PCNA, Ki-67 and p53 expressions in submandibular salivary gland tumours

Alves, Fábio Abreu; Pires, Fábio Ramôa; Almeida, Oslei Paes de; Lopes, Márcio Ajudarte; Kowalski, Luiz Paulo

doi:10.1016/j.ijom.2004.01.010

Cited by 62 publications

(58 citation statements)

References 24 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…In the study conducted by Alves frequency of Ki-67 expression in 53.3% mucoepi dermoid carcinoma and 40% of adenoid cystic carcinoma were reported as negative (Alves et al, 2004). In our study 11% and 16%, of muco epidermoid carcinoma and adenoid cystic carcinoma were respectively negative for this marker.…”

Section: Discussionsupporting

confidence: 48%

Expression of Ki67 and CD105 as Proliferation and Angiogenesis Markers in Salivary Gland Tumors

Andisheh-Tadbir¹,

Pardis²,

Ashkavandi³

et al. 2012

Asian Pacific Journal of Cancer Prevention

View full text Add to dashboard Cite

Objective: To investigate the association between CD105 and tumor cell proliferation in salivary gland tumors. Methods: In this study, 59 samples of salivary tumors from Khalili Hospital archive, including 20 cases of pleomorphic adenoma (PA), 20 cases of mucoepidermoid carcinoma (MEC) and 19 cases of adenoid cystic carcinoma, as well as 10 cases of normal salivary gland tissue, were reviewed by immunohistochemistry (IHC) for CD105 and Ki67 staining. Results: CD105 positive vessels were absent in normal salivary gland tissue in the vicinity of tumors (51.6% of all tumors were positive). There was a statistically significant difference in frequency of CD105 staining between PA and malignant tumors and between four groups of different lesions (p<0.000) being highest in MEC. Intratumoral microvessel density was also elevated in malignant neoplasms (2.61±3.1) as compared to PA (0.46±0.6). Normal salivary glands did not express Ki67. There was a statistically significant difference in frequency and percentage of Ki67 immunoreactivity in malignant neoplasms (86.5% and 10.7±10.8 respectively) compared to PA (50% and 0.78±0.2) and among the four groups values were highest in MEC (p<0.000). Conclusion: n this study, it was observed a higher rate of angiogenesis and cellular proliferation was noted in malignant tumors compared to benign tumors, but no correlation was observed between these two markers.

show abstract

Section: Discussionsupporting

confidence: 48%

Expression of Ki67 and CD105 as Proliferation and Angiogenesis Markers in Salivary Gland Tumors

Andisheh-Tadbir¹,

Pardis²,

Ashkavandi³

et al. 2012

Asian Pacific Journal of Cancer Prevention

View full text Add to dashboard Cite

show abstract

“…12 Its therefore has the potential to be a more sensitive biomarker for cellular proliferation than mitoses. 13 The expression of Ki-67 has been correlated with mitotic activity, histological grade and clinical behavior of tumor and they found Ki67 proliferation marker has been absent 14 or had lowpositivity 15 in PAs. The aim of this study was to evaluate the expression of the proliferation marker Ki-67 in benign mixed salivary gland tumors in relation to age, sex, primary anatomical site, duration, size of the lesion, and the histological subtype of the tumor using a quantitative approach, and apply these data for further understanding of proliferative peculiarities, pathological characteristics and clinical behavior of this neoplasm.…”

Section: Introductionmentioning

confidence: 98%

Proliferative potential in benign mixed salivary gland tumors, using Ki67 marker in relation to different clinicopathological parameters

Muhammad

Mousa

Abdulqadir

2016

ZJMS

View full text Add to dashboard Cite

7Histologically a wide variety of structures may be seen. These varied tissues are Background and objective: Pleomorphic adenoma is the most common benign tumor of the salivary gland. It shows a remarkable degree of morphological diversity. Immunohistochemical Ki67 expression is used to predict the proliferative potential of the growth. The aim of this study was to evaluate the expression of the proliferation marker Ki-67 in benign mixed salivary gland tumors. Methods: Fifty five paraffin embedded tissue blocks were included in the study. After histopathological reassessment of hematoxylin and eosin stained section for each block, an immunohistochemical staining was performed using anti-Ki67 protein.Results: From total number of 55 cases, 58.1% of patients were in group aged ≤ 40 years. The male to female ratio was 1.037:1. The parotid gland was the most affected (56.37%) gland. The mean duration of lesions before treatment was 17.96 months and the mean size of tumors was 3.76 cm. Histologically, cell-rich subtype constituted 54.54%, followed by stroma-rich (34.55%), and only 10.91% of cases were classic. Ki67 expression was positive in 18.18% predominantly in epithelial variant with a weak score in nine cases (16.36%). Six of positive cases were in parotid gland and two cases in the submandibular gland. Only one case was in minor salivary gland. Moderate Ki67 expression score was seen in one epithelial variant case (14.28 %) associated with parotid gland. Conclusion: Immunohistochemical expression of Ki-67 in pleomorphic adenoma was characterized by low proliferative rate and predominantly seen in epithelial tumor variants.

show abstract

“…Expression of the P53 protein increased in malignant salivary gland tumors (12)(13)(14) and was correlated with poor differentiation, high degrees of malignancy, and poor prognosis (15). The mutation rate of the P53 gene varies in oral and maxillofacial tumors (12). Studies suggest that the conformation change of mutant P53 facilitates malignant cells escaping from regulation and immortalization.…”

Section: Discussionmentioning

confidence: 99%

Expression and clinical implications of P53, P63, and P73 protein in malignant tumor of the parotid gland

Mei¹,

Yang²,

Suyila³

et al. 2014

Turk J Med Sci

View full text Add to dashboard Cite

Background/aim: To investigate the expression of P53, P63, and P73 proteins in malignant parotid gland tumors and adjacent nonneoplastic tissues and the association between the 3 proteins and their clinical characteristics. Materials and methods:A total of 40 pairs of paraffin-embedded malignant parotid gland tumors and adjacent nonneoplastic tissues were collected. We detected P53, P63, and P73 protein expression by immunohistochemistry. Statistical analysis was performed by using the chi-square test.Results: P53, P63, and P73 protein expression in malignant parotid gland tumors was higher than their expression in adjacent nonneoplastic tissue (P = 0.030, 0.001, and 0.001, respectively). Expression of P53, P63, and P73 proteins was not associated with age, sex, or lymph node metastasis (P > 0.05). Expression of P53 and P73 proteins, instead of the P63 protein, was correlated to the degree of malignancy (P = 0.026 and 0.018, respectively). There was no significant difference among the P53, P73, and P63 proteins in malignant parotid gland tumors (P > 0.05). In the follow-up, only one patient died of colon cancer. Conclusion:Our results suggest that the P53, P63, and P73 proteins may play a role in the development of malignant parotid gland tumors and provide data for their diagnosis.

show abstract

PCNA, Ki-67 and p53 expressions in submandibular salivary gland tumours

Cited by 62 publications

References 24 publications

Expression of Ki67 and CD105 as Proliferation and Angiogenesis Markers in Salivary Gland Tumors

Expression of Ki67 and CD105 as Proliferation and Angiogenesis Markers in Salivary Gland Tumors

Proliferative potential in benign mixed salivary gland tumors, using Ki67 marker in relation to different clinicopathological parameters

Expression and clinical implications of P53, P63, and P73 protein in malignant tumor of the parotid gland

Contact Info

Product

Resources

About