Peculiarities of Dental Microbial Composition in Patients With a Confirmed Sars-Cov-2 Diagnosis

Abstract

To date, there is a limited amount of literature that describes the features of the microbial composition of plaque in patients with a confirmed diagnosis of SARS-CoV-2. Therefore, this topic is relevant today. Thus, the purpose of this study was to study the characteristics of the microbial composition of dental plaque in patients with a laboratory-confirmed diagnosis of SARS-CoV-2 of mild to moderate severity, with the presence of concomitant oral coinfection or its absence.
 Knowledge of the features of the microbial composition of dental plaque in patients with Sars-CoV-2, as well as timely treatment of inflammatory diseases of the oral cavity will constitute an important stage in the algorithm of specialized therapy.
 The work carried out a comprehensive assessment of the features of the microbial composition of dental plaque in patients with a confirmed diagnosis of SARS-CoV-2. The conclusions are based on the results of a clinical study, which compared the characteristics of the microbial composition of dental plaque in 90 patients aged 20 to 65 years with mild to moderate Sars-CoV-2 with oral coinfection and 15 aged 20 to 65 years with mild to moderate Sars-CoV-2 with no coinfection.
 Results. In the course of the study, the following results were obtained. Patients with + coinfection had a severe course of the disease, transfer to the NIVL was more often required; the duration of hospitalization increased; longer treatment and long-term rehabilitation was required, aimed at normalizing indicators and normalizing the microflora. Based on this, it can be assumed that the presence of oral coinfection affects the severity of the condition and the course of Sars-CoV-2. This means that the risk of coinfection, secondary infection should be taken into account.
 And, finally, knowledge of the mechanisms of interaction of viruses, fungi and bacteria gives hope for the creation of drugs that will effectively resist even such combined attacks.
 Conclusions. The available evidence suggests that the oral cavity may be an active focus of infection and an important reservoir of SARS-CoV-2.