of recommendations for oral care. However, patients often note the presence of pain and swelling of the mucous membrane of the well of the removed tooth.Stude – a comparative assessment of the course of the early postoperative period in patients with local application of collagen sponges Alvokon and Alvostaz.Materials and methods. A prospective randomized study of 80 patients aged 20 to 59 years was conducted. The patients underwent a tooth extraction operation under local anesthesia. The patients were divided into 4 groups of 20 people. In patients of the first group, a collagen sponge Alvocon No. 3 was placed in the hole of the removed tooth, in patients of the second group – a collagen sponge Alvocon No. 5 in patients of the third group – a hemostatic collagen sponge «Alvostaz». Local medicines were not used in patients of the fourth group after tooth extraction. In the postoperative period, the presence of pain and the condition of the hole of the removed tooth were assessed.Results. Wound healing proceeded by secondary tension without complications in all patients. Comparing the nature of the course of the early postoperative period, pain after tooth extraction in patients of different groups varied from 5 to 50% of cases, and the presence of edema of the wound edges – from 5 to 100% of cases.Conclusions. Pain in the early postoperative period is expressed 2 times less when using the collagen sponge Alvokon No. 5. Edema of the marginal gum of the well of the removed tooth was 1.1 times less when using the collagen sponge Alvokon, 1.2 times when using the hemostatic collagen sponge Alvostaz in comparison with the group of patients without the use of a sponge.

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Local application of collagen sponge Alvokon after tooth extraction surgery

Kostina

Огнев

2023

Medicinskij alfavit

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Clinical effectiveness of a new collagen-based drug with lincomycin for the prevention and treatment of jaw alveolitis

Тарасенко

Muravev

Khurkhurov

et al. 2022

Russian Journal of Dentistry

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BACKGROUND: Alveolitis is the most common complication that occurs after tooth extraction. Among preventive and therapeutic methods, pharmacological agents for the dry socket treatment have been proposed. However, the gold standard for the prevention and treatment of alveolitis has not been defined. AIM: The study aimed to conduct a comparative analysis of the effectiveness of a collagen sponge with lincomycin and an iodoform tampon for the prevention of the development and treatment of alveolitis. MATERIAL AND METHODS: The study included 75 patients with jaw alveolitis and patients with teething disorders and chronic periodontitis who underwent planned tooth extraction. The patients were divided into two groups: group 1 underwent a socket revision, whereas group 2 had a tooth extraction. The patients of each group were divided into two subgroups: subgroup A used a collagen sponge with lincomycin and subgroup B used an iodoform tampon. The intensity of pain syndrome, severity of mucosal hyperemia, and collateral edema were assessed, and the epithelialization time of the sockets was recorded. RESULTS: The clinical study of the effectiveness of a collagen sponge with lincomycin in comparison with an iodoform tampon demonstrated some advantages of a collagen sponge, including a more comfortable postoperative period, mild pain, less pronounced edema and hyperemia, epithelialization of the extracted teeth sockets 1.5 days earlier. CONCLUSION: For the prevention and treatment of alveolitis, especially in patients in whom the use of iodine compounds is contraindicated, the use of Alvanes collagen sponge with lincomycin is preferable to an iodoform tampon.

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Evaluation of clinical, microbiological and immunological effectiveness of a collagen sponge with antimicrobial and immunotropic properties

et al. 2022

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Relevance. The etiology of alveolitis distinguishes infectious and traumatic factors, which determine the relevant drugs for preventing the inflammatory process after tooth extraction and local treatment of the developed alveolitis. Purpose – the study aimed to evaluate the effectiveness of a collagen sponge containing lincomycin hydrochloride compared to the traditional method using iodoform packing strips based on clinical, microbiological and immunological research methods.Materials and methods. The study examined and surgically treated 75 patients with jaw alveolitis (K10.3), including those with eruption disorders, chronic periodontitis and chronic periodontitis in remission. Routine tooth extraction was recommended for them. We treated developed alveolitis in 37 patients and prevented complications during tooth extraction in 38 patients. According to the local exposure, the study allocated two subgroups: A –collagen sponge containing lincomycin hydrochloride and B –iodoform packing strips (traditional method). We comparatively analyzed microbiological parameters and cytokine content in the mixed saliva of patients using enzyme immunoassay (EIA).Results. In the studied alveolar socket material with a confirmed diagnosis of alveolitis, a spectrum of priority pathogens was established, including mainly microaerophilic streptococci, obligate anaerobes and staphylococci. The monitoring of the local treatment method effectiveness demonstrated that the sponge with lincomycin does not fall behind in the decontamination level regarding streptococci and obligate anaerobes but is less effective against the staphylococcal component of the microbial consortium. Analysis of cytokines confirmed the presence of the immunotropic effect of the collagen sponge with lincomycin.Conclusion. The possibility of using a collagen sponge with lincomycin hydrochloride has been substantiated as an alternative method of local treatment of alveolitis, which has a pronounced antibacterial and immunotropic effect at the level of regulation of the cytokine status.

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Comparative Characteristics of Physico-Chemical Properties of Drugs Topical Application for the Prevention of Complications of Tooth Extraction

Cited by 4 publications

References 14 publications

Local application of collagen sponge Alvokon after tooth extraction surgery

Local application of collagen sponge Alvokon after tooth extraction surgery

Clinical effectiveness of a new collagen-based drug with lincomycin for the prevention and treatment of jaw alveolitis

Evaluation of clinical, microbiological and immunological effectiveness of a collagen sponge with antimicrobial and immunotropic properties

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