Peel bond strength of soft lining materials with antifungal to a denture base acrylic resin

Abstract

The effect of the addition of nystatin, miconazole, ketoconazole, chlorhexidine, and itraconazole into the soft lining materials Softone and Trusoft on their peel bond strength to a denture base acrylic resin was evaluated. Specimens of soft lining materials (n=7) were made without (control) or with the incorporation of antifungals at their minimum inhibitory concentrations to the biofilm of C. albicans and bonded to the acrylic resin. Peel testing was performed after immersion in distilled water at 37ºC for 24 h, 7 and 14 days. Data (MPa) were analyzed by 3-way ANOVA/Tukey-Kramer test (α=0.05) and the failure modes were classified. The addition of nystatin and ketoconazole did not affect the peel bond strength for up to 14 days. Most failures were predominantly cohesive within soft lining materials. With the exception of itraconazole, incorporating the antifungals into the soft lining materials did not result in values below those recommended for peel bond strength after 7 and 14 days of analysis.

Peel bond strength and antifungal activity of two soft denture lining materials incorporated with 1% chlorhexidine diacetate

“…Thus, all these mechanisms may have resulted in hardness increase of the soft lining materials with the 1.0% CHX addition, which leads to a decrease in their peel bond strength to the denture base resin. These findings corroborate with those of a recent study that demonstrated lower peel bond strength values for the Trusoft material after both the addition of CHX and itraconazole, regardless of the immersion time in distilled water 46) . Bertolini et al 18) suggest that the CHX incorporation did not lead to a clinically relevant change on the material.…”

“…The pattern of CHX incorporation in the polymer results in fragility of the matrix and increases the porosity of the modified materials 44) . This porosity contribute to the CHX releasing, which is also favored by the higher solubility of its molecules in water (0.019 g/ mL) 46) . The addition of a substance such as a drug in a soft material might impair the plasticizers to penetrate in the polymeric chains and form a softened gel.…”

“…In fact, the influence of immersion time on the peel bond strength is a very important factor. Sánchez-Aliaga et al 46) evaluated the peel bond strength after immersion in distilled water for 24 h, 7 and 14 days. The results indicated that the values of peel bond strength significantly increased over time for the materials evaluated 46) , which could be considered an advantage for the lining because it prevents biofilm formation at the interface with the denture base acrylic resin, allowing better prosthesis hygiene and patient comfort 54) .…”

“…Sánchez-Aliaga et al 46) evaluated the peel bond strength after immersion in distilled water for 24 h, 7 and 14 days. The results indicated that the values of peel bond strength significantly increased over time for the materials evaluated 46) , which could be considered an advantage for the lining because it prevents biofilm formation at the interface with the denture base acrylic resin, allowing better prosthesis hygiene and patient comfort 54) . On the other hand, as previously stated, the increase in peel bond strength may be associated with less softness and viscoelasticity, which reduce the material capacity to absorb impact, impairing its ability to promote the needed comfort to the patient 54) .…”

Sustained drug-delivery system: a promising therapy for denture stomatitis?

“…With the exception of itraconazole, the MICs of drugs incorporated into temporary soft lining materials resulted in minimal changes in their peel bond strength to a denture base resin within 14 days 19 . After 14 days, the MICs of nystatin and ketoconazole in both materials and chlorhexidine in temporary resilient liner did not significantly influence their water sorption 10 .…”